TLE2 Protein, transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)

TLE2

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TLE2

Official Full Name transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Background Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.
Synonyms TLE2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin like enhancer of split 2, homolog of Drosophila E(sp1); transducin-like enhancer protein 2; enhancer of split groucho 2; ESG; ESG2; FLJ41188; GRG2; Enhancer of split groucho-like protein 2; Groucho2; KIAA4188; MGC124808; mKIAA4188; Tle2 protein; TLE2_HUMAN; transducin like enhancer of split 2; Transducin like enhancer protein 2; Transducin-like enhancer of split 2, homolog of Drosophila E(spl); transducin-like enhancer of split 2, homolog of Drosophila E(sp1)
    • Species :
    • Human
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TLE2-1050HCL Recombinant Human TLE2 293 Cell Lysate HEK293 N/A
    Zebrafish TLE2-7087Z Recombinant Zebrafish TLE2 Mammalian Cell His

    TLE2 involved in several pathways and played different roles in them. We selected most pathways TLE2 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deactivation of the beta-catenin transactivating complex CBY1; SOX9A; SRY; PYGO1; ASH2L; C; CTBP1; SOX9B; SOX32; TLE2
    Degradation of beta-catenin by the destruction complex TLE2; TLE3; AES; TLE3B; FAM123B; CTBP2; TLE1; TLE4; CTBP1
    Formation of the beta-catenin:TCF transactivating complex PYGO2; H3F3B.1; H3F3D; TLE3B; TLE1; SMARCA4; RBBP5; BCL9; CDC73; TLE2
    NOTCH1 Intracellular Domain Regulates Transcription HEY1; TLE4; HEYL; TLE1; HEY2; TLE3; TLE2; TUBB3
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription CDX1; CYR61; SALL4; BCL9; CBY1; TLE1; KCNIP4; AES; T; MYOG
    Repression of WNT target genes TLE3; TLE4; TLE3B; TLE2; AES
    Signal Transduction PTHRP2; APOC2; MKL1B; QRFP; USP34; STRA6; GPRC6A; CRHB; DTX2; PROK2
    Signaling by NOTCH DLK1; RAB6A; MDKB; TLE3; TLE4; DNER; TLE2; DTX2; MDKA; MDK

    TLE2 has several biochemical functions, for example, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE2 itself. We selected most functions TLE2 had, and list some proteins which have the same functions with TLE2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RPRD1A; BTG1; PYROXD1; ANXA7; SMNDC1; TA; SLA2; SRPX2; CHN2; LRP12
    transcription corepressor activity NR2F2; CSDA; TGIF1; E2F7; ALX1; SUFU; DDX54; NFIL3; PPP1R13L; TAF9B

    TLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE2.

    DDB1; NUDC; CUL4B

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