Active Recombinant Mouse Usp18 Protein, His-tagged
|Product Overview :||Recombinant mouse Usp18 protein (Ser47 - Ser368) contains an N-terminal 6-His tag was expressed in Spodoptera frugiperda, Sf 21 (baculovirus).|
- Gene Information
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|Description :||Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.|
|Source :||Insect cell|
|Bio-activity :||Reaction conditions will need to be optimized for each specific application. We recommend an initial recombinant murine USP18 concentration of 100-250 nM when using ISG15-AMC as a substrate.|
|Molecular Mass :||38 kDa|
|Purity :||>98%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.|
|Storage :||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
24 months from date of receipt, -70 centigrade as supplied.
3 months, -70 centigrade under sterile conditions after opening.
|Storage Buffer :||X mg/mL (X μM) in 50 mM HEPES pH 7.5, 200 mM NaCl, 10% (v/v) Glycerol, 5 mM DTT and 1 mM EDTA|
|Gene Name :||Usp18 ubiquitin specific peptidase 18 [ Mus musculus (house mouse) ]|
|Official Symbol :||Usp18|
|Synonyms :||43 kDa ISG15-specific protease; ISG15-specific-processing protease; ubiquitin specific protease 15; ubiquitin specific protease 18; ubl thioesterase 18; ubl thiolesterase 18; EC 3.1.2.-; Usp18; ubiquitin specific peptidase 18; UBP43; Ubp15; AW047653; 1110058H21Rik|
|Gene ID :||24110|
|mRNA Refseq :||NM_011909|
|Protein Refseq :||NP_036039|
|UniProt ID :||Q9WTV6|
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