Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection OAS1A,HCFC1A,EIF2AK4,PPP1CC,TAP1,CUL1B,TYK2,CASP3A,IFNA4,HLA-DQB1
    Melanoma TP53,FGF1,PDGFA,RAF1,MAP2K1,FGF16,FGF21,MET,FGF9,PIK3CB
    Sphingolipid signaling pathway PPP2R5C,BID,MAPK11,RAC1,PPP2R2C,SGPP2,CERS2,MAPK9,MAP2K2,RAF1
    Prostate Cancer HSP90B1,TCF7L2,ATF4,INSRR,NFKBIA,MAPK3,BCL2,EP300,GSK3B,CCNE1
    Basal cell carcinoma WNT5A,GLI3,TCF7,Shh,WNT9A,APC2,BMP4,FZD9,WNT7A,LEF1
    HTLV-I infection WNT3A,ATF3,PRKACA,CRTC2,ANAPC2,CREM,IKBKB,IL2RG,HLA-F,ITGB2
    Amyotrophic lateral sclerosis (ALS) TOMM40,PPP3CB,NEFH,PPP3CC,CYCS,GRIN2A,MAPK11,PPP3R1,MAP3K5,GRIN2B
    Apoptosis ATM,DIABLO,BCL2L11,CASP8L1,PRKAR2A,PRKAR1A,SPNA2,MYC,PRKACA,DSG2
    PIK-Akt signaling pathway LAMB2,Fasl,GNG2,Il4ra,PPP2R1A,TNR,Fgf15,INS,THBS2,KLK1B4

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein binding GNPDA2,APPL2,PNPT1,SYT16,PIH1D3,AKR1C1,TNFRSF11A,SEMA6A,SOX4,ADH1A
    RNA polymerase II core promoter sequence-specific DNA binding TCF7L2,RBPJ,H3F3B,SP3,NFIL3,SOX11,TBR1,H3F3A,H2AFY,SP1
    p53 binding GATA1,ZMAT3,TRIAP1,TRP63,USP10,ZNF385D,RNF20,SMYD2,AXIN1,ANKRD1
    receptor tyrosine kinase binding PTPN11,DNAJA3,GNB2L1,DOCK4,ANGPT1,Flt3l,SHC3,ANGPT4,FLT3LG,GAS6
    metal ion binding ZRANB3,ZNF705B,RHEBL1,GATA5,CSK,MORC2B,KLF10,GLRX5,PDLIM3A,TRIM35-23
    DNA binding AGFG1,ZNF285A,POLR2L,BLM,ZNF329,HIF3A,ZNF671,H2AFVA,ZNF497,ARID5A
    histone acetyltransferase binding MEF2A,HIF1A,EGR1,PCNA,MYOCD,ZBTB7A,MTF1,FOXP3,CITED2,TRIP4
    transcription cofactor binding CHD6,KLF4,FOXO3
    sequence-specific DNA binding IRX4A,HOXB4,ESRRGA,SPDEF,GATA1,ESRRA,HOXB13A,NFE2L2B,NKX6-1,IKZF1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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