trim33
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  • Official Full Name
  • tripartite motif containing 33
  • Background
  • The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TRIM33; tripartite motif containing 33; ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA; E3 ubiquitin-protein ligase TRIM33; TIF1-gamma; protein Rfg7; ectodermin homolog; RET-fused gene 7 protein; tripartite motif-containing 33; transcriptional intermediary factor 1 gamma;
Cat.#:TRIM33-336HTag:Flag
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human TRIM33 Protein, Flag-tagged
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Cat.#:TRIM33-110HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TRIM33 Protein, His-tagged
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Cat.#:TRIM33-227HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM33 Protein, GST-tagged
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Cat.#:TRIM33-228HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM33 Protein, His-tagged
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Cat.#:TRIM33-229HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM33 Protein, GST-tagged
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Cat.#:TRIM33-230HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM33 Protein, His-tagged
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Cat.#:TRIM33-506HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human TRIM33 Protein, DDK-tagged
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Cat.#:TRIM33-83HTag:His|Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM33, His&FLAG-tagged
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Cat.#:TRIM33-859ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRIM33
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Cat.#:TRIM33-781HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TRIM33 293 Cell Lysate
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Involved Pathway

TRIM33 involved in several pathways and played different roles in them. We selected most pathways TRIM33 participated on our site, such as Downregulation of SMAD2/3:SMAD4 transcriptional activity, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD3B; PARP1; RNF111; SKIB; SKI; SKIA; USP9; TRIM33; SKILB; USP9X
Gene Expression
ZNF461; EARS2; ZNF530; ZNF556; SLC38A8; BRF1; ZNF202; MTA2; TET2; ZNF213
Generic Transcription Pathway
ZNF225; ZNF224; FAM36A; ZNF350; MED7; MED26; ZNF496; ZKSCAN3; ZNF548; ZNF285A
Signal Transduction
CCL35.1; RGS14; FMNL2; ABCA4A; SST; SOX4A; MDKA; GPR77; F11R.2; DNER
Signaling by TGF-beta Receptor Complex
NEDD8; UCHL5; NEDD8L; USP9; SKIA; CGNB; USP15; TRIM33; STRAP; SKILB
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
TRIM33; USP9X; SKILB; USP9; SKIB

Protein Function

TRIM33 has several biochemical functions, for example, DNA binding, R-SMAD binding, co-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM33 itself. We selected most functions TRIM33 had, and list some proteins which have the same functions with TRIM33. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SP9; MCMDC2; ZFP36L1; ZNF800; IRX5A; HIST1H101; SCML2; RAG1; ZNF266; RELA
Function R-SMAD binding
Related Protein ANKRD1; AXIN1; ZEB2; PAX6; JUN; RANBP3; SMAD2; FOS; PPM1A; SMAD6
Function co-SMAD binding
Related Protein USP9X; CITED1; SMAD6; FOXH1; SMAD1; SMAD2; SMAD3; TRIM33; GATA4; TGIF1
Function ligase activity
Related Protein SMURF1; RNF213; RFFL; HECTD1; RNF38; ZFP91; GATB; BTR22; TRIM2; TOPORS
Function protein binding
Related Protein CORO1C; PRPF4B; HAND2; TRIM54; DMC1; Pilrb1; SMPD1; CBLL1; CST2; AGPAT4
Function ubiquitin-protein transferase activity
Related Protein TRIP12; G2E3; FBXO25; BRAP; RNF152; TRIM13; FBXL14A; MARCH6; PRP19; BIRC8
Function zinc ion binding
Related Protein LHX8; TRIP6; CRIP3; WT1; PXN; PHF2; ADAM20; KMT2E; MMP3; COP1

Interacting Protein

TRIM33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM33 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM33.
SMAD4; SMAD2; gata1_human_gene; gata2_human_gene; TAL1; CDK9