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TRNT1

Official Full Name

tRNA nucleotidyl transferase, CCA-adding, 1
Overview

The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the;3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become aminoacylated;and to participate in protein biosynthesis (Lizano et al., 2007 (PubMed 17204286)).
Synonyms

TRNT1; tRNA nucleotidyl transferase, CCA-adding, 1; CCA tRNA nucleotidyltransferase 1, mitochondrial; CCA1; CGI 47; MtCCA; AA408384; C76540; CCA adding; EC 2.7.7.25; Mitochondrial CCA adding tRNA nucleotidyltransferase; Mitochondrial tRNA nucleotidyl transferase, CCA adding; mt CCA adding enzyme; mt Trat; mt tRNA adenylyltransferase; mt tRNA CCA diphosphorylase; mt tRNA CCA pyrophosphorylase; MTO2; TRMU; tRNA nucleotidyl transferase; tRNA nucleotidyl transferase CCA adding 1; OTTHUMP00000195199; OTTHUMP00000206931; OTTHUMP00000207297; mt CCA-adding enzyme; mt tRNA CCA-diphosphorylase; mt tRNA CCA-pyrophosphorylase; tRNA-nucleotidyltransferase 1, mitochondrial; mitochondrial CCA-adding tRNA-nucleotidyltransferase; mitochondrial tRNA nucleotidyl transferase, CCA-adding; CGI-47;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TRNT1-749HCL	Recombinant Human TRNT1 293 Cell Lysate	HEK293	N/A	Inquiry
Human	TRNT1-2182H	Recombinant Human TRNT1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	TRNT1-17428M	Recombinant Mouse TRNT1 Protein	Mammalian Cell	His	Inquiry
Mouse	Trnt1-6670M	Recombinant Mouse Trnt1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	TRNT1-9645M	Recombinant Mouse TRNT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	TRNT1-9645M-B	Recombinant Mouse TRNT1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	TRNT1-383Z	Recombinant Zebrafish TRNT1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TRNT1 Related Articles

TRNT1 involved in several pathways and played different roles in them. We selected most pathways TRNT1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RNA transport	XPO5;EIF1AXB;NUP205;ALYREF;POM121L2;EIF4A1A;STRAP;NUP160;PABPC3

TRNT1 has several biochemical functions, for example, ATP binding, ATP:3-cytidine-cytidine-tRNA adenylyltransferase activity, CTP:3-cytidine-tRNA cytidylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRNT1 itself. We selected most functions TRNT1 had, and list some proteins which have the same functions with TRNT1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	HSPA4B;CKMT1B;ACACA;P2RX8;UBE2S;DHX36;ATP5B;SGK3;CSF1RA
ATP:3-cytidine-cytidine-tRNA adenylyltransferase activity
CTP:3-cytidine-tRNA cytidylyltransferase activity
CTP:tRNA cytidylyltransferase activity
tRNA adenylyltransferase activity
tRNA binding	PSTK;AARSD1;TERT;DARS2;XPOT;SEPSECS;TRNT1;TRMU;MADD

TRNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRNT1.

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Iolascon, A; et al. Transfer RNA and syndromic sideroblastic anemia. BLOOD 124:2763-2764(2014).

Chakraborty, PK; Schmitz-Abe, K; et al. Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). BLOOD 124:2867-2871(2014).