trim23
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  • Official Full Name
  • tripartite motif containing 23
  • Background
  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
  • Synonyms
  • TRIM23; tripartite motif containing 23; ADP ribosylation factor domain protein 1, 64kDa , ARFD1, tripartite motif containing 23; E3 ubiquitin-protein ligase TRIM23; ARD1; RNF46; ADP ribosylation factor domain protein 1; ARF domain protein 1; ARFD1; GTP binding protein ARD 1; N-acetyltransferase ARD1 human homolog of; N-acetyltransferase homolog of S. cerevisiae ARD1; Tripartite motif protein TRIM23; OTTHUMP00000123452; OTTHUMP00000123453; OTTHUMP00000222562; RING finger protein 46; GTP-binding protein ARD-1; tripartite motif-containing 23; tripartite motif-containing pr
Cat.#:TRIM23-30124THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRIM23
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Cat.#:TRIM23-3408HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM23, GST-tagged
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Cat.#:TRIM23-17348MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRIM23 Protein
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Cat.#:TRIM23-6273RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRIM23 Protein
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Cat.#:TRIM23-4956RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRIM23 Protein, His-tagged
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Cat.#:TRIM23-4530ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRIM23
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Cat.#:TRIM23-1824HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TRIM23 cell lysate
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Protein Function

TRIM23 has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM23 itself. We selected most functions TRIM23 had, and list some proteins which have the same functions with TRIM23. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein RAB3B; RAP2C; PRPS1; RAB28; RAB27B; PCK1; EIF2B1; GNAI1; IIGP1; RAB9B
Function GTP binding
Related Protein NKIRAS1; ERAS; RAB13; GTPBP8; IFT27; SRL; TUBB; ATL3; GUCY2C; ARHGAP35
Function GTPase activity
Related Protein GNA15.1; RAN; RAB11B; TUBA8L3; RRAGD; RAB32; RHOU; TUBA2; ARL2; RAB15
Function enzyme activator activity
Related Protein HSPB2; CXCL1; CFLAR; DBF4; DCP1A; GTF3C4; SAE1; SEC14L2; ALDH1A2; CTSA
Function identical protein binding
Related Protein ABCD1; DNM1; THG1L; GCG; GOT2B; DES; IFI203; ACADM; MCPH1; DYNLT1A
Function ligase activity
Related Protein TRIM56; CBLB; UBE2G1B; MUL1; ARIH2; RBX1; UBR7; UBE1Y1; PDZRN3; TRIM24
Function protein binding
Related Protein CDCP1; UBXN4; UBE2L3; FXN; PDCD5; DAZL; CBX3; CDX1; KCNE1; NIPSNAP1
Function ubiquitin-protein transferase activity
Related Protein RBBP6; FBXO3; TRIM21; CDC34; RNF141; RNF139; SMURF2; WWP2; TRIM69; BTR22
Function zinc ion binding
Related Protein RNF170; LIMA1; UNK; ESRRB; LONRF3; PHF20B; SLC30A8; NR2E3; SEC24D; GATAD2B

Interacting Protein

TRIM23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM23 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM23.
PSMA1; TROAP; BAG1; COX5B

TRIM23 Related Articles

Smith, S; Gabhann, JN; et al. Estrogen Receptor alpha Regulates Tripartite Motif-Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY 66:163-172(2014).
Tateda, K; Okazaki, S; et al. The suppression of TRIM21 and the accumulation of IFN-alpha play crucial roles in the pathogenesis of osteonecrosis of the femoral head. LABORATORY INVESTIGATION 92:1318-1329(2012).