• Official Full Name
  • ubiquitin-conjugating enzyme E2N
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived;proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or;E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the;E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication;repair.
  • Synonyms
  • UBE2N; ubiquitin-conjugating enzyme E2N; ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) , ubiquitin conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-conjugating enzyme E2 N; MGC8489; UBC13; UbcH ben; yeast UBC13 homolog; ubiquitin-p
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2N, His-tagged
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UBE2N
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2N, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2N, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2N Protein, His-tagged, Active
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UBE2N Protein
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus UBE2N Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UBE2N Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UBE2N
Source (Host):Species:Human
Product nameRecombinant Human UBE2N 293 Cell Lysate

Involved Pathway

UBE2N involved in several pathways and played different roles in them. We selected most pathways UBE2N participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2N were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis

Protein Function

UBE2N has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2N itself. We selected most functions UBE2N had, and list some proteins which have the same functions with UBE2N. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein MYH13; ORC5; ORC4; PIP5K1C; NEK1; UBE2T; VWA8; RPS6KA2; TIE1; DGKE
Function poly(A) RNA binding
Related Protein MRPS26; DMGDH; DHX29; MRPS35; FAM46A; PRPF31; CRNKL1; RPS3; HIST2H4A; IFIT5
Function protein binding
Related Protein SEC22A; NOL6; TCTEX1D2; HARS2; AMHR2; VHL; WBP4; TAP2; KLRD1; ATG3
Function ubiquitin binding
Related Protein RNF31; VPS36; PER2; UBE2N; C36E6.2; NSFL1C; UBXN1; UBXN2B; UBXN11; TSG101
Function ubiquitin conjugating enzyme activity
Related Protein UBE2Z; UBE2Q2; UBE2C; UBE2D4; UBE2J2; UBE2T; UBE2E2; UBE2QL1; UBE2N; UBE2H
Function ubiquitin protein ligase activity
Related Protein CMTM2A; ASB4; UBE2NA; TRIM3; ZNRF2; RNF217; FBXO40; AMFR; UBR1; MSL2A
Function ubiquitin protein ligase binding
Related Protein GPI1; BRCA1; CLU; BAG5; UBE2C; DERL1; UBE2KA; CUL5; TCP1; AXIN2
Function ubiquitin-protein transferase activity
Related Protein UBE2N; SMURF1; UBE2T; BIRC5A; BIRC3; TRIM27; RNF139; UBE2E2; RNF187; RNF10

Interacting Protein

UBE2N has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2N here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2N.