• Official Full Name
  • ubiquitin specific peptidase 46
  • Background
  • Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated;action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine;proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).
  • Synonyms
  • USP46; ubiquitin specific peptidase 46; ubiquitin specific protease 46; ubiquitin carboxyl-terminal hydrolase 46; FLJ12552; Deubiquitinating enzyme 46; FLJ11850; FLJ14283; FLJ39393; Ubiquitin carboxyl terminal hydrolase 46; Ubiquitin specific processing protease 46; Ubiquitin thioesterase 46; Ubiquitin thiolesterase 46; Ubiquitin-specific-processing protease 46; UBP46_HUMAN
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP46, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP46 Protein, GST-His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ubiquitin specific peptidase 46, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP46, His-tagged
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human USP46, SUMO tagged
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human USP46, None tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse USP46 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey USP46 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish USP46
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human USP46 cell lysate

Protein Function

USP46 has several biochemical functions, for example, protein binding, ubiquitin-specific protease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP46 itself. We selected most functions USP46 had, and list some proteins which have the same functions with USP46. You can find most of the proteins on our site.
Related Protein
Function protein binding
Related Protein ARID1A; RABAC1; NLRX1; TCEB1; FZD7; TFF1; POLD2; KIF22; MC3R; VAV2
Function ubiquitin-specific protease activity
Related Protein USP25; COPS5; CYLD; OTUD6A; OTUB1B; USP38; USP46; USP2A; ZRANB1; VCPIP1

Interacting Protein

USP46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP46 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP46.
PJA2; PHLPP1; USP12; MYL6B; IQGAP1; ALDH9A1; SET; YWHAH; DMWD; PHLPP2; WDR48; WDR20; RAD51AP1; PPP1R9B; ERP44; q9p1s2_human; EIF2AK4

USP46 Related Articles

Feng, AP; He, YM; et al. Expression of USP15, T beta R-I and Smad7 in psoriasis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 34:415-419(2014).
Imai, S; Kano, M; et al. Behavioral Characteristics of Ubiquitin-Specific Peptidase 46-Deficient Mice. PLOS ONE 8:-(2013).