IL-10 Signaling Related Molecules
Available Resources for IL-10 Signaling Related Molecules Research
At Creative BioMart, we are thrilled to present our wide-ranging collection of products associated with IL-10 signaling related molecules. Our product portfolio includes high-quality recombinant proteins, protein pre-coupled magnetic beads, cell and tissue lysates, and more. These essential tools cater to the diverse needs of researchers, enabling them to conduct in-depth studies in their respective fields. With customizable services, we ensure that you find the perfect product tailored to your specific research requirements.
In addition to our comprehensive product offering, we are committed to providing a wealth of information on IL-10 signaling related molecules. Our resources cover a broad spectrum of topics, including pathways, protein function, interacting proteins, related articles, and research areas. These valuable resources serve as references for researchers aiming to augment their understanding of IL-10 signaling related molecules and their roles in various physiological processes. By offering an integration of products and knowledge, we actively support researchers in driving advancements within this research field.
Our Featured Products
| Cat.# | Product name | Species | Source (Host) | Tag |
|---|---|---|---|---|
| STAT1-2996H | Recombinant Human STAT1 protein, GST-tagged | Human | E.coli | GST |
| STAT2-2997H | Recombinant Human STAT2, GST-tagged | Human | E.coli | GST |
| STAT3-1496H | Recombinant Human STAT3, GST-tagged | Human | Sf9 Insect Cell | GST |
| TIGIT-107H | Active Recombinant Human TIGIT protein, Fc-tagged | Human | HEK293 | Fc |
| Tigit-108M | Active Recombinant Mouse Tigit, Fc-tagged | Mouse | Human Cell | Fc |
About IL-10 Signaling Related Molecules
IL-10 family receptors play a crucial role in immunomodulation by mediating the effects of IL-10 family ligands on immune cells and their responses. Here are the key roles of IL-10 family receptors in immunomodulation:
Transcription Factors
- STAT1 (Signal Transducer and Activator of Transcription 1): STAT1 is primarily associated with interferon (IFN) signaling pathways, including type I and type II IFN signaling. While STAT3 is the main transcription factor involved in IL-10 signaling, STAT1 can also be activated downstream of IL-10 in certain contexts. It plays a role in regulating immune responses and inflammation.
- STAT2 (Signal Transducer and Activator of Transcription 2): STAT2 is primarily involved in the signaling pathways of interferons, particularly type I IFNs. However, like STAT1, STAT2 can also be involved in IL-10 signaling, contributing to the modulation of immune responses.
Immune Checkpoint Molecules
- TIGIT (T cell Immunoreceptor with Ig and ITIM domains): TIGIT is a cell surface receptor expressed on various immune cells, including T cells and natural killer cells. It acts as an immune checkpoint molecule and plays a role in immune regulation. TIGIT interacts with its ligands, such as CD155, and can inhibit T cell activation and effector functions. IL-10 has been shown to enhance TIGIT expression on T cells, contributing to its immunosuppressive effects.
Deubiquitinating Enzymes
- USP15 (Ubiquitin Specific Peptidase 15): USP15 is a deubiquitinase enzyme that can remove ubiquitin moieties from target proteins, modulating their stability and signaling activities. USP15 has been found to interact with and stabilize the IL-10 receptor, thereby promoting IL-10 signaling and its downstream effects.
- USP18 (Ubiquitin Specific Peptidase 18): USP18 is another deubiquitinase enzyme that regulates signaling pathways. It is primarily involved in the negative regulation of type I IFN signaling by inhibiting the JAK/STAT pathway downstream of the IFN receptor. USP18 can also suppress IL-10 signaling, potentially influencing the balance between pro-inflammatory and anti-inflammatory responses.
Suppressor of Cytokine Signaling (SOCS) Proteins
- Suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine signaling pathways, including IL-10 signaling. Upon IL-10 stimulation, SOCS proteins, such as SOCS1 and SOCS3, are induced and act as feedback inhibitors to suppress IL-10 signaling. They accomplish this by binding to JAKs and inhibiting their kinase activity, thereby dampening the IL-10 signaling cascade.
These molecules, including the transcription factors STAT1, STAT2, STAT3, STAT4, and STAT6, immune checkpoint molecule TIGIT, and deubiquitinating enzymes USP15 and USP18, contribute to the complexity of IL-10 signaling and its immunomodulatory effects. They play important roles in regulating immune responses, inflammation, and maintaining immune homeostasis.
Role of IL-10 Signaling Related Molecules in Disease Development
IL-10 signaling and its related molecules play significant roles in the development and progression of various diseases. Here are some examples:
Inflammatory Diseases: Dysregulation of IL-10 and its signaling pathway can contribute to the development of chronic inflammatory diseases, such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and asthma. Decreased IL-10 production or impaired signaling can lead to excessive inflammation and tissue damage.
Autoimmune Diseases: Autoimmune diseases arise from an inappropriate immune response against self-antigens. IL-10 signaling molecules, particularly STAT3, play important roles in maintaining immune tolerance and preventing autoimmunity. Deficiencies in IL-10 or impaired STAT3 activation can disrupt immune regulation, leading to the development of autoimmune diseases like systemic lupus erythematosus (SLE) and multiple sclerosis (MS).
Cancer: In some cases, IL-10 and its downstream signaling molecules can promote tumor growth and immune evasion by suppressing anti-tumor immune responses. On the other hand, IL-10 can also exert anti-tumor effects by inhibiting pro-inflammatory cytokine production, promoting immune tolerance, and suppressing tumor-promoting inflammation. The balance between pro-tumor and anti-tumor effects of IL-10 signaling may vary depending on the specific tumor microenvironment and immune context.
Infectious Diseases: IL-10 can help control excessive inflammation and tissue damage during infections by suppressing pro-inflammatory cytokine production. However, pathogens can exploit IL-10 signaling to evade immune responses and promote their survival. For example, certain viruses and bacteria can induce IL-10 production or modulate IL-10 signaling to suppress immune defense mechanisms.
Neurological Disorders: IL-10 and its signaling molecules have been implicated in the pathogenesis of neurological disorders, including neuroinflammatory conditions like multiple sclerosis (MS) and neurodegenerative diseases like Alzheimer's disease (AD). Dysregulation of IL-10 signaling can contribute to neuroinflammation, immune cell infiltration into the central nervous system, and neuronal damage.
Understanding the roles of IL-10 signaling molecules in disease development is crucial for developing targeted therapies and interventions. Modulating IL-10 signaling may hold potential for therapeutic strategies aimed at controlling inflammation, restoring immune balance, and managing various diseases. However, the specific roles and effects of IL-10 signaling molecules can vary depending on the disease context, highlighting the complexity of their involvement in different pathological conditions.
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Related Reference:
- Walter MR. The molecular basis of IL-10 function: from receptor structure to the onset of signaling. Curr Top Microbiol Immunol. 2014;380:191-212. doi:10.1007/978-3-662-43492-5_9
