trp53
Share
  • Official Full Name
  • transformation related protein 53
  • Synonyms
  • bbl; bfy; bhy; p44; p53; Tp53
Cat.#:TRP53-17432MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRP53 Protein
+Inquiry
Cat.#:Trp53-5632MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Trp53 protein, His-tagged
+Inquiry
Cat.#:Kit-2107Tag:N/A
Source (Host):Species:
Product namep53 Transcription Factor Activity Assay Kit
+Inquiry
Cat.#:Kit-0642Tag:N/A
Source (Host):Species:
Product namep53 Translocation Assay Kit (Cell-Based)
+Inquiry

Involved Pathway

Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP4K2; FGF6B; PPM1AB; RAC3A; NFATC3; CACNA1SB; FGFR1; CACNA1H; KRAS; TGFBR1
Sphingolipid signaling pathway
PTEN; PLD2; PPP2R5E; GNAI2; PIK3R5; CERS2; S1PR4; SMPD1; PLD1; TNF
Cell cycle
CKS1B; CEP135; CSNK1D; CTDNEP1; DYNC1H1; CCDC99; SYCE1; NUMA1; SET; SPC25
p signaling pathway
SHISA5; CCNB3; TP53I3; TSC2; PTENA; PIDD1; IGFBP3; CD82B; PPM1DA; PERP
PIK-Akt signaling pathway
NFKB1; IFNA21; Il6ra; PKN1; LAMA1; PIK3R2; FGF21; CASP9; LAMB4; TCL1B
Apoptosis
AKT1; BNIP3LB; CASP12; NFKBIAB; PRKAR2AB; BAXA; BIDA; DFFB; DBNLA; HIST1H1E
Wnt signaling pathway
SFRP1; FZD9B; PRKCG; APC; WNT7AA; PRKACG; CTNNBIP1; RAC1A; FOSL1A; SERPINF1
Neurotrophin signaling pathway
KIDINS220; NFKBIB; CALML5; TP53; NTF3; RAC1; KRAS; MAPK1; SHC2; SH2B1
Thyroid hormone signaling pathway
MED4; RXRB; ATP2A2; TRP53; PIK3R1; ACTG1; RXRA; KAT2B; DIO1; BMP4
Amyotrophic lateral sclerosis (ALS)
TNFRSF1A; TNF; PPP3CA; BAX; CASP9; PPP3R1; PPP3R2; TOMM40L; APAF1; BCL2L1
Huntingtons disease
NDUFA13; NDUFAB1; DCTN2; SIN3A; POLR2A; SDHC; COX8C; SDHA; COX6B1; RCOR1
Hepatitis C
IFNA16; CXCL8; CLDN10; OSTN; IFNA7; NFKB1; AKT1; TRADD; KRAS; CLDN6
Hepatitis B
PRKCB; IFNB1; TIRAP; IFNA17; KRAS; RELA; PTEN; DDX58; MAPK3; FADD
Measles
CD3E; CD3D; RAB9A; IFNA8; IFNA12; IFNA13; TYK2; MX1; IFNB1; CCND3; IL4
HTLV-I infection
IL2RB; ICAM1; ANAPC7; WNT11; WNT10B; FZD8; Fzd4; PIK3R3; FZD9; RELB
Herpes simplex infection
TLR9; NXF1; FADD; SRSF6; NFKBIAA; HLA-DOB; HLA-E; CLOCK; CYCS; C5
Epstein-Barr virus infection
NFKBIA; PSMC5; PIK3R5; PLCG2; PIK3CA; NFKB1; POLR3K; EP300; PSMD6; AKT1
Pathways in cancer
GNG4; CCNE1; BCL2; GRB2; PLD1; MMP9; WNT10B; GNG7; FGF22; CASP9
Transcriptional misregulation in cancer
ELK4; ETV7; PER2; HOXA11; CCNT2; CD86; FLI1; BIRC3; NGFR; ETV6
Viral carcinogenesis
CCNA1; PIK3R2; MRPS18B; DDX3X; CCNE2; HIST1H4E; PRKACA; STAT5A; VAC14; CDK1
Proteoglycans in cancer
STAT3; PDCD4; PLAUR; GPC1; RPS6KB1; VAV2; ERBB3; MAPK13; ESR1; TLR2
MicroRNAs in cancer
SHC4; PDCD4; RDX; TNC; NOTCH2; PIK3CA; PIK3R2; TTC6; FSCN1; RASSF1
Colorectal cancer
RAC1; AXIN1; TGFBR1; CYCS; APPL1; MLH1; TCF7L2; ARAF; MAPK1; TRP53
Pancreatic cancer
TGFB2; TGFB1; BRCA2; RB1; TGFA; PIK3R5; RALBP1; ARAF; ARHGEF6; PIK3CA
Endometrial cancer
BAD; KRAS; GSK3B; BRAF; RAF1; AXIN2; MAPK3; PIK3R2; TRP53; PIK3CB
Glioma
IGF1R; CAMK2A; PRKCB; CALML3; CAMK2B; MTOR; PIK3R2; BRAF; CCND1; CALM2
Prostate cancer
MAP4K1; SPINK1; ARAF; EP300; HSP90AA1; SMARCC2; TRP53; ARID1A; Pdgfa&Pdgfb; CREB5
Thyroid cancer
RXRB; MAPK3; RXRA; NTRK1; NRAS; PPARG; MAP2K2; CCDC6; RXRG; TFG
Basal cell carcinoma
Fzd4; WNT16; AXIN2; WNT9B; DVL1; WNT2B; APC; SUFU; SETD6; WNT1
Melanoma
MDM2; PDGFD; FGF4; PDGFA; FGF17; FGF3; MET; Pdgfa&Pdgfb; FGF13; ARAF
Bladder cancer
CXCL8; TYMP; THBS1; UPK3A; MMP9; MDM2; BRAF; CDKN2A; E2F1; E2F2
Chronic myeloid leukemia
MAP2K2; SHC4; MDM2; PIK3CG; SHC1; PIK3R3; TGFBR2; KRAS; CTBP1; CDK6
Small cell lung cancer
LAMA3; LAMB1; BIRC3; TRAF1; ITGB1; AKT1; RXRA; PIK3CA; APAF1; PIK3R5
Non-small cell lung cancer
RXRB; RAF1; ERBB2; AKT1; PDPK1; FOXO3; MAP2K2; TP53; PIK3CG; PLCG1
Central carbon metabolism in cancer
G6PD; IDH1; G6PDX; PFKL; GLS; HKDC1; SIRT3; SLC16A3; RAF1; MET

Protein Function

Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF20A; CDC34B; PDS5B; MAPK1; KIF18B; DDX19A; ABL1; SMARCA4A; RAF1; AARSD1
Function DNA binding
Related Protein MYSM1; SETDB1; NTNG1; ZNF559; LBX1B; ATXN1L; HER2; ZNF280B; MYCB; ZNF71
Function MDM2/MDM4 family protein binding
Related Protein CAV1; PPARA; RFWD3; PSME3; CDKN2A; TRP53; CDK5RAP3
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein STAT5A; TBR1; ZFP335; TFAP2A; SOX3; WBP2; NLRC5; IRF7; ZNF277; YAP1
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein ZGLP1; GATA4; CREB3L4; RXRG; GATA5; GFI1AA; BARHL2; PRKCBP1L; ZSCAN2; NHLH2
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein SOX30; SOX8B; FOXB1; PHB; SIM1A; ZNF496; PAX6; FOXO3B; JUNBB; ETV3
Function RNA polymerase II transcription factor binding
Related Protein ZFPM1; ZFPM2; ATF4; WWP2; PITX2; CHST13; GATA6; Ar; TRPS1; TOX2
Function chaperone binding
Related Protein INS1; AHSA1; TFRC; DLST; ATP1A2; AMFR; CDC37; GRPEL1; BAG1; CLU
Function chromatin binding
Related Protein CDK9; HIST2H3C1; CREBBP; CCNT1; SMAD6; TOX3; SP140L; CENPA; HMGB3B; CUX1
Function copper ion binding
Related Protein LOXL5A; HAMP; GPC1; TYRP1; CCC2; METTL17; SNAI3; PARK7; ATOX1; LOXL5B
Function core promoter sequence-specific DNA binding
Related Protein NRF1; ZFP750; PDX1; SOX4; ESR2; NR1D1; TRP53; TOP1; NFYA; SIRT1
Function damaged DNA binding
Related Protein OGG1; H2AFX; FANCG; ERCC3; CREBBP; RAD23AB; BRCA1; RAD23B; POLD1; RPA3
Function double-stranded DNA binding
Related Protein HNRPDL; GTF2H4; CRY1; GATA1A; AFF3; KLF6; CGGBP1; TRP53; PYDC3; EGFR
Function enzyme binding
Related Protein PDE4D; TSPAN10; NOTCH3; MTA1; TRP53; NFKBIA; PRKCA; USF1; CBX3; RAD9
Function histone acetyltransferase binding
Related Protein TRP53; FOXP3; TRIM68; SIRT2; MEF2A; ETS1; TRIP4; TAF7L; PAX6; CEBPB
Function histone deacetylase regulator activity
Related Protein TP53; MAPK8; TRP53; NCOR1
Function identical protein binding
Related Protein VWF; SOD1; RELA; PLDN; RCAN1; C1QTNF9; MLL1; CIDEB; DNMT3A; PTK6
Function metal ion binding
Related Protein MLL1; CAR6; GTF3AB; ILKAP; ZBTB7A; MPPED2; CA15C; GTF3AA; AMY1B; ZFP330
Function p53 binding
Related Protein RCHY1; ZFP385C; AAAS; TP53RK; EHMT2; PLK3; RNF34; SETD7; KDM1A; BANP
Function protease binding
Related Protein BDKRB2; TYSND1; F3; SERPINA1D; TIMP2A; SEMG2; SERPINB13; BRCA2; INS2; A2M
Function protein C-terminus binding
Related Protein EFHC1; CACNA1B; SDCBP; AXIN1; YEATS4; BCL10; PICK1; TAF13; MID1IP1; PEX1
Function protein N-terminus binding
Related Protein STX1A; SNF8; RELA; RASSF1; GLRX; PDCD10; ZWINT; KCNIP1; ALOX5AP; EXOC5
Function protein binding
Related Protein SLC4A1AP; BACH1; ZFP488; GSPT2; GHRHR; EFCAB4A; SHC4; FAM103A1; STAP2; RPS6KC1
Function protein heterodimerization activity
Related Protein BCL2L2; KCNK3; HIST1H2A9; HIST1H2BM; WHRN; PPP1CBL; ZHX1; Defa-rs7; HIST1H4B; CXorf15
Function protein kinase binding
Related Protein TRAF2; Fert2; CACNB2; CALM1; MAPK4; SUFU; STAT3; POLA1; FBXW5; ZFP36
Function protein phosphatase 2A binding
Related Protein ENSA; ENSAA; AKT1; TRP53; CPD; SHC1; PPP2R2A; STRN; PPME1; PTPN1
Function protein phosphatase binding
Related Protein JAK1; PPP6R3; TRAF2; TRAF3; CDH5; IRS2; JAK3; AP3B1; DLG3; ROS1
Function protein self-association
Related Protein TNFAIP3; ABCD3; TMEM190; PROSAPIP1; EPB49; PCSK9; NKX3-1; TP53; DVL2; ACVR2A
Function receptor tyrosine kinase binding
Related Protein SOCS5; ZFP259; TRP53; LRP4; CPNE3; MYOC; PTPN11; PCNA; FLT3LG; ANGPT1
Function sequence-specific DNA binding
Related Protein NKX3.2; HOXD12A; CENPB; HNF1B; GATA1; NR2C2; RXRBB; SIX4B; ZNF192; WT1
Function transcription cofactor binding
Related Protein CHD6; TRP53; KLF4; FOXO3
Function transcription factor activity, sequence-specific DNA binding
Related Protein HIRA; GLI4; RBPJL; MEF2C; ZBTB14; PTTG1; ZNF37A; FOXG1A; MYRFL; NFE2L1A
Function transcription factor binding
Related Protein CCND1; NFKB1; HDAC3; E2F1; NKX3-1; ADD1; E2F2; HDAC9; PER1; TRAPPC2
Function transcription regulatory region DNA binding
Related Protein GLI1; THRA; ZFP513; NKX2; HMGB2; AIRE; TFE3; BCL11AA; HINFP; JUN
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NFATC3; ELK3; NR4A2; CAMTA1; SRF; TCF4; SOX2; SOX11; CEBPA; NR5A2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein MAFGB; REST; PAX9; BARX2; LMO2; CEBPA; EAF2; IRF2; HIF1A; GRHL2
Function ubiquitin protein ligase binding
Related Protein UBE2N; UBE2C; CXCR4; TRAF2; SQSTM1; CUL1B; BRCA1; PER3; EIF4E2; ASB4

Interacting Protein

Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.
lt_sv40; atp; Mdm2

Trp53 Related Articles

Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).