Recombinant Mouse Tlr8 Protein, Myc/DDK-tagged

• Cat.No.: Tlr8-6455M
• Product Overview: Purified recombinant protein of mouse full-length toll-like receptor 8 (Tlr8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 119.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tlr8 toll-like receptor 8 [ Mus musculus (house mouse) ]
• Official Symbol: Tlr8
• Synonyms: TLR8; toll-like receptor 8
• Gene ID: 170744
• mRNA Refseq: NM_133212
• Protein Refseq: NP_573475
• UniProt ID: P58682