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TRIM23

Official Full Name

tripartite motif containing 23
Overview

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
Synonyms

TRIM23; tripartite motif containing 23; ADP ribosylation factor domain protein 1, 64kDa , ARFD1, tripartite motif containing 23; E3 ubiquitin-protein ligase TRIM23; ARD1; RNF46; ADP ribosylation factor domain protein 1; ARF domain protein 1; ARFD1; GTP binding protein ARD 1; N-acetyltransferase ARD1 human homolog of; N-acetyltransferase homolog of S. cerevisiae ARD1; Tripartite motif protein TRIM23; OTTHUMP00000123452; OTTHUMP00000123453; OTTHUMP00000222562; RING finger protein 46; GTP-binding protein ARD-1; tripartite motif-containing 23; tripartite motif-containing pr;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TRIM23-30124TH	Recombinant Human TRIM23	Wheat Germ	N/A	574 amino acids	Inquiry
Human	TRIM23-3408H	Recombinant Human TRIM23, GST-tagged	E.coli	GST	C-term-300aa	$319 / 25ug
Human	TRIM23-1824HCL	Recombinant Human TRIM23 cell lysate		N/A		Inquiry
Human	TRIM23-538HF	Recombinant Full Length Human TRIM23 Protein	In Vitro Cell Free System		574 amino acids	Inquiry
Mouse	TRIM23-17348M	Recombinant Mouse TRIM23 Protein	Mammalian Cell	His		Inquiry
Mouse	TRIM23-9595M-B	Recombinant Mouse TRIM23 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	TRIM23-9595M	Recombinant Mouse TRIM23 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TRIM23-6273R	Recombinant Rat TRIM23 Protein	Mammalian Cell	His		Inquiry
Rat	TRIM23-5930R-B	Recombinant Rat TRIM23 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	TRIM23-5930R	Recombinant Rat TRIM23 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TRIM23-4956R	Recombinant Rhesus monkey TRIM23 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TRIM23-4770R	Recombinant Rhesus Macaque TRIM23 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TRIM23-4770R-B	Recombinant Rhesus Macaque TRIM23 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TRIM23-4530Z	Recombinant Zebrafish TRIM23	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TRIM23 Related Articles

TRIM23 involved in several pathways and played different roles in them. We selected most pathways TRIM23 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TRIM23 has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM23 itself. We selected most functions TRIM23 had, and list some proteins which have the same functions with TRIM23. You can find most of the proteins on our site.

Function	Related Protein
GDP binding	RAB18;RRAS;RAP2C;GEM;SRP54;RAB28;RAB5C;RAB35;RAN
GTP binding	MFHAS1;RHOD;IRGE4;RAC1B;SEPT2;SEPT7B;OPA1;GTPBP1L;SEPT4
GTPase activity	GNA12A;RND1;RAB40B;RAB11B;TUBG2;RAB3DA;MX2;EEF1A1L2;RAB35
enzyme activator activity	GTF3C4;MMP15;LTC4S;TAB1;PPP1R12B;SFTPB;ARL1;TIMP2;SLX4
identical protein binding	CLDN14;CDC42;AHI1;CLDNG;PRMT1;S100A1;PDCD6;CRYAB;PUF60
ligase activity	TRAF3;RNF144AB;RNF217;CBL;LIPT2;STUB1;TRIM32;UBOX5;HERC5
protein binding	TEX264;GSTM4;RAMP3;STX8;NSMCE2;FAM151B;CCDC64B;RPS10;FRMPD2
ubiquitin-protein transferase activity	HECTD3;UBE2S;FBXO4;ZYG11;UBR5;ZNRF1;ITCH;RFWD3;SKP1
zinc ion binding	RBBP6;PHC1;ZCWPW2;CUL9;ADH8B;RFWD3;PHC2A;ZNRF4;SETDB1B

TRIM23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM23 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM23.

PSMA1; TROAP; BAG1; COX5B

Smith, S; Gabhann, JN; et al. Estrogen Receptor alpha Regulates Tripartite Motif-Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY 66:163-172(2014).

Tateda, K; Okazaki, S; et al. The suppression of TRIM21 and the accumulation of IFN-alpha play crucial roles in the pathogenesis of osteonecrosis of the femoral head. LABORATORY INVESTIGATION 92:1318-1329(2012).