UBA1
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Official Full Name
ubiquitin-like modifier activating enzyme 1
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Overview
Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which targets a protein for degradation via a proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-transcriptional modification by ubiquitin and ubiquitin-like proteins. -
Synonyms
UBA1; ubiquitin-like modifier activating enzyme 1; A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; MGC4781; ubiquitin-like modifier-activating enzyme 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf9 Insect Cell
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- UBA1 Related Research Area
UBA1 involved in several pathways and played different roles in them. We selected most pathways UBA1 participated on our site, such as Ubiquitin mediated proteolysis, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CBLB;BIRC8;ANAPC13;NEDD4;TRIM37;CDC20;MID1;SAE1;KLHL9 |
| Parkinsons disease | UQCRC2;SDHA;COX7A2L;UCHL1;ATP5B;NDUFAB1;COX4I2;COX6A2;VDAC1 |
UBA1 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA1 itself. We selected most functions UBA1 had, and list some proteins which have the same functions with UBA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCF2A;CLK1;ACSM1;RPS6KA4;FARSB;UBA1;PRKACBB;UBE2Q2;ATP7B |
| poly(A) RNA binding | MKRN1;MRPL11;ZFP106;UTP15;RPL24;MPHOSPH10;RBM5;EFTUD2;AKAP8L |
| protein binding | PTPRA;IL11;CABP1;TRIM28;SCARA3;SCRN1;PVR;RTN2;SGIP1 |
| ubiquitin activating enzyme activity | UBA1;UBA6;UBE1Y1;ATG7;SAE1;UBA7 |
| ubiquitin-protein transferase activity | FBXL6;FBXO2;BIRC2;TRIM2;TRIM5;RNF5;SIAH1;UBE2N;HECW2 |
UBA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA1.
GAN; BIRC3; MAGEC2; q76353_9hiv1; CCDC69; YAF2; HIP1; RIOK3; HGS; MDM4; RNF13; HIP1R; DNAJB6
- Q&As
- Reviews
Q&As (5)
Ask a questionSome early-phase clinical trials are exploring UBA1 as a potential target in the context of ALS and cancer.
Targeting UBA1 with small molecules or gene therapy may provide a potential avenue for treating UBA1-related diseases.
UBA1 activates ubiquitin, a small protein that tags other proteins for degradation by the proteasome.
UBA1 dysfunction has been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and certain types of cancer.
Research suggests that altered UBA1 levels in the cerebrospinal fluid may be a potential biomarker for ALS diagnosis.
Customer Reviews (3)
Write a reviewThe UBA1 protein comes highly recommended for its outstanding performance in various experimental applications.
In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.
Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the UBA1 protein in my studies.
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