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U2AF1

Official Full Name

U2 small nuclear RNA auxiliary factor 1
Overview

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

U2AF1; U2 small nuclear RNA auxiliary factor 1; U2(RNU2) small nuclear RNA auxiliary factor 1 , U2(RNU2) small nuclear RNA auxiliary factor binding protein , U2AFBP; splicing factor U2AF 35 kDa subunit; RN; RNU2AF1; U2AF35; splicing factor U2AF 35kDa sub;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	U2AF1-580H	Recombinant Human U2 small nuclear RNA auxiliary factor 1, His-tagged	E.coli	His		Inquiry
Human	U2AF1-609HCL	Recombinant Human U2AF1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	U2AF1-581H	Recombinant Human U2AF1 protein, GST-tagged	E.coli	GST	26-240 aa	$319 / 25ug
Zebrafish	U2AF1-9571Z	Recombinant Zebrafish U2AF1	Mammalian Cell	His		Inquiry
Chicken	U2AF1-6223C	Recombinant Chicken U2AF1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

U2AF1 involved in several pathways and played different roles in them. We selected most pathways U2AF1 participated on our site, such as Spliceosome, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with U2AF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Spliceosome	HSPA2;ISY1;HNRNPK;SNRPE;RP9;SYF2;SF3A2;SNW1;DHX15
Shigellosis	IKBKB;CTTN;DIAPH1;UBE2D2;ROCK1;RAC1;SRC;RELA;CDC42

U2AF1 has several biochemical functions, for example, metal ion binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by U2AF1 itself. We selected most functions U2AF1 had, and list some proteins which have the same functions with U2AF1. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	PDE5AB;MOB4;ZNF501;RBM4.1;ZNF48;METAP1D;ATP1A1A.4;MMP23BB;CYP26C1
nucleotide binding	CLK4B;HNRNPA0A;PRAC;CELF5A;RALAB;HNRNPA1B;MVDA;TARDBP;PANK1A
poly(A) RNA binding	MFAP1;ADARB1;MOV10;EIF4A3;CLNS1A;TES;ZCCHC9;SSRP1;H1FX
protein binding	PTRH2;ERP27;CFTR;NAT10;SERTAD1;SIPA1L2;NDUFAF1;ANXA10;PRKRIP1

U2AF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with U2AF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of U2AF1.

U2AF2; SRPK2; CIR1