|Official Full Name||T-cell leukemia homeobox 3|
|Background||RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors.;Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved;homeodomain (Dear et al., 1993 (PubMed 8099440)).|
|Synonyms||TLX3; T-cell leukemia homeobox 3; homeo box 11 like 2 , HOX11L2, T cell leukemia, homeobox 3; T-cell leukemia homeobox protein 3; RNX; homeo box 11-like 2; homeobox protein Hox-11L2; T-cell leukemia, homeobox 3; HOX11L2; MGC29804|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TLX3 involved in several pathways and played different roles in them. We selected most pathways TLX3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Transcriptional misregulation in cancer||LYL1; SPI1; PBX3; CCNT1; JMJD1C; ETV4; RUNX2; HOXA9; NR4A3; ZBTB16|
TLX3 has several biochemical functions, for example, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLX3 itself. We selected most functions TLX3 had, and list some proteins which have the same functions with TLX3. You can find most of the proteins on our site.
|protein binding||GDAP2; IFIT1; PFKL; CRHR2; STAR; ADRA2C; TBL1XR1; FBF1; GLIS2; TRMT1|
|sequence-specific DNA binding||MAF; HOXC13A; SOX17; MAFBA; TLX2; GATA4; FOXO1B; FEV; ENG2B; DLX4B|
TLX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLX3.
Ets1; ETS1; LMO2; tcr-alpha_enhancer