ugt1a9
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  • Official Full Name
  • UDP glucuronosyltransferase 1 family, polypeptide A9
  • Background
  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.
  • Synonyms
  • UGT1A9; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; HLUGP4; LUGP4; UGT1AI; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UGT1I; UGT-1I
Cat.#:UGT1A9-12HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human UGT1A9, GST-tagged
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Cat.#:UGT1A9-179HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UGT1A9 Protein, GST/His-tagged
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Cat.#:UGT1A9-3587HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UGT1A9, GST-tagged
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Cat.#:UGT1A9-17811MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UGT1A9 Protein
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Cat.#:UGT1A9-1078CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus UGT1A9 Protein, His-tagged
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Cat.#:UGT1A9-510HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UGT1A9 293 Cell Lysate
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Involved Pathway

UGT1A9 involved in several pathways and played different roles in them. We selected most pathways UGT1A9 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
DCXR; UGP2A; ALDH2; UGT1A9; AKR1A1A; KL; AKR1B7; UGT1A2; AKR1B1L; ALDH1B1
Ascorbate and aldarate metabolism
UGDH; UGT2A1; ALDH9A1B; UGT1A9; UGT2B15; ALDH2; UGT2B7; ALDH2.1; ALDH2.2; UGT1A1
Steroid hormone biosynthesis
CYP2C45; CYP3A25; CYP7B1; UGT1A7; HSD3B2; HSD3B1; UGT1A7C; CYP2C70; HSD17B12A; UGT1A3
Starch and sucrose metabolism
AMY1A; UGT1A7; UGP2B; ENPP3; Amy1; PYGM; UGT1A4; AMY1B; UGT1A3; UGT1A1
Retinol metabolism
UGT1A2; UGT2B7; CYP2C45; RETSAT; CYP4A12A; ALDH1A2; CYP2C54; RDH8A; CYP2C50; RDH11
Porphyrin and chlorophyll metabolism
GUSB; UGT2A3; ALAD; UGT1A7C; CPOX; MMAB; UGT1AB; HMBSB; UGT1A6A; HCCSB
Metabolism of xenobiotics by cytochrome P
MGST1.1; GSTT1; UGT1A9; UGT1A6B; GSTT2; AKR7A3; GSTO1; UGT5G1; UGT1A4; UGT1AB
Drug metabolism - cytochrome P
AOX3; FMO1; UGT2A3; MGST1; FMO3; GSTT2B; UGT1A3; GSTA4; UGT1A6A; GSTM7
Drug metabolism - other enzymes
UGT2B7; GMPS; UGT1A1; TPMT.1; CES1D; UGT1A7C; TYMP; UGT1A9; UGT5G1; DPYD
Metabolic pathways
CYP7A1; PSPH; AK2; GLULB; GLUD2; ATP6V1AA; DCTPP1; UGT1A2; PTGES3A; Ckmm
Chemical carcinogenesis
CYP2C70; CHRNA7; CCBL1; CYP2C50; SULT1A1; ADH5; GSTM5; CYP2C55; SULT2A1; GSTT2

Protein Function

UGT1A9 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A9 itself. We selected most functions UGT1A9 had, and list some proteins which have the same functions with UGT1A9. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein HMGA1-RS1; APP; TRP53; RPS3; HMGA1; BRCA1; KPNB1; ITGB3; RCOR3; ADORA2A
Function enzyme inhibitor activity
Related Protein HSPBP1; OAZ2A; SLN; ATPIF1B; WFIKKN1; SCG5; TXNIP; TAE1; UGT1A1; KIAA1967
Function glucuronosyltransferase activity
Related Protein UGT1B7; GYLTL1B; UGT1A6B; UGT1A6; UGT5F1; UGT1A9; UGT1B1; UGT8; UGT5A3; LARGE
Function NOT glucuronosyltransferase activity
Related Protein UGT1A4; UGT1A9; UGT1A1; UGT1A7; UGT1A6; UGT1A3
Function protein heterodimerization activity
Related Protein BMP2B; FZD9; ERBB3; HIST1H3G; ADRA2A; BCL11A; ADRB1; HIST2H2L; TYRP1; MAP3K7
Function protein homodimerization activity
Related Protein ODZ4; ACAT1; LRRFIP1; ERCC5; ASMT; IL6ST; HEXB; PDCD6IP; MID1; NADK2
Function retinoic acid binding
Related Protein UGT1A3; UGT1A7; PTGDSB; UGT1A9; CRABP1B; CRABP2A; CYP26A1; CRABP2B; NR2F2; CRABP1A

UGT1A9 Related Articles

Zhang, HB; Patana, AS; et al. Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics. DRUG METABOLISM AND DISPOSITION 40:1935-1944(2012).
Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).