Recombinant Human TRIM33 Protein, Flag-tagged

• Cat.No.: TRIM33-336H
• Product Overview: Full length Recombinant Human TRIM33 (Tripartite Motif Containing 33) Protein is produced in SF9 Insect Cells and is fused with a Flag tag at the N-terminal.

Specification

• Description: TRIM33 (UniProt/Swiss-Prot entry Q9UPN9) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. TRIM33 is an E3 ubiquitin-protein ligase, which promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. It may act as a transcriptional corepressor and inhibits the transcriptional response to the TGF-beta/BMP signaling cascade. However, molecules that interact with this protein have not yet been identified..TRIM33 also plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Defects in TRIM24 cause thyroid papillary carcinoma.
• Source: Insect Cells
• Species: Human
• Tag: Flag
• Form: 20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
• Purity: Purified using FPLC, >95% purity as determined by SDS-PAGE.
• Notes: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
• Stability: Guaranteed stable for 2 years from date of receipt when stored properly.
• Storage: Store at -80 centigrade.
• Concentration: 0.5 µg/µl

Gene Information

• Gene Name: TRIM33 tripartite motif containing 33 [ Homo sapiens ]
• Official Symbol: TRIM33
• Synonyms: TRIM33; tripartite motif containing 33; FLJ11429; KIAA1113; PTC7; ret fused gene 7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA; ECTO; FLJ32925
• Gene ID: 51592
• mRNA Refseq: NM_015906
• Protein Refseq: NP_056990
• MIM: 605769
• UniProt ID: Q9UPN9