Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle AHCTF1,NDC80,SETA,ANKLE2,NUPL2,RAD50,ESCO1,MAPRE1A,CUL1B,CHEK2
    Pathways in cancer BAX,GNG10,GNB1,PLCG2,PTCH1,BCL2,TGFB2,CYCS,XIAP,GNG3
    Measles IRF3,Il2,Fasl,HSPA6,IL2RA,IL1A,EIF2AK4,HSPA1L,cgr2b,IL12A
    Viral carcinogenesis VDAC3,HIST1H4E,HDAC3,ATP6V0D2,YWHAB,CCND2,ACTN4,YWHAZ,HIST1H2BJ,HDAC11
    Bladder cancer RPS6KA5,BRAF,SRC,RAF1,CCND1,E2F3,KRAS,MMP1,TP53,VEGFA
    Hepatitis B PIK3CB,IKBKG,SMAD3,Ifna15,RELA,MAP2K1,CCNA2,PRKCG,MAPK8,OSTN
    Transcriptional misregulation in cancer Pdgfa&Pdgfb,ZEB1,IL-8,IL2RB,CD40,PLAT,GOLPH3,RUNX2,HIST1H3C,NCOR1
    Herpes simplex infection CASP8,TAF5L,CFP,TLR3,MCRS1,TBPL1,H2-AB1,CD74,IFNA3,PVRL1
    Non-small cell lung cancer BRAF,PIK3CB,TGFA,ERBB2,RXRB,STK4,GRB2,AKT2,ALK,PIK3CA

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding PRKDC,CYP2A4,SLC18A1,CBX4,LYN,HDHD2,HYAL2,PIAS3,LUC7L2,CYP1A1
    receptor tyrosine kinase binding SHC4,FLT3LG,PTPN1,ANGPT4,CPNE3,ELMO2,GAS6,LRP4,PTPN14,ANGPT2
    transcription factor activity, sequence-specific DNA binding PCGF6,ATF6B,RFXANK,DMRT3A,KLF1,SMAD7,TEAD2,GCM2,RUNX1T1,POU5F2
    transcription regulatory region DNA binding SMAD4,TP63,WT1,PRDM5,NKX3-1,TBL1XR1,MSX2,ZNF174,FOXA1,TBP
    protein binding CPSF2,TNFRSF12A,TAE1,NEK8,GAPDHS,TCEA1,PDE3B,RTN1,MT1H,USP25
    protein phosphatase binding NEK2,FGF19,SHOC2,STAT3,FLT4,ERBB2,ANAPC7,JAK1,EGFR,CTNNB1
    double-stranded DNA binding HMGB3,MTERFD2,IFI203,RAD51L3,FEV,MTERFD1,RAD51B,MCM10,TEF,AFF3
    DNA binding DMBX1A,FOXQ1A,RAD51B,DNMT3A,CERS4A,KDM5BB,ZFP628,TOX,NANOG,HDGF
    sequence-specific DNA binding NFIL3-5,NR1D2A,GSC,RXRAA,SOX7,HOXA10B,HOXC8,NKX3.2,PAX6A,RBPJ

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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