u2af1
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  • Official Full Name
  • U2 small nuclear RNA auxiliary factor 1
  • Background
  • This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • U2AF1; U2 small nuclear RNA auxiliary factor 1; U2(RNU2) small nuclear RNA auxiliary factor 1 , U2(RNU2) small nuclear RNA auxiliary factor binding protein , U2AFBP; splicing factor U2AF 35 kDa subunit; RN; RNU2AF1; U2AF35; splicing factor U2AF 35kDa sub
Cat.#:U2AF1-580HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human U2 small nuclear RNA auxiliary factor 1, His-tagged
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Cat.#:U2AF1-6223CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken U2AF1
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Cat.#:U2AF1-9571ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish U2AF1
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Cat.#:U2AF1-609HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human U2AF1 293 Cell Lysate
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Involved Pathway

U2AF1 involved in several pathways and played different roles in them. We selected most pathways U2AF1 participated on our site, such as Spliceosome, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with U2AF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
SNRPA; SFRS9; LSM8; SF3B4; PCBP1; BCAS2; EIF4A3; ISY1; SNRNP200; SMX5
Shigellosis
VCL; ABL1; FBXW11; ELMO1; ITGB1; DIAPH1; SRC; BTRC; PFN1; CTTN

Protein Function

U2AF1 has several biochemical functions, for example, metal ion binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by U2AF1 itself. We selected most functions U2AF1 had, and list some proteins which have the same functions with U2AF1. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein CYP2C38; ZSCAN2; ZNF624; THAP6; XIRP2; TIMM8B; PVALB6; LRP2; ZBTB49; ZFP42
Function nucleotide binding
Related Protein ABCC12; RHOAD; NSFA; TRA2A; RBM26; MYH1; PRKCHA; TTLL2; ATP1A3A; CELF1
Function poly(A) RNA binding
Related Protein DDX31; ANXA2; MRPS28; RPL37A; TBCA; STIP1; FUS; DIMT1L; GNL3; RPL8
Function protein binding
Related Protein RSPO2; CDC37L1; PFKL; MTM1; MSLN; ZSCAN16; WDR77; NDUFAF4; SULT1A3; SEPT10

Interacting Protein

U2AF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with U2AF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of U2AF1.
U2AF2; SRPK2; CIR1