Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway PPP2R5D,FCER1A,AKT1,MAP2K2,PPP2R2A,ROCK2,SGPP2,MAPK10,BAX,FYN
    Non-small cell lung cancer EML4,MAPK3,RASSF1,RXRG,TGFA,PLCG1,RASSF5,PIK3R5,PIK3R1,PIK3CB
    Chronic myeloid leukemia IKBKG,PIK3CG,CCND1,MAPK3,GRB2,BRAF,MAPK1,AKT2,MAP2K2,CBLB
    p signaling pathway ATM,RRM2B,BAI1,GADD45AB,STEAP3,GADD45AA,TP53I3,SERPINB5,MDM2,CCND3
    Small cell lung cancer TRAF3,TRAF2,PIK3CD,LAMA4,RXRG,IKBKG,FN1,PIK3CA,COL4A1,BCL2L1
    Hepatitis B RELA,STAT3,PTK2B,PRKCG,NFATC2,Ifna15,EGR2,GRB2,STAT4,TLR4
    Glioma PIK3R3,PIK3R5,TGFA,RAF1,CALM1,MDM2,PIK3R2,MAP2K2,CAMK2G,SHC3
    Wnt signaling pathway CUL1A,FZD5,NKD2,TBL1XR1,TLE3A,DAAM1B,GSK3AA,MAPK9,DAAM1,GSK3B
    Amyotrophic lateral sclerosis (ALS) NOS1,Casp3,TNF,GRIN1,PPP3CB,PPP3R1,BID,ALS2,TNFRSF1B,BAX

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    p53 binding BRD4,HSPD1,RFWD3,RNF20,ZNF385A,TP53,SETD7,MAPKAPK5,RFFL,GATA1
    DNA binding HIST1H4A,SIX1A,ZNF501,PKNOX1.1,GM14483,ZFPM2,ZFP28,DLX3B,TADA2B,NR6A1B
    histone acetyltransferase binding HIF1A,CEBPB,EPAS1,KAT2B,ETS1,PCNA,GLI3,TAF7L,SIRT2,TRIM68
    protease binding LDLR,PANX1,A2M,RFFL,CD28,STIM1,SERPINA1A,BCL2,FURIN,IL1R1
    core promoter sequence-specific DNA binding SOX4,NRF1,THRAP3,NR1D2,SOX1,PROX1,ATF4,PRMT5,SP1,NFYA
    ATP binding CSNK2A2,GSK3AB,DNAJA4,KTI12,PPP1CA,ABCC12,MAPK14,ABCA1,NEK8,EIF2B2
    protein heterodimerization activity PPP1CBL,PRMT5,HMG20A,SMAD2,GABPB1,MLXIPL,USF2,TBX18,TCF3A,HMG20B
    MDM2/MDM4 family protein binding CDKN2A,PSME3,CDK5RAP3,PPARA,CAV1,RFWD3
    RNA polymerase II transcription factor activity, sequence-specific DNA binding ERG,ETV4,TFE3A,FOXG1B,RELB,RUNX2B,ETV5B,FLI1A,MEF2C,TFAP2D

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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