||This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
|Tissue specificity :
||Liver and gastric tissue.
|Biological activity :
||Vial Content: 5 mg protein.concentration 2-20 mg/mL protein
|Storage buffer :
||Preservative: NoneConstituents: 20% Glycerol, 100mM Potassium phosphate, 1mM DTT, 0.1mM EDTA, pH 7.4
||Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
|Sequences of amino acids :
||MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFT MQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTS YTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKY FSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDA MTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQG KPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIA DALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKR METKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRL SSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGR VKKAHKSKTH
|Sequence Similarities :
||Belongs to the UDP-glycosyltransferase family.