ubr1
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  • Official Full Name
  • ubiquitin protein ligase E3 component n-recognin 1
  • Background
  • The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
  • Synonyms
  • UBR1; ubiquitin protein ligase E3 component n-recognin 1; JBS; E3 ubiquitin-protein ligase UBR1; E3a ligase; N-recognin-1; ubiquitin ligase E3 alpha-I; ubiquitin-protein ligase E3-alpha; ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein ligase E3-alpha-I;
Cat.#:UBR1-17760MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBR1 Protein
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Involved Pathway

UBR1 involved in several pathways and played different roles in them. We selected most pathways UBR1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
KIF11; CYBA; CDKN1B; GM11711; RNF144B; KLB; CD300LH; B2ML; KIF2A; FAM49BA
Antigen processing: Ubiquitination &
ATG7; UBE2U; UBE2E3; UBA5; HUWE1; RBCK1; RNF4; UBE2L6; PJA1; RNF123
Proteasome degradation
ASB11; UFL1; RNF4; TRIM41; CMTM2A; UBR2; DZIP3; LRSAM1; LRRC41; RNF25
Class I MHC mediated antigen processing &
TPP2; ASB4; RNF41; LRSAM1; TRIM69; ASB11; ASB10; ERAP1; RNF19B; RNF4
presentation
LTN1; KLHL20; RNF34; ASB10; CTSS; TRIM39; CD207; TRIM63; UBE2V1; UBE2V2
Immune System
BTR06; IRF9; IRF4; HLA-DQB2; ABI2; CTSD; FBXO3; TRIM38; SIGLEC9; BTR30

Protein Function

UBR1 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR1 itself. We selected most functions UBR1 had, and list some proteins which have the same functions with UBR1. You can find most of the proteins on our site.
Function
Related Protein
Function UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
Related Protein RC3H2; TRIM50; MARCH6; UBR1; TMEM129; MARCH4; MYLIPA; RNF149; ITCHA; TRIM71
Function coenzyme F420-0 gamma-glutamyl ligase activity
Related Protein SHRPRBCK1R; RNF187; ARIH1L; NEURL3; LTN1; RC3H2; TMEM129; MUL1A; MYLIPA; TRIM50
Function coenzyme F420-2 alpha-glutamyl ligase activity
Related Protein RFWD2; RNF187; MARCH9; ITCHA; SIAH2L; UBR1; RNF144AB; NEURL3; RAG1; MARCH4
Function leucine binding
Related Protein UBR1; GLUD2; UBR2; GLUD1
Function ligase activity
Related Protein TRIM6; HERC6; CBLC; RFWD2; RNF126; MYLIP; BIRC3; MUL1; RNF187; PET112L
Function metal ion binding
Related Protein MGRN1A; DAGLB; ARSE; SMAD7; CMC1; MMP1A; CNDP1; CYP2D9; FOXP2; ALKBH5
Function protein binding
Related Protein KCNQ4; PSMB4; GTF2E2; CCL5; SERINC1; MAPT; C16orf70; HIST1H4E; DNAJA2; NKD1
Function protein-glutamic acid ligase activity
Related Protein SIAH2L; MARCH11; NEURL3; HECW2; RNF149; RAG1; RNF187; NEURL1B; DTX1; RNF180
Function protein-glycine ligase activity
Related Protein ITCHA; UBE2IB; DTX1; HERC2; TRIM71; RNF149; UBR1; RNF169; TRIM50; RNF144AB
Function protein-glycine ligase activity, elongating
Related Protein ZNRF3; RFWD2; MYLIPB; ZNRF2B; RAG1; HERC2; LTN1; RC3H2; UBE2IB; TRIM71
Function protein-glycine ligase activity, initiating
Related Protein MYLIPA; SIAH2L; RNF169; MARCH6; TRIM41; MYLIPB; RFWD2; G2E3; ITCHA; RC3H2
Function ribosomal S6-glutamic acid ligase activity
Related Protein MYLIPA; MGRN1A; MARCH11; ITCHA; NEURL1B; MARCH5L; UBE2M; RAG1; RNF144AA; LTN1
Function tubulin-glutamic acid ligase activity
Related Protein MARCH9; NEURL3; ARIH1L; RNF169; SHRPRBCK1R; TMEM129; TRIM50; TRIM41; UBE2IB; MARCH5L
Function tubulin-glycine ligase activity
Related Protein RFWD2; ARIH1L; MARCH4; MARCH6; HECW2; ITCHA; DTX1; RNF149; G2E3; RNF144AB
Function ubiquitin protein ligase activity
Related Protein ZNRF1; HECTD3; RNF144B; UBE2B; ARIH2; RNF126; PJA2; UBE2N; MED10; MED17
Function ubiquitin-protein transferase activity
Related Protein G2E3; UBA7; RNF10; UBE2D1; KLHL20; FBXL6; TRAF4B; BIRC7; CBLB; UHRF1
Function zinc ion binding
Related Protein PRKCBP1L; PGLYRP6; DNAJC24; PHF20L1; ZNF2; USP39; MYRIP; TGFB1I1; MSRB1; RNF11B

Interacting Protein

UBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR1.
Sos1; Trpm7

UBR1 Related Articles

Scazzari, M; Amm, I; et al. Quality Control of a Cytoplasmic Protein Complex CHAPERONE MOTORS AND THE UBIQUITIN-PROTEASOME SYSTEM GOVERN THE FATE OF ORPHAN FATTY ACID SYNTHASE SUBUNIT Fas2 OF YEAST. JOURNAL OF BIOLOGICAL CHEMISTRY 290:4677-4687(2015).
Kawai, K; Moriya, A; et al. Functional Implications and Ubiquitin-Dependent Degradation of the Peptide Transporter Ptr2 in Saccharomyces cerevisiae. EUKARYOTIC CELL 13:1380-1392(2014).