|Official Full Name||vav 3 guanine nucleotide exchange factor|
|Background||The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response.|
|Synonyms||VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; guanine nucleotide exchange factor VAV3; VAV-3; FLJ40431|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
VAV3 involved in several pathways and played different roles in them. We selected most pathways VAV3 participated on our site, such as cAMP signaling pathway, Chemokine signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|cAMP signaling pathway||PLN; HTR1B; SOX9; RAP1B; MAP2K1; CREB3L3; VIPR2; ATP1A3; PIK3R1; AKT1|
|Chemokine signaling pathway||CCL5; CCL20; GNAI3; CXCR6; CCL4L2; MAP2K1; SHC3; Ccl12; GM13306; CCR5|
|Focal adhesion||RAC3; ACTN2B; PDGFC; VASP; PAK2; PDPK1; SHC4; PDPK1B; Itga10&Itgb1; FLNA|
|Natural killer cell mediated cytotoxicity||PIK3R1; RAF1; MAPK1; MAPK3; ZAP70; PRKCG; HLA-G; KIR3DL2; PPP3R2; IFNGR1|
|T cell receptor signaling pathway||MAPK3; CBL; NFATC3; OXSR1A; PPP3R1; MAP3K7; MAPK12; LCP2; PTPN6; DEF6A|
|B cell receptor signaling pathway||NRAS; ARPC5; AKT2; PDK2B; ARPC4; BLK; AKT1; MAPK1; PIK3CA; SOS1|
|Fc epsilon RI signaling pathway||MAPK10; MAPK11; MAPK8; VAV2; MAPK13; PIK3R1; VAV1; FYN; AKT2; IL13|
|Fc gamma R-mediated phagocytosis||ARF6; GAB2; WAS; GSN; ASAP1; PAK1; MAPK1; RAC2; RAF1; AKT2|
|Leukocyte transendothelial migration||CLDN7; VASP; PIK3R3; PRKCB; RASSF5; CYBA; ITGA4; PTK2B; CLDN17; RHOA|
|Regulation of actin cytoskeleton||BRAF; PIP5K1B; GNG12A; ACTG1; EZRB; SCINLB; ITGA3B; MYL10; PAK3; PIK3CG|
VAV3 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV3 itself. We selected most functions VAV3 had, and list some proteins which have the same functions with VAV3. You can find most of the proteins on our site.
|Rac guanyl-nucleotide exchange factor activity||SPATA13; VAV3; ALS2; FARP2; VAV1; DOCK2; ARHGEF2; PREX2; ARHGEF4; FARP1|
|Rho guanyl-nucleotide exchange factor activity||DOCK10; FGD4; ARHGEF28; ARHGEF3; ARHGEF10; OBSCN; ARHGEF17; ARHGEF10L; PLEKHG4; ARHGEF9B|
|epidermal growth factor receptor binding||HBEGFA; PLSCR1; RNF126; HBEGF; FER; ATXN2; Fert2; SNX1; MS4A1; EGF|
|guanyl-nucleotide exchange factor activity||FGD4; RASGRF2B; GDPGP1; ARFGEF2; ARHGEF37; KALRN; RAPGEFL1; ARHGEF17; ARHGEF19; FGD2|
|metal ion binding||CYB5A; C22orf28; ATP1A3B; UBA2; KDM6B; ZFP322A; ZNF498; ACSM2B; CD209B; ZNF789|
|protein binding||PSMC6; SPATA2; MAGEB4; MED29; BCL2L16; FECH; NEUROG1; BBS9; MAP4; F2RL1|
VAV3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV3 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV3.