| Official Full Name | ubiquitin specific peptidase 4 (proto-oncogene) |
| Background | Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD, and JAMM enzymes. USP4 was originally identified |
| Synonyms | USP4; ubiquitin specific peptidase 4 (proto-oncogene); ubiquitin specific protease 4 (proto oncogene) , UNP; ubiquitin carboxyl-terminal hydrolase 4; Unph; ubiquitin thioesterase 4; deubiquitinating enzyme 4; ubiquitin thiolesterase 4; ubiquitous nuclear |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
USP4 involved in several pathways and played different roles in them. We selected most pathways USP4 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Death Receptor Signalling | TAX1BP1B; GNB2L1; CLIP3; USP2; FAM105B; OTULIN; OTUD7B; SHARPIN; RNF31; TAX1BP1 |
| Regulation of TNFR1 signaling | SHARPIN; TAX1BP1; FAM105B; USP2; TAX1BP1B; USP4; OTULINB; OTULIN; CLIP3; OTUD7B |
| Signal Transduction | CBY1; PDK2B; RGS7; NMBA; NET1; NOXO1A; SKIB; NOTUM1A; CLIP3; ARAP2 |
| TNF signaling | RNF31; CLIP3; OTULINB; RBCK1; SHARPIN; SHRPRBCK1R; USP4; TAX1BP1B; FAM105B; OTULIN |
| TNFR1-induced NFkappaB signaling pathway | SHRPRBCK1R; OTUD7B; SHARPIN; RNF31; USP4; USP2 |
| TNFR1-induced proapoptotic signaling | USP2; OTUD7B; USP4 |
USP4 has several biochemical functions, for example, adenosine receptor binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP4 itself. We selected most functions USP4 had, and list some proteins which have the same functions with USP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenosine receptor binding | USP4; CECR1; CECR1A |
| cysteine-type endopeptidase activity | CASP14; CASP6; CASPB; CASPC; USP4; TINAG; USP50; USP24; CASP8; USP1 |
| identical protein binding | MCM6; CNTN2; STIM1; RAD52; VWA2; CEP57L1; SDK2; GAPDH; CALHM1; GDF5 |
| metal ion binding | TET3; ZNF668; FAHD2B; PFKL; NUDT1; OVCH2; TGM1; CMC1; HDHD1A; ZFP524 |
| protein binding | HAX1; RNF13; AVPR2; SULT4A1; ZNF695; CSRP2; ETV6; C11orf54; NDE1; SCRT1 |
| ubiquitin-specific protease activity | USP40; USP3; ZRANB1B; OTUB2; TNFAIP3; USP12; USP8; USP9; ZRANB1; USP20 |
USP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP4.
ADORA2A; RIPK1; USP8; USP39; PRPF4; PRPF3; PPIH; EIF4E2; USP1; LSM8; ADSL
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