ugt1a7
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  • Official Full Name
  • UDP glucuronosyltransferase 1 family, polypeptide A7
  • Background
  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
  • Synonyms
  • UGT1A7; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-7; UGT1G; GNT1; OTTHUMP00000065199; UD17_HUMAN; UDP glucuronosyltransferase 1A7; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A7; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1A7; UDPGT; UDPGT 1-7; UGT-1G; UGT1; UGT1*7; UGT1-07; UGT1.7; UDP glycosyltransferase 1 family, polypeptide A7
Cat.#:UGT1A7-982HTag:N/A
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human UGT1A7 protein
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Cat.#:UGT1A7-31664THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human UGT1A7
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Cat.#:UGT1A7-7715ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UGT1A7
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Involved Pathway

UGT1A7 involved in several pathways and played different roles in them. We selected most pathways UGT1A7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
Akr1b3; UGT2A2; UGT2B7; ALDH2; UGT2A1; ALDH1B1; OXSR1; UGT1A3; SORD; UGT1A7C
Ascorbate and aldarate metabolism
UGT1AB; ALDH1B1; GKUP; ALDH9A1; ALDH9A1A.1; ALDH2.2; ALDH3A2; UGT2B15; UGT2A3; UGT1A6B
Steroid hormone biosynthesis
HSD11B1; HSD17B12B; CYP11C1; UGT2B7; STS; CYP2C55; UGT1A7C; CYP2B19; CYP2C70; SRD5A2
Starch and sucrose metabolism
UGT2B7; PYGM; PGM1; UXS1; GUSB; UGT1A7C; GAA; UGP2; AMY2A2; UGP2B
Retinol metabolism
UGT1A1; Aldh1a7; UGT1A2; RDH8A; UGT1A6; UGT1AB; CYP2B19; UGT1A6B; SDR16C5A; CYP3A41A
Porphyrin and chlorophyll metabolism
HEPH; EARS2; PPOX; HCCSA.1; HMBSB; ALAS2; BLVRA; COX15; GUSB; HMBSA
Metabolism of xenobiotics by cytochrome P
GSTM6; HSD11B1; GSTA3; UGT1A1; UGT1A4; UGT2B15; AKR7A5; AKR7A2; GSTP2; ALDH3B1
Drug metabolism - cytochrome P
AOX3; UGT1A1; GSTO1; FMO6P; FMO3; GSTM3; MGST1; ALDH3B2; ALDH3B1; GSTA4
Drug metabolism - other enzymes
UGT2B15; IMPDH1; CES1C; Ces2c; UPP2; UPP1; TPMT.1; DPYDB; TK2; UGT1A2
Metabolic pathways
TGDS; POLR3G; ADK; PLCD1B; NDST4; PIGX; RDH11; PLCE1; CYP21A1; MOGS
Chemical carcinogenesis
GSTM1; CYP2B19; UGT1A9; CYP2C18; CYP3A41A; EPHX1; SULT1A2; GSTA2; ADH4; GSTP1

Protein Function

UGT1A7 has several biochemical functions, for example, drug binding, enzyme binding, enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A7 itself. We selected most functions UGT1A7 had, and list some proteins which have the same functions with UGT1A7. You can find most of the proteins on our site.
Function
Related Protein
Function drug binding
Related Protein DHODH; CHRM1; MTOR; SRP54A; CHRNA3; PPARG; CYP4B1; HTR2B; GABRA1; FOLR2
Function enzyme binding
Related Protein ATXN10; BCR; EIF2AK3; CREB1; HMGA1-RS1; CABYR; NOTCH3; CDC20; GSTM2; Il6ra
Function enzyme inhibitor activity
Related Protein KIAA1967; PLN; SLN; SCG5; HSPBP1; ARRB1; ANGPTL4; WDTC1; ATPIF1B; OAZ2B
Function glucuronosyltransferase activity
Related Protein UGT2B6; UGT2A6; UGT2A1; UGT2A3; CSGALNACT1; UGT2B7; B3GNT1; UGT5D1; UGT2B5; UGT1A5
Function NOT glucuronosyltransferase activity
Related Protein UGT1A3; UGT1A7; UGT1A4; UGT1A6; UGT1A1; UGT1A9
Function protein heterodimerization activity
Related Protein SYT5; SYT14; POLE4; CD3D; BCL2A1; SEPHS1; FLOT1; MID1; ITGB1; NPM1
Function protein homodimerization activity
Related Protein THRA; ZHX3; HMGCL; DAXX; MTUS2; CAMK2A; NTRK2; NR6A1; HLA-G; ZFP652
Function protein kinase C binding
Related Protein TRPV4; DACT2; SDPRB; DACT1; SDPR; PARD6A; FEZ1; GLRX3; TOP2B; PKP2
Function retinoic acid binding
Related Protein UGT1A3; CRABP1B; CRABP1; CRABP2; UGT1A1; LCN12; UGT1A2; CRABP1A; NR2F2; CRABP2B

Interacting Protein

UGT1A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A7.
pkcepsilon_chlae_protein; PRKCE; epsilon-rack_chlae_protein

UGT1A7 Related Articles

Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).
Joy, MS; Boyette, T; et al. Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 66:1119-1130(2010).