top3b
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  • Official Full Name
  • topoisomerase (DNA) III beta
  • Background
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.
  • Synonyms
  • TOP3B; topoisomerase (DNA) III beta; DNA topoisomerase 3-beta-1; DNA topoisomerase 3 beta 1; DNA topoisomerase III beta 1; FLJ39376; TOP 3B; TOP3B1; Topo III beta; Topoisomerase DNA III beta; Topoisomerase III beta; OTTHUMP00000198579; OTTHUMP00000198581; DNA topoisomerase III beta-1
Cat.#:TOP3B-3353HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TOP3B, GST-tagged
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Cat.#:TOP3B-8247HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TOP3B protein, His & T7-tagged
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Cat.#:TOP3B-4901RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TOP3B Protein, His-tagged
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Cat.#:TOP3B-1330CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TOP3B
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Cat.#:TOP3B-1810HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TOP3B cell lysate
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Involved Pathway

TOP3B involved in several pathways and played different roles in them. We selected most pathways TOP3B participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Homologous recombination
SYCP3; EME1; XRCC3; RAD51B; RAD51D; RAD51; RAD51L1; POLD2; RPA3; MUS81
Fanconi anemia pathway
USP36; TOP3B; TOP3A; CDK5R2; STRA13; RAD51C; REV3L; FANCC; TELO2; POLI

Protein Function

TOP3B has several biochemical functions, for example, DNA binding, DNA topoisomerase activity, DNA topoisomerase type I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP3B itself. We selected most functions TOP3B had, and list some proteins which have the same functions with TOP3B. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HIF3A; PRDM12; STAT1A; ZNF254; IRX4B; BARX2; PHTF1; LHFP; SP140; NFYAL
Function DNA topoisomerase activity
Related Protein CDK5R2; TOP3B
Function DNA topoisomerase type I activity
Related Protein TOP3B; TOP3A; TOP1L; TOP1; CDK5R2; TOP1MT
Function poly(A) RNA binding
Related Protein NGRN; RP9; EBNA1BP2; IGF2BP3; CSNK1E; NOL7; CHST13; C9orf114; RPL35A; G3BP2
Function protein binding
Related Protein PLG; TCTEX1D1; GAGE5; FKBP1B; ROS1; FBF1; PLXNB2; DNAJB11; RIC8; CAB39

Interacting Protein

TOP3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP3B here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP3B.
ADAMTSL4; SPRED2; TRIM41; MID2; PNMA2; SSX2IP; AARSD1; KRTAP4-12