thra
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  • Official Full Name
  • thyroid hormone receptor, alpha
  • Background
  • The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms
  • THRA; thyroid hormone receptor, alpha; ERBA1, THRA1, THRA2, thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v erb a) oncogene homolog) , thyroid hormone receptor, alpha (erythroblastic leukemia viral (v erb a) oncogene homolog, avian); thyroid hormone receptor alpha; AR7; EAR 7.1/EAR 7.2; ERBA; NR1A1; THRA3; c erbA 1; C erbA alpha; EAR7; ERBA1; Thyroid hormone receptor alpha 2; TR alpha 2; EAR-7; c-erbA-alpha; ERBA-related 7; OTTHUMP00000164469; OTTHUMP00000164470; V-erbA-related protein 7; triiodothyronine receptor; nuclear receptor subfamily 1 group A member 1; thyroid normone nuclear receptor alpha variant 1; thyroi; THRA1; THRA2; ERB-T-1; c-ERBA-1
Cat.#:THRA-437HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THRA Protein, His-tagged
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Cat.#:THRA-1198HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human THRA, His-tagged
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Cat.#:THRA-1199HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THRA, GST-tagged
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Cat.#:THRA-31520THTag:His
Source (Host):Species:Human
Product nameRecombinant Human THRA, His-tagged
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Cat.#:THRA-31521THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THRA
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Cat.#:THRA-595HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human THRA Protein, DDK-tagged
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Cat.#:THRA-8493HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human THRA, His-tagged
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Cat.#:THRA-16756MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse THRA Protein
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Cat.#:THRA-6058RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat THRA Protein
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Cat.#:THRA-6865CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken THRA
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Cat.#:THRA-1090HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human THRA 293 Cell Lysate
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Involved Pathway

THRA involved in several pathways and played different roles in them. We selected most pathways THRA participated on our site, such as Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with THRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
GHR; TAAR12H; TAAR64; OPRL1; ADRB2A; P2RY2; MTNR1BB; DRD4B; TAAR7A; OPRD1A
Thyroid hormone signaling pathway
PLCE1; NOTCH3; THRA; MED12L; PLCB4; CASP9; MTOR; PRKACB; MED12; PDPK1

Protein Function

THRA has several biochemical functions, for example, TBP-class protein binding, chromatin DNA binding, intronic transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THRA itself. We selected most functions THRA had, and list some proteins which have the same functions with THRA. You can find most of the proteins on our site.
Function
Related Protein
Function TBP-class protein binding
Related Protein PSMC1A; PSMC5; TAF1B; BRF1; PSMC6; TAF1L; EFCAB11; PSMC2; TAF1; GTF2A2
Function chromatin DNA binding
Related Protein NEUROG3; MYOD1; FOXO3; RXRA; RARA; PRDM14; H1F0; RUVBL2; HIST1H1A; RELA
Function intronic transcription regulatory region DNA binding
Related Protein THRA; NKX2-1
Function protein binding
Related Protein TUB; ZFYVE9; CARD11; CDK2AP1; ZBTB49; RASGRP3; MAT2B; EIF1AX; CCDC70; MCCC2
Function protein complex binding
Related Protein TXN2; C8G; DISC1; RARB; NASP; PDX1; BAG3; IGBP1; LEPRE1; TWF1
Function protein domain specific binding
Related Protein FOXA3; CBX3; NR0B1; ICA1; TWIST2; PRKAR2B; GABRR2; HSPA5; FAF1; GSN
Function protein heterodimerization activity
Related Protein TAF8; HIST1H2BD; CREB3L3; HIST1H2AG; TYRO3; ATF6; BDKRB2; NKX2-5; EXT2; Itgam&Itgb2
Function protein homodimerization activity
Related Protein HLA-G; ASNS; SPPL2B; NR2C1; DPY30; USF2; P2RX4; PSPH; DNTTIP1; ADRB2
Function sequence-specific DNA binding
Related Protein FOXO6; ZNF238; ZNF213; ZFP13; PGBD1; PBX4; SOX7; AHR2; TCF7L1A; RORAA
Function steroid hormone receptor activity
Related Protein GPR30; NR1D1; ESRRGB; RXRG; NR2F6; OLFR78; PPARAA; NR2F1B; RORC; NR4A2B
Function steroid receptor RNA activator RNA binding
Related Protein THRA
Function thyroid hormone binding
Related Protein CTSH; THRA; THRB; ALDH1A3; CRYM
Function thyroid hormone receptor activity
Related Protein NR1D2A; NR2F6; NR1D4A; NR4A3; NR1D4B; BRD8; THRAA; NR1I3; THRB; NR1H4
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein FOXF2A; GATA6; THRA; JUN; PDX1; NR1H4; MYOG; FOXC2; HIF1A; MYF6
Function transcription factor activity, sequence-specific DNA binding
Related Protein PBX2; TCF3A; HOXB2A; POU5F1; HOXB8; TFCP2L1; FOXJ1A; ZNF167; CITED2; TCEAL1
Function transcription factor binding
Related Protein MYBBP1A; PAX6; TFDP2; FOXA2; SMARCA4; RB1; PIAS1; NFYC; MYOCD; JUNBB
Function transcription regulatory region DNA binding
Related Protein CALCOCO1; LEF1; MEF2C; SMARCA2; TBP; NR1D1; ARRB1; KLF15; ZNF174; TFAP4
Function zinc ion binding
Related Protein EDEM3; RBM20; RC3H1; PDZRN3; SYTL4; ZCWPW1; TAF2; TRIM45; MATR3L; BLVRA

Interacting Protein

THRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THRA here. Most of them are supplied by our site. Hope this information will be useful for your research of THRA.
MED1; L3MBTL3; AMOTL2; Ncoa6; PKM; UBA1; UBE2N; AKAP13; UBE2V1; TXNRD1; CLIC1