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Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl; bfy; bhy; p44; p53; Tp53;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Trp53 Related Articles

Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPM1A;MAP3K12;PDGFAA;ARRB2B;KCNA3;MAP2K2B;PRKCG;FGF12A;CACNA2D3
Sphingolipid signaling pathwayS1PR4;RAF1;SPTLC3;PLCB4;PPP2R5C;MAPK8;PPP2R2B;FCER1G;ROCK1
Cell cycleFGFR1OP;NSL1;MAD1L1;ESPL1;MCM7;HAUS2;CDKN2A;CDC25C;GADD45G
p signaling pathwayEI24;SIAH1;GTSE1;PERP;GADD45AA;SERPINE1;RRM2;TNFRSF10B;Casp3
PIK-Akt signaling pathwayFGF17;PCK1;ITGB4;PPP2R2B;RPS6KB2;MAP2K1;INS;LAMA4;MLST8
ApoptosisIL1B2;ATM;CTNNB1;TNFRSF10C;BCAP31;CASP6L2;FAS;BNIP3LB;PRKACA
Wnt signaling pathwayNLK;PRKACB;WNT5A;FZD7A;PLCB4;BAMBIA;FOSL1;WNT6;DKK1B
Neurotrophin signaling pathwaySHC4;SH2B3;MAP3K1;FASLG;RHOA;MAPK3;RPS6KA3;CDC42;ARHGDIG
Thyroid hormone signaling pathwayTHRB;PIK3R1;MED4;SRC;HDAC1;HDAC2;TSC2;NOTCH4;PRKACG
Amyotrophic lateral sclerosis (ALS)TP53;APAF1;GRIA1;BCL2L1;CYCS;SOD1;GRIN2D;NOS1;TOMM40
Huntingtons diseaseHAP1;DNAH14;POLR2H;SOD2;SDHD;NDUFA3;MT-ATP6;CASP9;DNAH5
Hepatitis CPPP2R2A;OSTN;TNF;IFNA5;IRF3;PIK3CD;NRAS;TRADD;RNASEL
Hepatitis BIFNA21;APAF1;ATF4;PIK3CG;IKBKB;HSPG2;TGFBR1;STAT2;MAP2K1
MeaslesIFNA21;RELA;TNFRSF10C;NFKB1;IKBKE;FASLG;IL12A;IFNA1;NFKBIB
HTLV-I infectionWNT16;NFYB;PTTG2;EGR2;H2-Q10;FZD7;PPP3R2;CANX;SRF
Herpes simplex infectionSRSF6B;SRSF9;IFNA3;MHC1UEA;FAS;TAF5;HLA-DQA1;TLR2;SOCS3B
Epstein-Barr virus infectionFcer2a;GTF2B;YWHAE;PSMD3;POLR2K;PSMC3;CR2;MAP2K4;PSMC6
Pathways in cancerWNT5B;WNT7A;HSP90B1;ARNT2;LAMA4;HSP90AB1;FGF14;FADD;FGF1
Transcriptional misregulation in cancerMDM2;HIST2H3A;TRAF1;SIN3A;PROM1;ELK4;MLF1;CD14;RXRA
Viral carcinogenesisHDAC10;HIST2H2BE;SRF;RBL2;PIK3CG;KRAS;HIST1H2BQ;HIST2H4;ATP6V0D2
Proteoglycans in cancerMAP2K1;MDM2;TLR4;FZD8;PIK3CG;CAMK2G;IGF1R;ACTB;Fzd4
MicroRNAs in cancerPRKCB;DICER1;BCL2L2;NOTCH1;MCL1;FZD3;PDGFB;PTEN;IKBKB
Colorectal cancerPIK3CD;RAF1;Casp3;TGFB1;PIK3CG;PIK3CB;FOS;PIK3R1;TGFB3
Pancreatic cancerCCND1;BAD;ARAF;ARHGEF6;STAT3;ERBB2;RALBP1;TGFB3;MAPK3
Endometrial cancerCTNNA3;PIK3R3;CASP9;BRAF;AXIN1;TP53;SOS1;PIK3R1;APC
GliomaMAPK3;PIK3CD;MAPK1;HRAS;PLCG2;GRB2;CCND1;PIK3R3;PDGFA
Prostate cancerPIK3CD;ARAF;PDGFA;TCF7L2;FGFR1;FOXA1;SMARCA4;FOXO1;NFKB1
Thyroid cancerNTRK1;TPR;NRAS;TCF7;MAPK1;RXRG;MAP2K1;KRAS;RXRA
Basal cell carcinomaWNT5A;FZD9;WNT3A;WNT2B;WNT9A;PTCH1;Shh;WNT8B;HHIP
MelanomaCDH1;MAPK1;RAF1;PIK3R2;MDM2;FGF9;PIK3R1;PDGFA;FGF22
Bladder cancerMAPK1;DAPK3;CDH1;HBEGF;MAP2K2;E2F1;RB1;ERBB2;DAPK2
Chronic myeloid leukemiaPIK3CA;NRAS;RELA;SHC2;CRK;PIK3R3;AKT2;BRAF;SHC3
Small cell lung cancerRXRB;LAMA5;PIK3CD;IKBKB;PTGS2;ITGA2;PIK3R5;LAMC2;PIK3R1
Non-small cell lung cancerRARB;BRAF;TP53;MAPK3;EML4;ARAF;PLCG1;HRAS;MAP2K2
Central carbon metabolism in cancerC12orf5;SCO2;PDHA2;PDHB;PDK1;HIF1A;AKT1;MAPK3;SLC16A3

Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPIK3C2B;YTHDC2;TOP2A;HSPH1;CSNK1D;UBE2NA;CHST13;FARSB;ACVR2AA
DNA bindingPAX8;POLM;VEPH1;MBD1B;SURF6;PROX1A;AHR2;HIST1H2BM;LRRFIP1
MDM2/MDM4 family protein bindingPPARA;CDK5RAP3;RFWD3;CAV1;PSME3;CDKN2A;TRP53
RNA polymerase II core promoter sequence-specific DNA bindingEP300;TBR1;TAL1;EGR1;HNF4A;SFPI1;IRF7;ZNF335;ZFP335
RNA polymerase II regulatory region sequence-specific DNA bindingPCGF6;ETV6;SOX13;POU3F4;CSDA;AIRE;FOXF2;LMO2;NEUROD2
RNA polymerase II transcription factor activity, sequence-specific DNA bindingERG;FOXI3A;NFIB;SOX30;HIF1AL;TFDP3;SP4;XBP1;FOXO3B
RNA polymerase II transcription factor bindingTOX2;NFATC1;TAL1;MEF2A;SMAD4;TRP53;TRPS1;TEAD3;GATA4
chaperone bindingTBCC;TIMM10;CDC37L1;PACRG;Alb;PFDN6;HSP104;VWF;SERPINA7
chromatin bindingPARP1;DNAJC2;RNF168;EGFR;ISL1;GLI3;ZGLP1;NKX6-1;SETD7
copper ion bindingPRND;MOXD1L;S100V2;SNCA;SLC11A2;HEPH;TYRP1;ADNP;LOXL5B
core promoter sequence-specific DNA bindingTRP53;ZFHX3;SOX9;PRMT5;CREM;PROX1;NR1D2;SOX1;CRY1
damaged DNA bindingRPA2;FEN1;APTX;POLD1;POLB;ERCC1;TP53;OGG1;RPS3
double-stranded DNA bindingRAD51D;MTERFD1;FBXO18;PYDC3;TDP1;MTERFD2;HMGB2;KIN;USF1
enzyme bindingCYP1A2;A2M;NOTCH1;PLSCR1;NCOA1;PARP4;MAT2B;NR5A1;RAD9A
histone acetyltransferase bindingSP1;CITED2;PCNA;TAF7L;HIF1A;PAX6;ZBTB7A;ETS1;MEF2A
histone deacetylase regulator activityTP53;NCOR1;MAPK8;TRP53
identical protein bindingSERPINA1A;KCTD13;VWA2;NOL3;SH3GL2;PTEN;APOH;FBLN1;DHX8
metal ion bindingPLA2G4F;ZNF865;NEK2;LRP2;RHEBL1;ZFP354B;ZXDB;GALNS;ATP8A1
p53 bindingTRIM24;RNF34;PTTG1IP;BCL2L12;CHD8;NTRK3;GATA1;DAXX;TAF9
protease bindingBCL10;LDLR;Cstb;CAST;A2M;FLOT1;ITGA3;TRIP4;HSPD1
protein C-terminus bindingPXK;BLOC1S2A;ECM1;C11orf60;PEX26;PEX16;PEX10;CALCOCO1;MAPRE1
protein N-terminus bindingTBL1XR1;VWF;MEN1;PDCD10;MNAT1;STX5;STX1A;SCFD1;TDRD7
protein bindingDNAI2;EPS8;MRE11A;C10orf18;FAM90A1;C16orf87;TIFA;PHB2;SLC6A3
protein heterodimerization activityWHRN;ERBB3;MAFG;NEFH;PDX1;USF2;BMP6;POU5F3;SOX32
protein kinase bindingCDKN2D;PEBP1;DPYSL2;DNM2;PTPRR;SLC12A4;TTN;CDK5;TUBB3
protein phosphatase 2A bindingMAPT;CPD;ENSA;ARPP19;CTTNBP2NL;RPS6KB1;TRP53;SPHK1;GRIN3A
protein phosphatase bindingTRP53;ANAPC5;ITPR1;CDC27;MAPK14;CTNNB1;ITGA1;EIF2AK3;NEK2
protein self-associationSLC9A3R1;MDH2;AXIN1;DYRK1A;SYP;ACHE;ZSWIM2;TNFAIP3;BCL10
receptor tyrosine kinase bindingFIZ1;TRP53;ANXA5;HYAL2;SHC3;NRG3;PITPNM3;ZFP259;Flt3l
sequence-specific DNA bindingFOXJ3;NR5A5;HOXC3A;PBX1B;HOXB6;NKX3-1;ENG1B;POU2F1;GBX1
transcription cofactor bindingCHD6;FOXO3;TRP53;KLF4
transcription factor activity, sequence-specific DNA bindingZNF263;MAX;ZFP131;E2F3;ZFP628;ZKSCAN1;CSRNP1;ZNF232;TEAD3B
transcription factor bindingDNMT1;MDFIC;PDX1;FOS;ZBTB49;CREG1;SMARCA4;LEF1;VDRA
transcription regulatory region DNA bindingRCOR1;WT1;PPARG;CBX4;TA;SOX17;NFKB1;LEF1;SIX1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingMESP1;FIGLA;NFIC;ARID3B;HOXC11;HNF4A;ZFP750;ATOH1;SMAD4
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingZGLP1;LMO2;ETV5;SOX17;HIF1A;SOHLH2;MAFBB;TRPS1;OVOL2
ubiquitin protein ligase bindingUSP13;BECN1;ASB4;KCNH2;TANK;CDC34B;PRKAR1A;RRAGA;GPR19

Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

lt_sv40; atp; Mdm2

Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).
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