tlk2
Share
  • Official Full Name
  • tousled-like kinase 2
  • Background
  • The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
  • Synonyms
  • TLK2; tousled-like kinase 2; serine/threonine-protein kinase tousled-like 2; MGC44450; PKU ALPHA; serine/threonine kinase; PKU-ALPHA
Cat.#:TLK2-1108HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TLK2 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:TLK2-1362HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLK2, His & GST tagged
+Inquiry
Cat.#:TLK2-270HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLK2, Gly & Pro tagged
+Inquiry
Cat.#:TLK2-30422THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TLK2
+Inquiry
Cat.#:TLK2-3253HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLK2, GST-tagged
+Inquiry
Cat.#:TLK2-446HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tousled-like Kinase 2, GST-tagged, Active
+Inquiry
Cat.#:TLK2-6171ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TLK2
+Inquiry
Cat.#:TLK2-001HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLK2 cell lysate
+Inquiry
Cat.#:TLK2-554HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLK2 cell lysate
+Inquiry

Involved Pathway

TLK2 involved in several pathways and played different roles in them. We selected most pathways TLK2 participated on our site, such as DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA damage response
CDK5; RAD17; CHEK2; TLK2; GADD45G; RAD9A; RAD1; DDB2; HUS1B; GADD45A

Protein Function

TLK2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLK2 itself. We selected most functions TLK2 had, and list some proteins which have the same functions with TLK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CSNK1D; MYH9; CAMK2D1; KIF6; PRKCA; SKIV2L; YRK; PRKD2; KIT; ABCB3L1
Function protein binding
Related Protein SCOC; MYL12A; AREG; BLOC1S2; PIH1D2; WBP1; CASP1; CENPP; HEXIM1; PPIE
Function protein serine/threonine kinase activity
Related Protein SGK3; MAPK12; ULK2; GRK7B; TAOK3; MTOR; PASK; MAPK8B; EIF2AK4; MAP4K4

Interacting Protein

TLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLK2.
IRF4; IRF7; ASF1B; RPS6KA1

TLK2 Related Articles

Garrote, AM; Redondo, P; et al. Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 70:354-357(2014).
Shanmugam, PST; Dayton, RD; et al. Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-Induced Xerostomia. HUMAN GENE THERAPY 24:604-612(2013).