TIAM2
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Official Full Name
T-cell lymphoma invasion and metastasis 2
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Overview
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
TIAM2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; STEF; FLJ41865; SIF and TIAM1 like exchange factor; SIF and TIAM1-like exchange factor; T cell lymphoma invasion and metastasis 2; T lymphoma invasion and metastasis inducing protein 2; TIAM 2; TIAM-2; TIAM2_HUMAN; OTTHUMP00000017472; OTTHUMP00000231963; OTTHUMP00000231964; OTTHUMP00000231965; OTTHUMP00000231968; OTTHUMP00000238735; OTTHUMP00000238736;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TIAM2-30624TH | Recombinant Human TIAM2, His-tagged | E.coli | His |
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| Human | TIAM2-1780HCL | Recombinant Human TIAM2 cell lysate | N/A |
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| Human | TIAM2-1048H | Recombinant Human TIAM2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | TIAM2-517H | Recombinant Human TIAM2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | TIAM2-16771M | Recombinant Mouse TIAM2 Protein | Mammalian Cell | His |
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| Mouse | Tiam2-6425M | Recombinant Mouse Tiam2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | TIAM2-9206M | Recombinant Mouse TIAM2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | TIAM2-9206M-B | Recombinant Mouse TIAM2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | TIAM2-4637C | Recombinant Chicken TIAM2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
TIAM2 involved in several pathways and played different roles in them. We selected most pathways TIAM2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, Fatty acid, triacylglycerol, and ketone body metabolism, G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | AKAP13;NET1;ARHGEF3;BCL2L11;FGD2;OBSCN;MCF2L;ARHGEF1A;AATF |
| Fatty acid, triacylglycerol, and ketone body metabolism | AGPAT2;ACOT12;ACOT11A;AGT;APOA5;ACOT11;MED21;MED7;G0S2 |
| G alpha (12/13) signalling events | ARHGEF9;ECT2;RHOC;ARHGAP4A;ARHGEF1A;KALRN;FGD4A;KALRNB;ARHGEF18 |
| GPCR downstream signaling | OR52B4;GRP;TAC1;CNR2;EDNRAB;PENKB;FGD2;RXFP2B;ABHD6B |
| Metabolism | AKR1C2;SLC35B3;ARSJ;RHAG;PPM1LA;ELA2;CYP2W1;TMEM195;ACOT11A |
| Metabolism of lipids and lipoproteins | YY2;TPTE;MTF1;ESRRA;AWAT1;NFYBA;PMVK;CPT2;ACSF3 |
| NRAGE signals death through JNK | ARHGEF3;FGD4A;ARHGEF9;FGD4;AKAP13;TIAM2;ARHGAP4A;AATF;FGD2 |
| PPARA activates gene expression | MED16;TIAM2;MED22;MED15;MED18;G0S2;SREBF2;MED10;GRHL1 |
TIAM2 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIAM2 itself. We selected most functions TIAM2 had, and list some proteins which have the same functions with TIAM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | CDC42EP5;TBC1D21;RGS2;RGS5A;CHML;DEPDC1A;AGFG2;ACAP2;ARAP2 |
| Rho guanyl-nucleotide exchange factor activity | QUO;ITSN2;FLJ20184;ARHGEF10L;ARHGEF39;FARP1;C3A.1;ARHGEF18;ARHGEF18A |
| guanyl-nucleotide exchange factor activity | FGD3;P2RY12;FGD4;FARP2;RAPGEF4;DIS3;RASGEF1C;PLCE1;ARHGEF7B |
| receptor signaling protein activity | KLK1B4;ADRB1;RGS12;DOK2;ARAF;DOK5;DOK4;IFITM1;NSMAF |
TIAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIAM2.
TK1; H2AFX; ANXA7; DNM2; UFD1L; SH3GL2
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