UHRF2 Protein, ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase


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Official Full Name ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Background This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.
Synonyms UHRF2; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin like with PHD and ring finger domains 2; E3 ubiquitin-protein ligase UHRF2; MGC33463; NIRF; Np95 like ring finger protein; RNF107; URF2; nuclear protein 97; R
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UHRF2-10H Recombinant Human UHRF2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human UHRF2-507HCL Recombinant Human UHRF2 293 Cell Lysate HEK293 N/A
    Mouse UHRF2-17829M Recombinant Mouse UHRF2 Protein Mammalian Cell His

    UHRF2 involved in several pathways and played different roles in them. We selected most pathways UHRF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UHRF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    UHRF2 has several biochemical functions, for example, DNA binding, histone binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UHRF2 itself. We selected most functions UHRF2 had, and list some proteins which have the same functions with UHRF2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding GTF2E2; ISX; BARX2; BHLHE41; CHD1; POLR2C; ZNF705A; ZNF791; MYO18A; NKX2.7
    histone binding PKN1; NPM2; ATRX; NCAPD3; APBB1; HIST1H3C; TBL1XR1; HIST1H47; NAP1L2; CD1d1
    ligase activity TRIM8; CPS1; RNF115; TRIM68; UBE2L3B; TTLL5; DTX3; SH3RF2; RNF170; MYLIPA
    protein binding NUP54; OFD1; C7orf53; HMGN2; SEPT1; MAPK10; F2R; FAM81B; PEX26; COG1
    ubiquitin protein ligase activity UBE2KA; RNF34; COP1; FBXO6; RNF175; TRAF6; TRIP12; RNF121; FBXO30; UBE2S
    ubiquitin-protein transferase activity DTX3L; BARD1; RNF115; FBXO7; UBE2N; MARCH5; MARCH8; MUL1; CNOT4; RNF144B
    zinc ion binding UNKL; EWSR1A; AGBL2; PPARAB; LHX1B; FBXO11A; APOBEC1; LIMA1; TRIM54; ZCCHC7

    UHRF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UHRF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UHRF2.

    CDK2; CCND1; CCNE1; RB1; TP53

    Zhou, T; Xiong, J; et al. Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. MOLECULAR CELL 54:879-886(2014).
    Lu, S; Yan, DW; et al. Ubiquitin-like with PHD and ring finger domains 2 is a predictor of survival and a potential therapeutic target in colon cancer. ONCOLOGY REPORTS 31:1802-1810(2014).

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