tmem67
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  • Official Full Name
  • transmembrane protein 67
  • Background
  • The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6).
  • Synonyms
  • TMEM67; transmembrane protein 67; Meckel syndrome, type 3 , MKS3; Meckelin; JBTS6; MGC26979; NPHP11; meckel syndrome type 3 protein; MKS3; TNEM67
Cat.#:TMEM67-3297HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TMEM67, His-tagged
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Involved Pathway

TMEM67 involved in several pathways and played different roles in them. We selected most pathways TMEM67 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMEM67 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Anchoring of the basal body to the plasma membrane
CENPJ; DYNC1H1; PLK4; FBF1; ODF2B; FGFR1OP; CKAP5; NPHP1; CEP57; CCDC41
Assembly of the primary cilium
DCTN1A; BBS7; CCT5; TTC26; TMEM216; TCTN3; SCLT1; NPHP3; DYNLRB2; CSNK1E
Organelle biogenesis and maintenance
IFT172; IFT-20; CC2D2A; RPGRIP1L; BBS5; IFT122; MRPL51; MRPL40; NPHP1; BBS10

Protein Function

TMEM67 has several biochemical functions, for example, filamin binding, protein binding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMEM67 itself. We selected most functions TMEM67 had, and list some proteins which have the same functions with TMEM67. You can find most of the proteins on our site.
Function
Related Protein
Function filamin binding
Related Protein ZNF664-FAM101A; TMEM67; PDLIM2; FAM101B; MICALL2; HSPB7; FAM101A; NEBL; FBLIM1
Function protein binding
Related Protein TAF7L; HSCB; CRK; IL7R; Ntng2; GHITM; SCYL3; CASC3; NFKBIE; RSU1
Function unfolded protein binding
Related Protein HSP104; TRAP1; SRSF10; DNAJB2; TAPBP; DNAJA2; TBCA; DNAJB1B; NAP1L4; CCT3

TMEM67 Related Articles

Granato, A; Giantin, M; et al. DNA and RNA isolation from canine oncologic formalin-fixed, paraffin-embedded tissues for downstream "-omic" analyses possible or not?. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION 26:117-124(2014).
Ao, M; Sarathy, J; et al. Chenodeoxycholic acid stimulates Cl- secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 305:C447-C456(2013).