upf3b
Share
  • Official Full Name
  • UPF3 regulator of nonsense transcripts homolog B (yeast)
  • Background
  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast); MRX62; UPF3X; HUPF3B; MRXS14; RENT3B; regulator of nonsense transcripts 3B; hUpf3p-X; mental retardation, X-linked 62; nonsense mRNA reducing factor 3B; up-frameshift suppressor 3 homolog B; up-frameshift suppressor 3 homolog on chromosome X;
Cat.#:UPF3B-631HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human UPF3B Protein, MYC/DDK-tagged
+Inquiry
Cat.#:UPF3B-31673THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UPF3B, His-tagged
+Inquiry
Cat.#:UPF3B-5108RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UPF3B Protein, His-tagged
+Inquiry
Cat.#:UPF3B-11191ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UPF3B
+Inquiry

Involved Pathway

UPF3B involved in several pathways and played different roles in them. We selected most pathways UPF3B participated on our site, such as RNA transport, mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UPF3B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RNA transport
RPP25; RANBP2; CASC3; POP4; CYFIP2; EIF3G; BAT1; EIF3E; PEAK1; EIF2S3Y
mRNA surveillance pathway
PPP2R3C; ETF1; PPP1CC; PABPC3; MSI2A; PPP2R2CA; CPSF2; PPP2R2D; CPSF6; PPP2R5C

Protein Function

UPF3B has several biochemical functions, for example, actin binding, calmodulin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UPF3B itself. We selected most functions UPF3B had, and list some proteins which have the same functions with UPF3B. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein MYO1C; DIXDC1; SLC4A1; PARVB; ABLIM1B; GIPC1; FKBP15; BAIAP2L1; MYH9; MYO1F
Function calmodulin binding
Related Protein MYO1C; CALD1B; RGS2; KCNH5; AKAP5; CAMK2G; EWSR1; RGS16; MKNK2A; MYH9
Function protein binding
Related Protein ESYT2; MZB1; TAGLN2; PTK6; IFT46; UBA5; AKR1B10; MED21; CNBP; GLIS2

Interacting Protein

UPF3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPF3B here. Most of them are supplied by our site. Hope this information will be useful for your research of UPF3B.
RBM8A; UPF2; EIF4A3

UPF3B Related Articles

Tarpey, PS; Raymond, FL; et al. Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. NATURE GENETICS 39:1127-1133(2007).