Recombinant Human UHRF2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: UHRF2-1103H
• Product Overview: UHRF2 MS Standard C13 and N15-labeled recombinant protein (NP_690856) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 89.8 kDa
• AA Sequence: MWIQVRTIDGSKTCTIEDVSRKATI EELRERVWALFDVRPECQRLFYRGK QLENGYTLFDYDVGLNDIIQLLVRP DPDHLPGTSTQIEAKPCSNSPPKVK KAPRVGPSNQPSTSARARLIDPGFG IYKVNELVDARDVGLGAWFEAHIHS VTRASDGQSRGKTPLKNGSSCKRTN GNIKHKSKENTNKLDSVPSTSNSDC VAADEDVIYHIQYDEYPESGTLEMN VKDLRPRARTILKWNELNVGDVVMV NYNVESPGQRGFWFDAEITTLKTIS RTKKELRVKIFLGGSEGTLNDCKII SVDEIFKIERPGAHPLSFADGKFLR RNDPECDLCGGDPEKKCHSCSCRVC GGKHEPNMQLLCDECNVAYHIYCLN PPLDKVPEEEYWYCPSCKTDSSEVV KAGERLKMSKKKAKMPSASTESRRD WGRGMACVGRTRECTIVPSNHYGPI PGIPVGSTWRFRVQVSEAGVHRPHV GGIHGRSNDGAYSLVLAGGFADEVD RGDEFTYTGSGGKNLAGNKRIGAPS ADQTLTNMNRALALNCDAPLDDKIG AESRNWRAGKPVRVIRSFKGRKISK YAPEEGNRYDGIYKVVKYWPEISSS HGFLVWRYLLRRDDVEPAPWTSEGI ERSRRLCLRLQYPAGYPSDKEGKKP KGQSKKQPSGTTKRPISDDDCPSAS KVYKASDSAEAIEAFQLTPQQQHLI REDCQNQKLWDEVLSHLVEGPNFLK KLEQSFMCVCCQELVYQPVTTECFH NVCKDCLQRSFKAQVFSCPACRHDL GQNYIMIPNEILQTLLDLFFPGYSK GRTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: UHRF2 ubiquitin like with PHD and ring finger domains 2 [ Homo sapiens (human) ]
• Official Symbol: UHRF2
• Synonyms: UHRF2; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin like with PHD and ring finger domains 2; E3 ubiquitin-protein ligase UHRF2; MGC33463; NIRF; Np95 like ring finger protein; RNF107; URF2; nuclear protein 97; RING finger protein 107; Np95-like ring finger protein; nuclear zinc finger protein NP97; np95/ICBP90-like RING finger protein; ubiquitin-like, containing PHD and RING finger domains, 2; ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like-containing PHD and RING finger domains protein 2; RP11-472F14.2; DKFZp434B0920; DKFZp686G0837
• Gene ID: 115426
• mRNA Refseq: NM_152896
• Protein Refseq: NP_690856
• MIM: 615211
• UniProt ID: Q96PU4