ube2g1
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2G 1
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived;proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or;E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the;E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The;protein may be involved in degradation of muscle-specific proteins.
  • Synonyms
  • UBE2G1; ubiquitin-conjugating enzyme E2G 1; UBE2G, ubiquitin conjugating enzyme E2G 1 (homologous to C. elegans UBC7) , ubiquitin conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) , ubiquitin conjugating enzyme E2G 1 (UBC7 homolog, yeast); ubiquitin-
Cat.#:UBE2G1-267HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2G1, His-tagged
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Cat.#:UBE2G1-3534HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2G1, GST-tagged
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Cat.#:UBE2G1-648HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2G1 Protein, His-tagged, Active
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Cat.#:UBE2G1-667HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ubiquitin-conjugating enzyme E2G 1, His-tagged
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Cat.#:UBE2G1-854HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2G1, None tagged
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Cat.#:UBE2G1-17716MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBE2G1 Protein
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Cat.#:UBE2G1-6400RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UBE2G1 Protein
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Cat.#:UBE2G1-1074CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus UBE2G1 Protein, His-tagged
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Cat.#:UBE2G1-3638CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UBE2G1
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Cat.#:UBE2G1-09HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin Conjugating Enzyme 7
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Cat.#:UBE2G1-579HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2G1 293 Cell Lysate
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Involved Pathway

UBE2G1 involved in several pathways and played different roles in them. We selected most pathways UBE2G1 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2G1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
PML; CDC34; UBE2B; MGRN1A; TRIM37; KEAP1; TRIP12; UBE2KA; WWP2; TRAF6
Protein processing in endoplasmic reticulum
EDEM2; FBXO2; SEL1L; MAPK8B; HSP70L; XBP1; UGGT1; VCP; DNAJA1; SEC61G
Parkinsons disease
NDUFB10; NDUFS4; NDUFS8; ATP5J; NDUFC1; PPIF; UQCRFS1; ATP5A1; NDUFB2; COX7A2L

Protein Function

UBE2G1 has several biochemical functions, for example, ATP binding, ubiquitin conjugating enzyme activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2G1 itself. We selected most functions UBE2G1 had, and list some proteins which have the same functions with UBE2G1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2NB; ADRBK1; TTLL1; HIPK3A; ACACB; SMARCAD1; CSNK1E; KALRN; UBE2G2; SKIV2L
Function ubiquitin conjugating enzyme activity
Related Protein UBE2D2; UBE2V2; UBE2E2; UBE2D3; UBE2Q1; UBE2R2; UBE2E1; UBE2H; UBE2D2A; UBE2E3
Function ubiquitin protein ligase activity
Related Protein UBE2S; UBE2G2; RNF13; FLJ11011L; SIAH1; HECTD3; TMEM189; TRIM6; FBXW11; NHLRC1
Function ubiquitin protein ligase binding
Related Protein TMEM173; UBE2A; IKBKG; KCNQ3; FBXW7; UBE2S; ARRB2; SNCAIP; CCT2; PA2G4
Function ubiquitin-protein transferase activity
Related Protein BIRC5; RNF182; MYCBP2; TRIM36; UBE2D3; FBXL6; RLIM; MARCH8; PJA2; BIRC8

Interacting Protein

UBE2G1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2G1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2G1.
CUL1; RBCK1; Tmed10

UBE2G1 Related Articles

Choi, YS; Lee, YJ; et al. Differential Ubiquitin Binding by the Acidic Loops of Ube2g1 and Ube2r1 Enzymes Distinguishes Their Lys-48-ubiquitylation Activities. JOURNAL OF BIOLOGICAL CHEMISTRY 290:2251-2263(2015).
Evangelou, M; Smyth, DJ; et al. A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations. GENETIC EPIDEMIOLOGY 38:661-670(2014).