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TLR8

  • Official Full Name

    toll-like receptor 8

  • Overview

    Toll like receptor 8 (TLR8) family in mammals is comprised of a family of transmembrane proteins which contain multiple leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domains. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa.
  • Synonyms

    TLR8; toll-like receptor 8; CD288; MGC119599; MGC119600;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR8-930H Recombinant Human TLR8 protein, His-tagged Yeast His
Human TLR8-902H Recombinant Human TLR8 protein, His-tagged E.coli His Leu844~Lys1039
Human TLR8-1489H Recombinant Human TLR8 Protein (Glu27-Ile140), N-His tagged E.coli N-His Glu27-Ile140
Human TLR8-4826H Recombinant Human TLR8 Protein (Met1-Thr827), C-His tagged Mammalian cells C-His Met1-Thr827
Mouse TLR8-16830M Recombinant Mouse TLR8 Protein Mammalian Cell His
Mouse TLR8-9239M-B Recombinant Mouse TLR8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tlr8-6455M Recombinant Mouse Tlr8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TLR8-9239M Recombinant Mouse TLR8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tlr8-2079R Recombinant Rat Tlr8 protein, His & T7-tagged E.coli His/T7 His519~Ser812 (Accession # A5H300)
Rhesus Macaque TLR8-4737R Recombinant Rhesus monkey TLR8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR8-4551R-B Recombinant Rhesus Macaque TLR8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TLR8-4551R Recombinant Rhesus Macaque TLR8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TLR8 Related Research Area

TLR8 involved in several pathways and played different roles in them. We selected most pathways TLR8 participated on our site, such as Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Toll-like receptor signaling pathwayTLR3;NFKBIAA;TLR9;PIK3CG;TLR1LA;TICAM2;IRF5;CD86;IFNA12

TLR8 has several biochemical functions, for example, DNA binding, double-stranded RNA binding, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR8 itself. We selected most functions TLR8 had, and list some proteins which have the same functions with TLR8. You can find most of the proteins on our site.

Function Related Protein
DNA bindingBLM;NFE2L1B;HLFA;ZNF643;ORC3;ZNF143;ZNF8;NKX2.4B;PREB
double-stranded RNA bindingHSPD1;STAU1;OAS1;DGCR8;OAS1A;AGO3;STRBP;DROSHA;DHX30
drug bindingP2RX2;DCK;FASN;SRP54A;CHRM2;DHODH;UGT1A7;TLR8;SRP54
single-stranded RNA bindingZFP36;HNRNPA1;HNRNPF;LONP1;DDX58;HMGB1;EIF2C3;TLR7;PIWIL1

TLR8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR8.

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