Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyotrophic lateral sclerosis (ALS) CASP12,DERL1,TNF,GRIA1,BAD,NEFL,TOMM40,TOMM40L,DAXX,GRIN2C
    p signaling pathway ZMAT3,CASP8,RPRM,SIAH1,TNFRSF10B,PPM1DB,IGF1,CDK1,CASP9,COP1
    Transcriptional misregulation in cancer DOT1L,MEN1,KDM6A,CD86,Aff1,MAF,NUPR1,EYA1,HIST1H3D,FEV
    Endometrial cancer PIK3R1,TCF7L2,PIK3CB,MLH1,PIK3CG,CASP9,PIK3CA,CTNNA2,MAP2K1,AXIN1
    Measles Ifna15,IRF3,STAT1,CD3D,IFNA2,TNFAIP3,HSPA1L,cgr2b,CD28,PRKCQ
    Epstein-Barr virus infection IKBKG,GTF2B,HSPA1L,MAPK13,POLR2A,AKT1,YWHAZ,TRAF6,FGR,TBK1
    Viral carcinogenesis TRADD,GTF2A1,YWHAB,HIST2H4A,LYN,GTF2H4,HIST1H2BJ,HIST1H2BI,HIST1H2BL,DDX3X
    Hepatitis B AKT2,MAP2K4,TIRAP,PIK3R1,FASLG,NFATC1,EGR3,IKBKB,Ifna15,TGFB2
    Herpes simplex infection IFNA13,HLA-DRB5,MAVS,HLA-DRA,OAS1,IKBKG,TNFSF14,PVRL2,TLR9,GTF2IRD1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding PLCB1,SIRT1,MTA1,H2AFX,NPM2,LYN,ATP6AP2,HAND1,PICK1,IQCB1
    protein phosphatase 2A binding SPHK1,CTTNBP2NL,RPS6KB1,ARPP19,SMG7,PPME1,CPD,STRN,GRIN3A,MAPT
    protein phosphatase binding RPA2,STAT6,SHOC2,CTNNB1,JUP,VCP,PPP1R3G,ITGA1,MAP3K5,TRAF3
    protease binding LDLR,SERPINE1,RNF139,RYR1,PEO1,XBP1,CCDC71L,CHL1,TIMP2,DERL1
    metal ion binding HBAA1,PPM1BA,ANKMY2A,UBA2,GTPBP6,ESRRGB,ANTXR2B,ZNF295,CYP2A12,ERI3
    protein kinase binding PLK1S1,AKAP5,LIMS1,MAP3K2,SMAD3,CALM2,CD3E,TNNI3,CDKN2B,CACNB4
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXJ1,FLI1A,PLAG1,FOXB1,FOXD4L1,CC2D1B,FOXC1,PHB,FOXJ1B,EPAS1B
    protein heterodimerization activity CENPA,GABPA,PHC2B,HIST2H2AA4,H2AFX,SYT5,SNX2,SOX4,UGT1A1,MLXIPL
    RNA polymerase II core promoter sequence-specific DNA binding TFAP2A,SMAD1,SP3,TFAP2B,NLRC5,H2AFY,SMAD5,ZNF277,EP300,MTF1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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