VAV3 Protein, vav 3 guanine nucleotide exchange factor


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Official Full Name vav 3 guanine nucleotide exchange factor
Background The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response.
Synonyms VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; guanine nucleotide exchange factor VAV3; VAV-3; FLJ40431
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human VAV3-119H Recombinant Human VAV3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human VAV3-1385H Recombinant Human VAV3 protein, His-tagged E.coli His
    Mouse VAV3-17991M Recombinant Mouse VAV3 Protein Mammalian Cell His
    Chicken VAV3-7087C Recombinant Chicken VAV3 Mammalian Cell His

    VAV3 involved in several pathways and played different roles in them. We selected most pathways VAV3 participated on our site, such as cAMP signaling pathway, Chemokine signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway PLN; HTR1B; SOX9; RAP1B; MAP2K1; CREB3L3; VIPR2; ATP1A3; PIK3R1; AKT1
    Chemokine signaling pathway CCL5; CCL20; GNAI3; CXCR6; CCL4L2; MAP2K1; SHC3; Ccl12; GM13306; CCR5
    Focal adhesion RAC3; ACTN2B; PDGFC; VASP; PAK2; PDPK1; SHC4; PDPK1B; Itga10&Itgb1; FLNA
    Natural killer cell mediated cytotoxicity PIK3R1; RAF1; MAPK1; MAPK3; ZAP70; PRKCG; HLA-G; KIR3DL2; PPP3R2; IFNGR1
    T cell receptor signaling pathway MAPK3; CBL; NFATC3; OXSR1A; PPP3R1; MAP3K7; MAPK12; LCP2; PTPN6; DEF6A
    B cell receptor signaling pathway NRAS; ARPC5; AKT2; PDK2B; ARPC4; BLK; AKT1; MAPK1; PIK3CA; SOS1
    Fc epsilon RI signaling pathway MAPK10; MAPK11; MAPK8; VAV2; MAPK13; PIK3R1; VAV1; FYN; AKT2; IL13
    Fc gamma R-mediated phagocytosis ARF6; GAB2; WAS; GSN; ASAP1; PAK1; MAPK1; RAC2; RAF1; AKT2
    Leukocyte transendothelial migration CLDN7; VASP; PIK3R3; PRKCB; RASSF5; CYBA; ITGA4; PTK2B; CLDN17; RHOA
    Regulation of actin cytoskeleton BRAF; PIP5K1B; GNG12A; ACTG1; EZRB; SCINLB; ITGA3B; MYL10; PAK3; PIK3CG

    VAV3 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV3 itself. We selected most functions VAV3 had, and list some proteins which have the same functions with VAV3. You can find most of the proteins on our site.

    Function Related Protein
    Rac guanyl-nucleotide exchange factor activity SPATA13; VAV3; ALS2; FARP2; VAV1; DOCK2; ARHGEF2; PREX2; ARHGEF4; FARP1
    Rho guanyl-nucleotide exchange factor activity DOCK10; FGD4; ARHGEF28; ARHGEF3; ARHGEF10; OBSCN; ARHGEF17; ARHGEF10L; PLEKHG4; ARHGEF9B
    epidermal growth factor receptor binding HBEGFA; PLSCR1; RNF126; HBEGF; FER; ATXN2; Fert2; SNX1; MS4A1; EGF
    guanyl-nucleotide exchange factor activity FGD4; RASGRF2B; GDPGP1; ARFGEF2; ARHGEF37; KALRN; RAPGEFL1; ARHGEF17; ARHGEF19; FGD2
    metal ion binding CYB5A; C22orf28; ATP1A3B; UBA2; KDM6B; ZFP322A; ZNF498; ACSM2B; CD209B; ZNF789
    protein binding PSMC6; SPATA2; MAGEB4; MED29; BCL2L16; FECH; NEUROG1; BBS9; MAP4; F2RL1

    VAV3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV3 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV3.

    Kwak, SH; Park, YJ; et al. A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans. HUMAN MOLECULAR GENETICS 23:4433-4442(2014).
    Qi, HY; Wei, L; et al. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. INTERNATIONAL JOURNAL OF ONCOLOGY 36:725-735(2010).

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