Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway LPAR5,GNG3,CREB3L1,FLT4,TNC,GRB2,FIGF,LPAR2,THBS1,GNG11
    Prostate Cancer IKBKB,AKT2,CREB3L1,ARAF,ARID1A,INS2,MTOR,ATF4,BAD,INS1
    Wnt signaling pathway BAMBIA,PPP3CA,WNT3,BTRC,TBL1Y,FZD8,CCND2A,CTBP2A,NFATC3,CCND3
    Central carbon metabolism in cancer HK2,PKM2,SLC2A1,TP53,PDHB,PIK3CA,MAPK3,FGFR1,PFKM,NRAS
    Bladder cancer RASSF1,CCND1,MAP2K2,E2F2,TP53,BRAF,MMP1,THBS1,MAP2K1,E2F1
    Glioma CALM1,CAMK2D,CALML5,PIK3R3,CAMK2B,MAPK1,PDGFRA,PDGFB,SHC2,SOS1
    Basal cell carcinoma SUFU,BMP4,GLI2,WNT16,FZD1,DVL2,GLI1,FZD6,WNT6,BMP2
    Small cell lung cancer LAMA5,BCL2,BCL2L1,PIK3R3,PIK3R5,PTEN,PIK3R2,LAMC1,CKS2,ITGB1
    Non-small cell lung cancer PLCG1,MAPK3,PIK3CA,RARB,PIK3R5,RXRB,TGFA,PIK3CG,KRAS,AKT1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding MEF2C,NFIA,TP63,ORC1L,CAMTA2,TCF3,EED,TCF7L1A,NR5A1B,PRIMPOL
    core promoter sequence-specific DNA binding SIRT1,PRMT5,SOX9,CHD2,H2AFY,NRIP1,MLL1,MTA1,CREM,ESR2
    metal ion binding ZFP36L3,ZFP580,MOBKL2B,ZNF143A,CAR3,DDHD1,B4GALT4,TENC1,ZNF395,ATP12A
    protease binding CSTA,MALT1,CNTNAP2,PINK1,MBL1,KIT,TP53,CCDC71L,Casp3,TIMP3
    identical protein binding KCTD17,NONO,STIM1,LDHA,FHIT,CCL4,SIRT1,TARDBP,KRTAP10-5,MNS1
    receptor tyrosine kinase binding ANGPT4,ELMO2,TP53,PLCG1,PITPNM3,PTPN14,NCK1,FNTA,Flt3l,PTPN11
    transcription factor activity, sequence-specific DNA binding ZFP14,HIC1,NFIL3,ZFP287,HSF2,CLOCK,GATAD2AB,KLF12,RNF4,FOXG1A
    sequence-specific DNA binding GATA1,PKNOX1.1,SPI1B,NKX2.3,ARNTL,CEBPG,BARHL1B,GLI2,RX3,FOXB1B
    p53 binding ZFP385C,RNF34,EP300,DUSP26,GSK3B,TAF1,EHMT1,GATA1,ANKRD1,CDKN2AIP

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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