ttc5
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  • Official Full Name
  • tetratricopeptide repeat domain 5
  • Background
  • Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats. Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those seen with protein chaperones HSP70 and HSP90 and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5, suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.
  • Synonyms
  • TTC5; tetratricopeptide repeat domain 5; tetratricopeptide repeat protein 5; OTTHUMP00000163990; OTTHUMP00000163991; TPR repeat protein 5; Strap
Cat.#:TTC5-17575MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TTC5 Protein
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Cat.#:TTC5-6344RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TTC5 Protein
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Cat.#:TTC5-2421ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TTC5
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Cat.#:TTC5-1856HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TTC5 cell lysate
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Involved Pathway

TTC5 involved in several pathways and played different roles in them. We selected most pathways TTC5 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTC5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p53 pathway
RASSF1; CSNK1G3; KAT8; HUWE1; TRIM28; SMYD2; FBXO11; TTC5; DYRK2; PPP1R13L

Protein Function

TTC5 has several biochemical functions, for example, DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTC5 itself. We selected most functions TTC5 had, and list some proteins which have the same functions with TTC5. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein MCM3; THAP3; TOP1; TCF15; MTF1; HES4; G3BP1; SSRP1A; HOXA9A; ZBED5
Function chromatin binding
Related Protein POLG; TRPS1; JUB; PHF21B; NR5A5; NSD1; PARP1; RFX4; JUN; TRP53
Function protein binding
Related Protein RNASEL; NDUFS7; SELPLG; PSMD14; THAP11; ATP2B4; FAM60A; ZKSCAN3; DDRGK1; ADAM23

Interacting Protein

TTC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TTC5.
CAMK2B; CAMK2D; HSF1; EP300

TTC5 Related Articles

Xiong, Y; Wang, L; et al. Human TTC5, a novel tetratricopeptide repeat domain containing gene, activates p53 and inhibits AP-1 pathway. MOLECULAR BIOLOGY REPORTS 40:6183-6188(2013).
Lynch, JT; Somerville, TDD; et al. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. CELL DEATH & DISEASE 4:-(2013).