|Background||Among ubiquitin-conjugating enzymes, the mammalian ubiquitin conjugating enzyme UbcH1, also known as HIP2, is unique in its ability to catalyze the in vitro synthesis of unanchored Lys48-linked poly-ubiquitin chains from mono- or poly-ubiquitin, E1, and ATP. In addition, UbcH1 can catalyse the cyclization of longer poly-ubiquitin chains, including tetra- and penta-ubiquitin. Recombinant UbcH1 charges and supports ubiquitinylation in vitro. Typical enzyme concentration to support conjugation in vitro is 100nM to 1μM. Recently, HIP2 (or UbcH1) has been shown to bind to the N terminus of Huntington and may play a role in Huntington disease.|
|Synonyms||Ubiquitin-conjugating enzyme E2-25 kDa;EC 220.127.116.11;Ubiquitin-protein ligase;Ubiquitin carrier protein;E2(25K);Huntingtin-interacting protein 2;HIP-2;HIP2;LIG;HYPG;UBE2K;UbcH1;DKFZp564C1216;DKFZp686J24237;E2-25K;huntingtin interacting protein 2;ubiquitin-conjugating enzyme E2-25K;ubiquitin-conjugating enzyme E2K (UBC1 homolog;yeast);ubiquitin-conjugating enzyme E2-25 KDA;ubiquitin-activating enzyme;ubiquitin:protein-lysine N-ligase (AMP-forming)|
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UbcH1 involved in several pathways and played different roles in them. We selected most pathways UbcH1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UbcH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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UbcH1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by UbcH1 itself. We selected most functions UbcH1 had, and list some proteins which have the same functions with UbcH1. You can find most of the proteins on our site.
UbcH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UbcH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UbcH1.