|Official Full Name||tuberous sclerosis 2|
|Background||Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]|
|Synonyms||TSC2; tuberous sclerosis 2; LAM; TSC4; tuberin; tuberous sclerosis 2 protein;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway, p signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Phospholipase D signaling pathway||Kitl; PLCB4; PTGFR; DGKZ; AVPR1A; CXCR2; RRAS2; PLCG2; RHEB; AGPAT3|
|p signaling pathway||PPM1DB; LRDD; BBC3; SERPINE1; CASP9; CDK1; GADD45BA; CCND2; CCNE2; RRM2|
|mTOR signaling pathway||PRR5; AKT2; PIK3CA; RPS6KB1; PRKCA; PIK3R2; EIF4BA; PRKCG; PIK3R5; RPS6KA6|
|PIK-Akt signaling pathway||IKBKG; PRLR; INS; YWHAB; GHR; COL6A5; IFNA16; CCNE1; YWHAZ; HSP90AB1|
|AMPK signaling pathway||EEF2; PFKM; ADIPOR1; PPP2R5C; ACACB; IRS2; PFKL; PRKAB1; CRTC2; PFKFB1|
|Insulin signaling pathway||PPP1R3A; CALML5; CALM3B; PIK3R3A; RHOQ; G6PC2; PKLR; INSB; PRKAB1; CALM4|
|Thyroid hormone signaling pathway||DIO2; PRKCG; PLCD4; MED14; ITGAV; MED12; PRKACA; PFKP; MAP2K2; ATP1B2|
|Choline metabolism in cancer||PLA2G4B; PIK3R5; PIK3CA; CHKB; TAE1; EIF4EBP1; PIK3R3; DGKG; WAS; DGKA|
TSC2 has several biochemical functions, for example, 14-3-3 protein binding, GTPase activator activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.
|14-3-3 protein binding||ARRB2; KIF13B; PRKCZ; IRS2; SRPK2; KCNH1; AANAT; TSC2; HDAC7A; ZFP36|
|GTPase activator activity||ARFGAP1; RGS4; DLC1; ARHGAP42A; GMIP; TBC1D17; ARHGAP8; TSC2; CDC42EP5; PLCB1|
|phosphatase binding||PPARA; MAGI2; ELFN2; MAST2; CNST; MAPK3; ELFN1; TSC2; PPP1R37; CTSC|
|protein binding||EPCAM; PSMD11; CD93; UBA3; EID3; EPRS; DNM1; IPO4; NVL; GCG|
|protein homodimerization activity||FAM109B; DPYD; LRRC41; GRIK2; Pdgfa&Pdgfb; CITED1; APOA1BP; NRF1; RRAGA; ALDH5A1|
|small GTPase binding||RNF152; PEX5L; FGD1; ERRFI1; FGD3; FGD6; TSC2; FGD4; FGD5; ABCA1|
TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.