USP18 Protein, ubiquitin specific peptidase 18


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Official Full Name ubiquitin specific peptidase 18
Background Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD and JAMM enzymes (1,2). USP18 (also known as UBP43
Synonyms USP18; ubiquitin specific peptidase 18; ubiquitin specific protease 18; ubl carboxyl-terminal hydrolase 18; hUBP43; ubl thioesterase 18; ubl thiolesterase 18; 43 kDa ISG15-specific protease; ISG15-specific-processing protease; ISG43; UBP43
    • Species :
    • Human
    • Source :
    • HEK293
    • Insect Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human Usp18-32M Recombinant Mouse Usp18 Protein, His-tagged Insect cell His
    Human USP18-149H Recombinant Human USP18, His-tagged Insect Cell His
    Human USP18-469HCL Recombinant Human USP18 293 Cell Lysate HEK293 N/A

    USP18 involved in several pathways and played different roles in them. We selected most pathways USP18 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antiviral mechanism by IFN-stimulated genes DPF1; NUPL2; NUP50; JAK1; KPNA5; EIF4E; IFIT14; EIF4G2A; IFIT10; KPNA4
    Cytokine Signaling in Immune system IFI35; NUP50; CSHL1; MX2; EIF4G1; IRF6; PEA15; DPF1; BST2; TRIM5
    ISG15 antiviral mechanism EIF4G2A; IFIT8; HERC5; USP18; EIF4E3; ARIH1; EIF4G2; UBE2L6; IFIT11; IFIT14
    Immune System DEFB104A; ASB4; AGER; C1rb; DEFB1; CYBB; CRCP; CRP; KLRB1F; TXNIPB
    Interferon Signaling BST2; IRF4; EIF4E3; ADAR; IFI35; IFIT14; TRIM6; TRIM10; TRIM2; IFIT12
    Interferon alpha/beta signaling IFI27; BST2; IRF6; IRF9; MX2; ISG20; OASL; IFIT2; SAMHD1; XAF1
    Regulation of IFNA signaling USP18

    USP18 has several biochemical functions, for example, ISG15-specific protease activity, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP18 itself. We selected most functions USP18 had, and list some proteins which have the same functions with USP18. You can find most of the proteins on our site.

    Function Related Protein
    ISG15-specific protease activity USP18
    cysteine-type endopeptidase activity USP45; USP20; CTSJ; CASP6; CTSSB.2; USP49; CTSF; CASP8L1; USP3; CASPA
    protein binding GLS2; GABARAPL1; CDK2AP1; RBMY1A1; DNMT3A; ISCU; RAD23B; UBXN1; ZNF165; CEP85
    ubiquitin-specific protease activity USP14; USP30; OTUD5A; FAM105B; DUB1; EIF3F; CYLD; FMNL3; USP31; BRCC3

    USP18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP18 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP18.

    ISG15; b4dyc6_human; SGTA; NME1; STIP1; IFNAR2; MLF1; MYL6; FKBP5; USP41; HSP90AB1; KDM3B; NUDCD3; q96be0_human

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