| Description : |
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
89.250kDa inclusive of tags |
| Protein Length : |
574 amino acids |
| AA Sequence : |
MATLVVNKLGAGVDSGRQGSRGTAVVKVLECGVCEDVFSL QGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTD LGDSGVWGLKKNFALLELLERLQNGPIGQYGAAEESIGIS GESIIRCDEDEAHLASVYCTVCATHLCSECSQVTHSTKTL AKHRRVPLADKPHEKTMCSQHQVHAIEFVCLEEGCQTSPL MCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTF TEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEHVPGT AENARSCIRAYFYDLHETLCRQEEMALSVVDAHVREKLIW LRQQQEDMTILLSEVSAACLHCEKTLQQDDCRVVLAKQEI TRLLETLQKQQQQFTEVADHIQLDASIPVTFTKDNRVHIG PKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNV ETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVD SSHRDRISEAHSELAKLLTEKELRDALLLIFANKQDVAGA LSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDW LSRQLVAAGVLDVA |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
