usp18
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  • Official Full Name
  • ubiquitin specific peptidase 18
  • Background
  • Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD and JAMM enzymes (1,2). USP18 (also known as UBP43
  • Synonyms
  • USP18; ubiquitin specific peptidase 18; ubiquitin specific protease 18; ubl carboxyl-terminal hydrolase 18; hUBP43; ubl thioesterase 18; ubl thiolesterase 18; 43 kDa ISG15-specific protease; ISG15-specific-processing protease; ISG43; UBP43
Cat.#:Usp18-32MTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Mouse Usp18 Protein, His-tagged
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Cat.#:USP18-149HTag:His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human USP18, His-tagged
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Cat.#:USP18-469HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human USP18 293 Cell Lysate
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Involved Pathway

USP18 involved in several pathways and played different roles in them. We selected most pathways USP18 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antiviral mechanism by IFN-stimulated genes
ARIH1; EIF4E; NUP50; IFIT11; KPNA5; NUP35; ARIH1L; HERC5; KPNA4; EIF4A2
Cytokine Signaling in Immune system
PAQR3A; CRK; FGF18B; TRIM17; IFIT12; EIF4E3; TRIM62; PRLRB; PTPRA; NEFLB
ISG15 antiviral mechanism
IFIT11; ARIH1; KPNA4; IFIT14; KPNA5; EIF4G2A; USP18; KPNA3; IFIT8; EIF4E3
Immune System
DTX3L; USP18; CFD; MYO1C; KLRB1B; RNF182; BTR02; C1rb; CTSC; BTR09
Interferon Signaling
TRIM8; IRF6; IFIT14; TRIM31; EIF4G2; IFITM3; XAF1; USP18; IFIT2; TRIM22
Interferon alpha/beta signaling
IFI35; USP18; XAF1; IFIT3; IFI27; GBP2; MX2; IFIT2; ISG20; IRF4
Regulation of IFNA signaling
USP18

Protein Function

USP18 has several biochemical functions, for example, ISG15-specific protease activity, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP18 itself. We selected most functions USP18 had, and list some proteins which have the same functions with USP18. You can find most of the proteins on our site.
Function
Related Protein
Function ISG15-specific protease activity
Related Protein USP18
Function cysteine-type endopeptidase activity
Related Protein CASP9; USP27X; CTSW; USP44; CTSF; MALT1A; CASP2; CTSSB.2; USP2A; FAM49BA
Function protein binding
Related Protein ZC3HC1; STRAP; SEC22C; UQCC1; ACPL2; E2F8; INTS5; PCDHA4; TAGLN2; ZNF295
Function ubiquitin-specific protease activity
Related Protein USP43A; UCHL5; OTULIN; USP25; USP40; USP9X; USP4; USP45; USP33; UFD1L

Interacting Protein

USP18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP18 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP18.
ISG15; b4dyc6_human; SGTA; NME1; STIP1; IFNAR2; MLF1; MYL6; FKBP5; USP41; HSP90AB1; KDM3B; NUDCD3; q96be0_human