TSC2 Protein, tuberous sclerosis 2


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Official Full Name tuberous sclerosis 2
Background Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms TSC2; tuberous sclerosis 2; LAM; TSC4; tuberin; tuberous sclerosis 2 protein;
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TSC2-31631TH Recombinant Human TSC2, His-tagged E.coli His
    Rat TSC2-6310R Recombinant Rat TSC2 Protein Mammalian Cell His
    Zebrafish TSC2-4633Z Recombinant Zebrafish TSC2 Mammalian Cell His
    Zebrafish TSC2-6386Z Recombinant Zebrafish TSC2 Mammalian Cell His

    TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway, p signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway Kitl; PLCB4; PTGFR; DGKZ; AVPR1A; CXCR2; RRAS2; PLCG2; RHEB; AGPAT3
    p signaling pathway PPM1DB; LRDD; BBC3; SERPINE1; CASP9; CDK1; GADD45BA; CCND2; CCNE2; RRM2
    mTOR signaling pathway PRR5; AKT2; PIK3CA; RPS6KB1; PRKCA; PIK3R2; EIF4BA; PRKCG; PIK3R5; RPS6KA6
    PIK-Akt signaling pathway IKBKG; PRLR; INS; YWHAB; GHR; COL6A5; IFNA16; CCNE1; YWHAZ; HSP90AB1
    AMPK signaling pathway EEF2; PFKM; ADIPOR1; PPP2R5C; ACACB; IRS2; PFKL; PRKAB1; CRTC2; PFKFB1
    Insulin signaling pathway PPP1R3A; CALML5; CALM3B; PIK3R3A; RHOQ; G6PC2; PKLR; INSB; PRKAB1; CALM4
    Thyroid hormone signaling pathway DIO2; PRKCG; PLCD4; MED14; ITGAV; MED12; PRKACA; PFKP; MAP2K2; ATP1B2
    Choline metabolism in cancer PLA2G4B; PIK3R5; PIK3CA; CHKB; TAE1; EIF4EBP1; PIK3R3; DGKG; WAS; DGKA

    TSC2 has several biochemical functions, for example, 14-3-3 protein binding, GTPase activator activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding ARRB2; KIF13B; PRKCZ; IRS2; SRPK2; KCNH1; AANAT; TSC2; HDAC7A; ZFP36
    GTPase activator activity ARFGAP1; RGS4; DLC1; ARHGAP42A; GMIP; TBC1D17; ARHGAP8; TSC2; CDC42EP5; PLCB1
    phosphatase binding PPARA; MAGI2; ELFN2; MAST2; CNST; MAPK3; ELFN1; TSC2; PPP1R37; CTSC
    protein binding EPCAM; PSMD11; CD93; UBA3; EID3; EPRS; DNM1; IPO4; NVL; GCG
    protein homodimerization activity FAM109B; DPYD; LRRC41; GRIK2; Pdgfa&Pdgfb; CITED1; APOA1BP; NRF1; RRAGA; ALDH5A1
    small GTPase binding RNF152; PEX5L; FGD1; ERRFI1; FGD3; FGD6; TSC2; FGD4; FGD5; ABCA1

    TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.


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