Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis PIK3R3,PIK3R5,IKBKG,IRF2,IL3,PANK1A,TNF,PRKACAB,BIRC3,PPP3R2
    Glioma AKT2,CAMK2A,CAMK2G,PRKCB,SOS1,PIK3CB,MAPK1,GRB2,SHC2,SHC1
    MAPK signaling pathway FGFR1,FGF12A,PRKCBA,HSP70L,Fgf15,ZAK,RPS6KA4,TRAF2,NRAS,RRAS
    HTLV-I infection RELA,WNT9A,APC,IL15,FZD3,WNT8A,ANAPC1,WNT7B,TGFBR2,KAT2A
    Thyroid hormone signaling pathway PLCD4,PLCD1,RCAN1,MED27,NOTCH4,ATP1A1,SIN3A,SRC,NOTCH1,PFKP
    Epstein-Barr virus infection PSMD8,MAP3K14,NCOR2,HLA-DRB5,HLA-DPA1,SND1,ICAM1,DDX58,RELB,PSMD7
    Amyotrophic lateral sclerosis (ALS) TNF,CCS,MAP2K6,BAX,TOMM40,BID,NEFL,PPP3R1,GRIN1,RAC1
    Thyroid cancer MAP2K2,RXRG,BRAF,NCOA4,PPARG,CCND1,RXRA,MAPK1,TFG,NTRK1
    Pancreatic cancer CCND1,RAF1,RB1,RALGDS,PIK3CB,STAT3,PIK3CG,PIK3R2,MAPK8,RALB

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXB1A,FOXD4L1,FOXJ3,SOX5,PLAGX,OVOL3,TWIST1,SP3,ATF4,ZNF446
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding NR1I3,GATA6,NEUROD2,FOXF1,CREB3L4,IKZF3,ATF5,MAFBA,ONECUT3,ALX1
    core promoter sequence-specific DNA binding H2AFY,REST,NR1D2,MYOCD,KLF10,PRMT5,ZFHX3,CREM,PPARG,ZNF750
    identical protein binding PCM1,ECI1,CD74,CRYAA,UGP2,PARP1,WAS,KCTD17,SID4,SMAD1
    protein heterodimerization activity TCF3,PPARD,SYT10,KCNK3,BNIP3L,TPD52L1,CAV2,TYRP1,BIRC5,TLR1
    protein self-association PCSK9,PTH1R,DYRK1A,ZFP639,SLC2A1,SLC9A3R1,AGTR1A,TNFAIP3,RYR2,PABPN1
    ubiquitin protein ligase binding YWHAE,CASP10,CUL3,AKTIP,UBE2J1,CUL5,PRDX6,GABARAPL1,POU5F1,TUBA1B
    receptor tyrosine kinase binding PTPN2,FIZ1,ANGPT2A,ZNF259,NRG3,TP53,FLT3LG,TOB1,NRG1,SOCS5
    double-stranded DNA binding SP1,TRP63,AIM2,RAD51C,ERCC5,CGGBP1,MTERFD3,HMGB1,GTF2H4,HMGB3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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