tpm4
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  • Official Full Name
  • tropomyosin 4
  • Background
  • This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • TPM4; tropomyosin 4; tropomyosin alpha-4 chain; TM30p1; tropomyosin-4
Cat.#:TPM4-2424HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TPM4 Protein, MYC/DDK-tagged
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Cat.#:TPM4-3003HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tropomyosin 4, His-tagged
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Cat.#:TPM4-3371HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TPM4, GST-tagged
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Cat.#:TPM4-373HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TPM4, His tagged
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Cat.#:TPM4-6899HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tropomyosin 4, His-tagged
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Cat.#:TPM4-17259MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TPM4 Protein
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Cat.#:TPM4-6244RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TPM4 Protein
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Cat.#:TPM4-1036HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TPM4 cell lysate
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Involved Pathway

TPM4 involved in several pathways and played different roles in them. We selected most pathways TPM4 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with TPM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cardiac muscle contraction
CACNB2A; CACNG4; CACNG8; TPM4B; TNNT2A; CACNB4; UQCRC2; TMEM8C; SLC9A1; COX7C
Adrenergic signaling in cardiomyocytes
ATP1A2; CACNA1DA; CALM3B; PLCB3; PPP2R5E; ATP1B3; CACNG6; ADRB2A; CACNA2D2; CACNG2A
Hypertrophic cardiomyopathy (HCM)
PRKAA2; TPM1; ITGA7; TGFB2; ITGA1; SGCA; PRKAB1; CACNA2D2; IGF1; ITGB1
Dilated cardiomyopathy
CACNA2D1; LMNA; CACNA2D4; ITGB7; TGFB3; PRKACA; SGCA; DMD; TNNC1; ITGA3

Protein Function

TPM4 has several biochemical functions, for example, actin binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPM4 itself. We selected most functions TPM4 had, and list some proteins which have the same functions with TPM4. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein MYO7A; WASF2; HOMER2; KLHL33; TBC1D21; MSRB1A; BAIAP2L1; TMOD2; MYH13; GAS2L3
Function calcium ion binding
Related Protein CASQ1A; MAN1C1; AIF1; PCDH2AB5; PCDH1G30; PLCB3; TMPRSS6; ELTD1; TNNC1B; PCDH1G9
Function protein binding
Related Protein MAGEA1; HTRA3; KRT79; BOLL; UQCC2; PAQR5; SPHK1; RBM10; FGFRL1A; HGF
Function structural constituent of muscle
Related Protein MYOT; ANKRD2; TTN; TPM1; MYL1; MYL6B; MYL5; DMD; ASPH; PDLIM3

Interacting Protein

TPM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPM4.
q99ib8-pro_0000045599; PACSIN1; Mast3; ssrna_ac; SLC33A1; Flot1; ATF2; FLNA; CDK2; AKT1; MYH9; ADD1; PPP1CC; IQGAP1; CAPZA2; ARRB1; Tpm1