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UBR1

Official Full Name

ubiquitin protein ligase E3 component n-recognin 1
Overview

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Synonyms

UBR1; ubiquitin protein ligase E3 component n-recognin 1; JBS; E3 ubiquitin-protein ligase UBR1; E3a ligase; N-recognin-1; ubiquitin ligase E3 alpha-I; ubiquitin-protein ligase E3-alpha; ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein ligase E3-alpha-I;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	UBR1-08H	Recombinant Human UBR1 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	UBR1-17760M	Recombinant Mouse UBR1 Protein	Mammalian Cell	His	Inquiry
Mouse	UBR1-9859M-B	Recombinant Mouse UBR1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	UBR1-9859M	Recombinant Mouse UBR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
UBR1 Related Articles

UBR1 involved in several pathways and played different roles in them. We selected most pathways UBR1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	CREB1B;KIF4A;IGLC2;KLRB1A;DCTN3;FRS2A;CTSE;RASGRP2;DNM1
Antigen processing: Ubiquitination &amp	NPEPPS;UBE2E3;SPSB4;DZIP3;STUB1;ASB7;SPSB2;UBR1;PJA2
Proteasome degradation	UCHL3;LRR1;TRIM63;CMTM2A;RNF144B;TRAF7;ASB9;UBE2V1;LTN1
Class I MHC mediated antigen processing &amp	TRIM11;UBE2V1;CMTM2A;ATG7;ASB3;UBR2;SH3RF1;WWP1;ASB18
presentation	ASB17;RNF6;UBE2E3;ATG7;CTSS;TRIM69;UBA5;ASB7;FBXO44
Immune System	RNF25;BFB;TNRC5;DEFB125;TLR10;CD160;ARIH2;ASB4;GBP4

UBR1 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR1 itself. We selected most functions UBR1 had, and list some proteins which have the same functions with UBR1. You can find most of the proteins on our site.

Function	Related Protein
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	TRIM71;MARCH9;TMEM129;HECW2;G2E3;SIAH2L;UBR1;MARCH4;MARCH5L
coenzyme F420-0 gamma-glutamyl ligase activity	MARCH4;NEURL3;UBE2IA;MARCH6;RNF180;ARIH1L;HECW2;RNF149;RNF187
coenzyme F420-2 alpha-glutamyl ligase activity	MGRN1A;UBE2IB;RNF149;UBE2IA;MUL1A;RNF144AB;DTX1;ITCHA;TRIM50
leucine binding	UBR2;UBR1;GLUD1;GLUD2
ligase activity	HERC4;TRIM63;MYLIP;UBE2NB;PELI1;MSL2;DTX1;MIB2;CBLL1
metal ion binding	NQO2;GNAZ;SH3RF3;ROCK2;GUCA1B;XIRP2;ZNF225;ADAM25;ZNF507
protein binding	SV2B;TANK;CCP110;SLAMF7;ZNF259;FBXO4;HP1BP3;HSPA13;FAM46C
protein-glutamic acid ligase activity	MYLIPA;RNF180;RC3H2;DTX1;MARCH6;RNF144AA;RFWD2;RNF149;MARCH11
protein-glycine ligase activity	UBE2IA;MUL1A;MARCH9;MYLIPB;MARCH5L;SHRPRBCK1R;G2E3;UBR1;ZNRF3
protein-glycine ligase activity, elongating	MARCH6;DTX1;MUL1A;ITCHA;MARCH5L;MYLIPB;TRIM41;HECW2;RNF144AA
protein-glycine ligase activity, initiating	RNF169;RNF144AB;MARCH9;ZNRF2B;UBR1;RAG1;UBE2IA;TTLL3;MARCH6
ribosomal S6-glutamic acid ligase activity	TMEM129;RNF169;ITCHA;MARCH4;DTX1;MGRN1A;RNF180;RFWD2;G2E3
tubulin-glutamic acid ligase activity	HERC2;TRIM50;RNF187;TTLL1;SIAH1A;MYLIPB;RNF144AA;UBR1;TRIM41
tubulin-glycine ligase activity	SIAH1A;MARCH6;RFWD2;MGRN1A;TRIM41;RNF144AB;ARIH1L;MUL1A;RNF187
ubiquitin protein ligase activity	UBE2R2;CDC34;HECW1;RNF181;TRIM2;PDZRN3B;SMURF1;RNF146;PDZRN4
ubiquitin-protein transferase activity	HACE1;MUL1B;RLIM;UBE2D2A;HECW2;ANAPC4;PRKCQ;LMO7;TRIM68
zinc ion binding	ZNF276;JADE3;ATRX;LIG3;SRSF7;PHF10;KAT6B;SETDB2;LNPEP

UBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR1.

Sos1; Trpm7

Scazzari, M; Amm, I; et al. Quality Control of a Cytoplasmic Protein Complex CHAPERONE MOTORS AND THE UBIQUITIN-PROTEASOME SYSTEM GOVERN THE FATE OF ORPHAN FATTY ACID SYNTHASE SUBUNIT Fas2 OF YEAST. JOURNAL OF BIOLOGICAL CHEMISTRY 290:4677-4687(2015).

Kawai, K; Moriya, A; et al. Functional Implications and Ubiquitin-Dependent Degradation of the Peptide Transporter Ptr2 in Saccharomyces cerevisiae. EUKARYOTIC CELL 13:1380-1392(2014).