Human UBR5 Knockdown Cell Lysate

• Cat.No.: UBR5-463HKCL
• Product Overview: WB-validated UBR5 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 309 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg UBR5 KD HeLa cell lysate
• Protein Families: Druggable Genome
• Protein Pathways: Ubiquitin mediated proteolysis
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: UBR5 ubiquitin protein ligase E3 component n-recognin 5 [ Homo sapiens (human) ]
• Official Symbol: UBR5
• Synonyms: UBR5; ubiquitin protein ligase E3 component n-recognin 5; E3 ubiquitin protein ligase, HECT domain containing, 1, EDD1; E3 ubiquitin-protein ligase UBR5; DD5; EDD; HYD; KIAA0896; hHYD; ubiquitin-protein ligase; progestin induced protein; progestin-induced protein; hyperplastic discs protein homolog; E3 identified by differential display; E3 ubiquitin-protein ligase, HECT domain-containing 1; E3 ubiquitin protein ligase, HECT domain containing, 1; EDD1; FLJ11310; MGC57263
• Gene ID: 51366
• mRNA Refseq: NM_015902
• Protein Refseq: NP_056986
• MIM: 608413
• UniProt ID: O95071