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TLE3

  • Official Full Name

    transducin-like enhancer of split 3, homolog of Drosophila E(spl)

  • Synonyms

    ESG; Grg3a; Grg3b; mKIAA1547; 2610103N05Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Sf9 Insect Cell
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLE3-091H Recombinant Human TLE3 Protein, DDK-tagged Sf9 Insect Cell DDK
Human TLE3-486H Recombinant Human TLE3 protein, GST-tagged E.coli GST Ser484-Tyr772
Human TLE3-1784HCL Recombinant Human TLE3 cell lysate N/A
Mouse TLE3-16814M Recombinant Mouse TLE3 Protein Mammalian Cell His
Mouse TLE3-9232M Recombinant Mouse TLE3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TLE3-9232M-B Recombinant Mouse TLE3 Protein Pre-coupled Magnetic Beads HEK293
Rat TLE3-6083R Recombinant Rat TLE3 Protein Mammalian Cell His
Rat TLE3-5740R Recombinant Rat TLE3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TLE3-5740R-B Recombinant Rat TLE3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TLE3 Related Articles
  • TLE3 Related Research Area

TLE3 involved in several pathways and played different roles in them. We selected most pathways TLE3 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Deactivation of the beta-catenin transactivating complexTLE1;SOX4B;SOX4A;C;BCL9;ASH2L;SOX7;SRY;CBY1
Degradation of beta-catenin by the destruction complexAES;TLE2;CTBP1;TLE3;FAM123B;TLE3B;TLE1;CTBP2;TLE4
Formation of the beta-catenin:TCF transactivating complexLEO1;ASH2L;TLE3;BCL9;TLE1;BCL9L;PYGO2;SMARCA4;H3F3B.1
NOTCH1 Intracellular Domain Regulates TranscriptionTLE1;HEY2;HEYL;TUBB3;TLE3;TLE4;HEY1;TLE2
Repression of WNT target genesTLE3B;TLE2;TLE4;TLE3;AES
Signal TransductionSHB;ARHGAP17B;RGS21;EDNRAB;TAS2R13;ANXA1B;NPHP4;ARHGAP29;PTPRU
Signaling by NOTCHTLE3;MDKA;MDKB;TLE4;DLK1;DNER;RAB6A;DTX2;TLE2
Signaling by NOTCH1HEYL;DLK1;DNER;DTX2;TLE3

TLE3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE3 itself. We selected most functions TLE3 had, and list some proteins which have the same functions with TLE3. You can find most of the proteins on our site.

Function Related Protein
protein bindingC1orf65;SPATA13;SRPK1;CCR3;AMOTL2;CACYBP;PIK3CB;STX7;RBM10

TLE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE3.

lnx2b; AES; HDAC1; tcf7l1a; q81qn9_bacan; q81qv1_bacan; ANXA1; CUL4B; NLK

Laing, AF; Lowell, S; et al. Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression. DEVELOPMENTAL BIOLOGY 397:56-66(2015).
Ortega, FJ; Serrano, M; et al. Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPAR gamma gene expression. JOURNAL OF MOLECULAR MEDICINE-JMM 93:83-92(2015).
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