TIAM2 Protein, T-cell lymphoma invasion and metastasis 2


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Official Full Name T-cell lymphoma invasion and metastasis 2
Background This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms TIAM2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; STEF; FLJ41865; SIF and TIAM1 like exchange factor; SIF and TIAM1-like exchange factor; T cell lymphoma invasion and metastasis 2; T lymphoma invasion and metastasis inducing protein 2; TIAM 2; TIAM-2; TIAM2_HUMAN; OTTHUMP00000017472; OTTHUMP00000231963; OTTHUMP00000231964; OTTHUMP00000231965; OTTHUMP00000231968; OTTHUMP00000238735; OTTHUMP00000238736
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TIAM2-1048H Recombinant Human TIAM2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TIAM2-1780HCL Recombinant Human TIAM2 cell lysate N/A
    Human TIAM2-30624TH Recombinant Human TIAM2, His-tagged E.coli His
    Mouse TIAM2-16771M Recombinant Mouse TIAM2 Protein Mammalian Cell His
    Chicken TIAM2-4637C Recombinant Chicken TIAM2 Mammalian Cell His

    TIAM2 involved in several pathways and played different roles in them. We selected most pathways TIAM2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, Fatty acid, triacylglycerol, and ketone body metabolism, G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell death signalling via NRAGE, NRIF and NADE KALRN; ARHGEF17; ITSN1; PLEKHG2; ARHGEF18; CASP2; FGD2; AKAP13; DCLRE1B; ARHGEF1A
    Fatty acid, triacylglycerol, and ketone body metabolism CYP7A1; MED21; MED26; ACOT6; DGAT1B; MED8; APOA5; MED25; THEM5; ACOT9
    G alpha (12/13) signalling events GNA13B; AKAP13; ARHGEF1A; DCLRE1B; OBSCN; ARHGEF18A; ARHGAP4A; ITSN1; RHOB; PLEKHG2
    GPCR downstream signaling RASGRP2; AGTR2; LPAR2A; SSTR3; CHRM1; OBSCN; DGKQ; CCR6; ADCYAP1R1; CCL19A.2
    Metabolism of lipids and lipoproteins AWAT2; DGAT1B; ARSJ; MED31; NFYAL; CPT2; ACAD11; SLC27A2; PIK3R6; SLC44A5B
    NRAGE signals death through JNK AKAP13; ARHGEF18; ABR; FGD4; ARHGEF3; PLEKHG2; FGD4A; FGD2; AATF; TIAM2
    PPARA activates gene expression MED31; MED15; CTGF; MED19; MED8; MED21; G0S2; MED26; MED18; APOA5

    TIAM2 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIAM2 itself. We selected most functions TIAM2 had, and list some proteins which have the same functions with TIAM2. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity RGS10; CDC42EP5; ARHGDIB; CDC42EP4; ASAP2B; ARHGAP18; RACGAP1; STARD8; RAB3GAP1; SMAP1
    Rho guanyl-nucleotide exchange factor activity VAV2; PLEKHG6; RASGRF2; ECT2; PLEKHG2; FARP1; FARP2; C9orf100; PREX1; TRIO
    guanyl-nucleotide exchange factor activity RALGDS; ARHGEF7; SH2D3CB; TIAM2; GDPGP1; VAV3B; ITSN2A; RAPGEFL1; SPATA13; RASGEF1BB
    receptor signaling protein activity ADRB1; KLK1B3; PDCL; IFITM1; GNAZ; PLCG1; KLK1B4; BAG1; BAG4; IL4R

    TIAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIAM2.

    TK1; H2AFX; ANXA7; DNM2; UFD1L; SH3GL2

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