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TPM4

  • Official Full Name

    tropomyosin 4

  • Overview

    This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TPM4; tropomyosin 4; tropomyosin alpha-4 chain; TM30p1; tropomyosin-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TPM4-3371H Recombinant Human TPM4, GST-tagged E.coli GST 1-248aa
Human TPM4-373H Recombinant Human TPM4, His tagged Human Cell His
Human TPM4-6899H Recombinant Human Tropomyosin 4, His-tagged E.coli His 1-248aa
Human TPM4-3003H Recombinant Human Tropomyosin 4, His-tagged E.coli His
Human TPM4-1036HCL Recombinant Human TPM4 cell lysate Human Cell N/A
Human TPM4-4820H Recombinant Human TPM4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPM4-2424H Recombinant Human TPM4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TPM4-3386H Recombinant Human TPM4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse TPM4-17259M Recombinant Mouse TPM4 Protein Mammalian Cell His
Mouse Tpm4-6601M Recombinant Mouse Tpm4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TPM4-9539M Recombinant Mouse TPM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TPM4-9539M-B Recombinant Mouse TPM4 Protein Pre-coupled Magnetic Beads HEK293
Rat TPM4-6244R Recombinant Rat TPM4 Protein Mammalian Cell His
Rat TPM4-5901R-B Recombinant Rat TPM4 Protein Pre-coupled Magnetic Beads HEK293
Rat TPM4-5901R Recombinant Rat TPM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TPM4 involved in several pathways and played different roles in them. We selected most pathways TPM4 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with TPM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cardiac muscle contractionUQCRC2A;ATP1B3;ATP1B4;UQCRC2B;VMHC;UQCR11;COX7A2L;CACNB4A;COX5B
Adrenergic signaling in cardiomyocytesADRB3B;ADCY1A;ATF6B;ADRB2B;ADCY9;NETO2;CACNB2;Adcy4;KCNQ1
Hypertrophic cardiomyopathy (HCM)SGCD;ITGB6;ITGAV;TPM4;TPM2;CACNB1;ITGA3;DAG1;TNF
Dilated cardiomyopathyPRKACB;MYH7;TNNI3;CACNB2;CACNB3;CACNA2D1;ITGB1;MYBPC3;ITGA7

TPM4 has several biochemical functions, for example, actin binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPM4 itself. We selected most functions TPM4 had, and list some proteins which have the same functions with TPM4. You can find most of the proteins on our site.

Function Related Protein
actin bindingACTN4;MYO9B;EZRB;MYHZ1.2;LMOD1;MYBPC2;WASF3;ARPC5L;SVILA
calcium ion bindingRHOT1;ASPN;PCDH2AA1;PROZ;ANXA6;MYL9B;ENPP2;CAPN3A;AIF1L
protein bindingEIF4H;ZCCHC7;LNPEP;ITGA5;AGGF1;UBA2;KIAA1191;MSH2;TRAF2
structural constituent of muscleMYL2;TPM2;MYOT;PLEC;MYBPC3;TTN;MYBPC2;CAPN3;JPH1

TPM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPM4.

q99ib8-pro_0000045599; PACSIN1; Mast3; ssrna_ac; SLC33A1; Flot1; ATF2; FLNA; CDK2; AKT1; MYH9; ADD1; PPP1CC; IQGAP1; CAPZA2; ARRB1; Tpm1

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