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UBR5

Official Full Name

ubiquitin protein ligase E3 component n-recognin 5
Overview

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
Synonyms

UBR5; ubiquitin protein ligase E3 component n-recognin 5; E3 ubiquitin protein ligase, HECT domain containing, 1 , EDD1; E3 ubiquitin-protein ligase UBR5; DD5; EDD; HYD; KIAA0896; hHYD; ubiquitin-protein ligase; progestin induced protein; progestin-induce;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UBR5-4053H	Recombinant Human UBR5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Zebrafish	UBR5-7576Z	Recombinant Zebrafish UBR5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UBR5 Related Articles

UBR5 involved in several pathways and played different roles in them. We selected most pathways UBR5 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquitin mediated proteolysis	MGRN1B;NEDD4L;SOCS1;MGRN1;UBA6;MID1;UBE2IA;CBL;UBE2D2

UBR5 has several biochemical functions, for example, RNA binding, ligase activity, ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR5 itself. We selected most functions UBR5 had, and list some proteins which have the same functions with UBR5. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	SAMD4;EIF4B;CELF3A;SCAF8;PUS7L;TTC6;EIF1AXA;SFSWAP;LRPPRC
ligase activity	SH3RF2;MARCH11;RBCK1;MGRN1A;UCHL1;RNF170;UBE2NA;CBL;MYLIPB
ubiquitin binding	UCHL3;USP25;HSPB1;OTUB1B;FAN1;C36E6.2;CRY2;UBR5;NBR1
ubiquitin protein ligase activity	RNF144AA;UBE2N;UBE2U;RNF34;CDC42;LTN1;C12orf51;RNF115;RNF165
ubiquitin-protein transferase activity	TNFAIP3;FBXW2;UBE2L6;LNX1;WWP2;UBE2D3;TOPORS;HECW1B;TRIM71
zinc ion binding	ZCCHC2;RPH3A;SNRPC;RNF139;ADAMTS15;FHL2;ZCRB1;FTR54;SUV39H2

UBR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR5.

Wu, C; Chen, ZJ; et al. DUBA-UBR5 axis: other than transactivation. CELL RESEARCH 25:273-274(2015).

Rutz, S; Kayagaki, N; et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. NATURE 518:-(2015).