usp9x
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  • Official Full Name
  • ubiquitin specific peptidase 9, X-linked
  • Background
  • This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • USP9X; ubiquitin specific peptidase 9, X-linked; FAF; FAM; DFFRX; probable ubiquitin carboxyl-terminal hydrolase FAF-X; hFAM; fat facets in mammals; ubiquitin thioesterase FAF-X; deubiquitinating enzyme FAF-X; ubiquitin thiolesterase FAF-X; fat facets protein related, X-linked; fat facets protein-related, X-linked; Drosophila fat facets related, X-linked; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific processing protease FAF-X; ubiquitin-specific-processing protease FAF-X; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila);
Cat.#:USP9X-184HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP9X, GST-tagged
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Cat.#:USP9X-658HTag:Met/His
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human USP9X, Met&His-tagged
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Cat.#:USP9X-17945MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse USP9X Protein
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Involved Pathway

USP9X involved in several pathways and played different roles in them. We selected most pathways USP9X participated on our site, such as Downregulation of SMAD2/3:SMAD4 transcriptional activity, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP9X were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Downregulation of SMAD2/3:SMAD4 transcriptional activity
USP9; SKILB; USP9X; SKI; SKIB; SMAD3B; RNF111; TRIM33; SKIA; PARP1
Gene Expression
MED8; HNRNPD; MANEA; HNRNPR; PEAK1; SAP30L; KARS; WDR4; ZNF184; HELZ2
Generic Transcription Pathway
NR1D2; ZNF740; ZNF75A; NR2F1A; ZNF529; ZNF839; ESRRGA; ZNF213; HELZ2; ZNF543
Signal Transduction
RGS7; SST1.1; PYY; PMCH; SKI; ARHGAP12B; SPRY1; ADM; CSN2; TAGAPA
Signaling by TGF-beta Receptor Complex
USP15; CGNB; NEDD8L; USP9; SKIB; UCHL5; SKILB; PMEPA1; NEDD8; USP9X
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
TRIM33; SKIB; USP9; USP9X; SKILB

Protein Function

USP9X has several biochemical functions, for example, co-SMAD binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP9X itself. We selected most functions USP9X had, and list some proteins which have the same functions with USP9X. You can find most of the proteins on our site.
Function
Related Protein
Function co-SMAD binding
Related Protein SMAD2; SMAD1; SMAD3; USP9X; CITED1; FOXH1; TGIF1; SMAD6; TRIM33; GATA4
Function cysteine-type endopeptidase activity
Related Protein CASPBL; CTSS; FAM49BA; CTSJ; CTLA2B; CTSK; CTSB; BLMH; ATG4C; USP12
Function cysteine-type peptidase activity
Related Protein CASP3B; USP9; OTUD7A; USP27X; CASP6L2; USPL1; CAPN2; FAM105B; DESI1; CTSL1B
Function protein binding
Related Protein CLOCKB; CDC5L; KEAP1; STOM; BIRC7; SYT11; FRK; LIG3; MAP3K11; SLC30A8
Function ubiquitin-specific protease activity
Related Protein USP46; USP34; ZRANB1; USP13; USP8; USP49; OTUB1A; BRCC3; UCHL1; USP51

Interacting Protein

USP9X has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP9X here. Most of them are supplied by our site. Hope this information will be useful for your research of USP9X.
NFKB2; NUAK1; MYC; JUN; PHB; CASP4; NFKB2; RELB; MAP3K1; SMAD4; TSC22D1; NEK6; HTT