|Official Full Name||ubiquitin-conjugating enzyme E2E 1|
|Background||The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.|
|Synonyms||UBE2E1; ubiquitin-conjugating enzyme E2E 1; ubiquitin conjugating enzyme E2E 1 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 E1; UbcH6; UB2E1_HUMAN; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1; OTTHUMP00000161049; OTTHUMP00000161050; OTTHUMP00000208307; OTTHUMP00000208308; OTTHUMP00000208309; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5)|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
UBE2E1 involved in several pathways and played different roles in them. We selected most pathways UBE2E1 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ubiquitin mediated proteolysis||TCEB1; UBE1Y1; UBE2M; UBE2R2; UBA1; PIAS4; SKP2; CUL4A; CBLB; UBE2QL1|
|Protein processing in endoplasmic reticulum||UBQLN3; MAPK9; CAPN1; HSPA1A; CAPN2L; BCL2A; YOD1; MAN1A1; EIF2AK4; FBXO6|
UBE2E1 has several biochemical functions, for example, ATP binding, ISG15 transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2E1 itself. We selected most functions UBE2E1 had, and list some proteins which have the same functions with UBE2E1. You can find most of the proteins on our site.
|ATP binding||PFKFB4; PIP5KL1; RLN1; FLT1; BAZ1B; UBE2N; MINK1; ERCC2; MCM3L; MVD|
|ISG15 transferase activity||HERC5; UBE2E1; UBE2E2; UBE2L6|
|protein binding||KIAA0408; FBXO7; SNTB1; ALKBH3; PLK1; KIAA1530; GGACT; ATP6V1C1; ITGA2B; DNAJB6|
|ubiquitin conjugating enzyme activity||UBE2D1; UBE2Q2; UBE2T; UBE2O; UBE2N; UBE2H; CDC34; UBE2D4; UBE2QL1; UBE2E1|
|ubiquitin-protein transferase activity||CBLL1; RNF13; ANKIB1; TRAF6; RNF144AB; MARCH8; TRAF4; FBXL3; UBE2E3; UBE3C|
UBE2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2E1.
ZNRF1; ospG; RNF111; RNF25; RNF5; RNF167; RNF11; PAF1; UBA1; UBE2N