trim32
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  • Official Full Name
  • tripartite motif containing 32
  • Background
  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
  • Synonyms
  • TRIM32; tripartite motif containing 32; LGMD2H, limb girdle muscular dystrophy 2H (autosomal recessive) , tripartite motif containing 32; E3 ubiquitin-protein ligase TRIM32; BBS11; HT2A; TATIP; 72 kda Tat interacting Protein; LGMD2H; Limb girdle muscular dystrophy 2H (autosomal recessive); Limb girdle muscular dystrophy 2H; Muscular dystrophy Hutterite type; TAT interactive protein 72KD; Tripartite Motif Containing Protein 32; Zinc Finger Protein HT2A; OTTHUMP00000022763; zinc-finger protein HT2A; 72 kDa Tat-interacting protein; TAT-interactive protein, 72-KD; tripartite motif-containing 32; tripartite motif-containing protein 32
Cat.#:TRIM32-198HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TRIM32, GST-tagged
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Cat.#:TRIM32-4962RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRIM32 Protein, His-tagged
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Cat.#:TRIM32-6330ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRIM32
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Cat.#:TRIM32-782HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TRIM32 293 Cell Lysate
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Involved Pathway

TRIM32 involved in several pathways and played different roles in them. We selected most pathways TRIM32 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM32 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
ITCHA; CUL3A; CDH1-A; TRIP12; PIAS4A; SKP1; UBE2Q2; AIRE; UBE2Q1; UBE2H

Protein Function

TRIM32 has several biochemical functions, for example, RNA binding, Tat protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM32 itself. We selected most functions TRIM32 had, and list some proteins which have the same functions with TRIM32. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein CELF3; RPL24; SARS; FARSB; DDX3X; WT1; HNRNPR; THOC1; EXOSC6; KHDC3
Function Tat protein binding
Related Protein MDFIC; ACTB; SMARCB1; GABARAPL1; TRIM32; SMARCA4; NPM1; DLL1
Function ligase activity
Related Protein PIAS2; UBE4B; TTLL9; RFWD3; RNF212; RBBP6; FANCL; MEX3C; UBR4; TRIM33
Function myosin binding
Related Protein FXYD1; VAMP2; TRIM32; VEZT; KIRREL; DMD; MYBPC3; GIPC1; SLC6A4; USH2A
Function protein binding
Related Protein TBC1D2; CREB3L3; STARD10; AVPI1; ACTB; PPP3R1; PA2G4; DR1; MX1; PSEN1
Function protein self-association
Related Protein ACHE; NKX3; ZFP639; TNFAIP3; ZNF496; ABCD3; TRP53; SHANK3; VAMP2; NKX3-1
Function transcription coactivator activity
Related Protein ECD; PIAS2; RUNX1; RNF20; HCFC2; ELF3; SETD3; YAP1; SMARCE1; MMS19
Function translation initiation factor binding
Related Protein EIF3BA; CELF1; RPS24; POLR2G; POLR2GL; EIF3C; TBL2; ZNF259; EIF3M; EIF3F
Function ubiquitin binding
Related Protein NUP62; TSG101; UBAP1; IWS1; BCL10; UBR5; USP5; CXCR4; CRY1; OTUB2
Function ubiquitin protein ligase activity
Related Protein RNF220; PJA1; HECW1B; UBE2B; G2E3; UBE3C; UBE2U; TRIM72; PDZD4; SIAH2L
Function ubiquitin-protein transferase activity
Related Protein STUB1; RNF5; SMURF1; BTR22; RNF31; FLJ11011L; BIRC5A; UHRF1; ZER1; HECW1B
Function zinc ion binding
Related Protein RNF207; ZDHHC5; ZMAT2; NR6A1B; CXXC1B; PGR; TAF2; PGLYRP5; TRHDE; BMP1B

Interacting Protein

TRIM32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM32 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM32.
PDE9A; SCGB1A1; UBE2U; UBQLN1; b3kpu6_human