tns1
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  • Official Full Name
  • tensin 1
  • Background
  • The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.
  • Synonyms
  • TNS1; tensin 1; matrix remodelling associated 6 , MXRA6, tensin , TNS; tensin-1; DKFZp586K0617; DKFZP434G162; FLJ10923; MGC88584; PRO0929; Tensin; TNS; OTTHUMP00000164058; OTTHUMP00000207627; OTTHUMP00000207628; matrix-remodelling associated 6; Matrix-remodelling-associated protein 6; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127
Cat.#:TNS1-8082HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNS1 protein, His & T7-tagged
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Cat.#:TNS1-7005CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNS1
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Cat.#:TNS1-1804HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TNS1 cell lysate
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Involved Pathway

TNS1 involved in several pathways and played different roles in them. We selected most pathways TNS1 participated on our site, such as Integrin-mediated cell adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Integrin-mediated cell adhesion
TNS1; CAPN3; SEPP1; SEPP1A; CAPN3A; MAPK6; CAPN9; CAPN11; CAPN10; CAPN5

Protein Function

TNS1 has several biochemical functions, for example, actin binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNS1 itself. We selected most functions TNS1 had, and list some proteins which have the same functions with TNS1. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein PHACTR3A; PARVA; EMD; VASPA; SPIRE1; VASP; KLHL1; MYO7B; RP2; HDAC6
Function poly(A) RNA binding
Related Protein YARS2; NOVA1; CSDE1; PPAN; GNB2L1; PARN; SURF6; LGALS1; ACAA2; SRP54B
Function protein binding
Related Protein APOH; CPEB3; NDFIP2; LPA; TGM1; SERPINA5; CD97; NSMCE2; HS3ST5; CUL2

Interacting Protein

TNS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNS1.
MET; AR; KIT; CAPN2; GAB1; PPP1CC; KLF10; WNK1; OSGEP

TNS1 Related Articles

Collaud, S; Tischler, V; et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC CANCER 15:-(2015).
Misra, S; Mukherjee, A; et al. Phosphorylation of PTEN at STT motif is associated with DNA damage response. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 770:112-119(2014).