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VAV3

Official Full Name

vav 3 guanine nucleotide exchange factor
Overview

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response.
Synonyms

VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; guanine nucleotide exchange factor VAV3; VAV-3; FLJ40431;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	VAV3-1385H	Recombinant Human VAV3 protein, His-tagged	E.coli	His	His183~Glu380 (Accession # Q9UKW4)	Inquiry
Human	VAV3-6117H	Recombinant Human VAV3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	VAV3-2335H-B	Recombinant Human VAV3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	VAV3-119H	Recombinant Human VAV3 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	VAV3-1968H	Recombinant Human VAV3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	VAV3-2335H	Recombinant Human VAV3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	VAV3-1909HFL	Recombinant Full Length Human VAV3 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Mouse	VAV3-17991M	Recombinant Mouse VAV3 Protein	Mammalian Cell	His		Inquiry
Mouse	VAV3-10002M	Recombinant Mouse VAV3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Vav3-6906M	Recombinant Mouse Vav3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	VAV3-10002M-B	Recombinant Mouse VAV3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	VAV3-7087C	Recombinant Chicken VAV3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
VAV3 Related Articles
VAV3 Related Signal Pathway

VAV3 involved in several pathways and played different roles in them. We selected most pathways VAV3 participated on our site, such as cAMP signaling pathway, Chemokine signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cAMP signaling pathway	RRAS2;PDE3B;CAMK2B;ATP1B2;PPP1R12A;GRIA2;HCN4;HHIP;LOC100328615
Chemokine signaling pathway	PF4;SHC2;PLCB3;IKBKB;IL-8;CXCL9;CCR5;LOC100033925;GSK3B
Focal adhesion	PGF;ACTB2;MYLPF;COL27A1B;ITGB6;PAK7;COL4A2;FN1A;VEGFB
Natural killer cell mediated cytotoxicity	IFNA12;HLA-A;KLRA8;IFNA1;HLA-B;IFNA8;NCR3;PLCG1;HLA-E
T cell receptor signaling pathway	VAV3;LCK;NFKBIB;IKBKG;CARD11;PIK3CD;PAK3;MAPK12;CD4
B cell receptor signaling pathway	cgr2b;CD79B;PIK3R1;RELA;VAV1;DOK1B;IKBKG;MAPK3;RASGRP3
Fc epsilon RI signaling pathway	MAPK12;AKT1;HRAS;FCER1G;RAF1;LYN;FCER1A;PIK3R3;GRB2
Fc gamma R-mediated phagocytosis	PLA2G4D;CFL2;RAF1;PIK3R5;MAP2K1;RAC1;PLA2G4A;NCF1;AKT2
Leukocyte transendothelial migration	PIK3R2;MMP2;CYBB;MYL2;EZR;JAM3;ESAM;ITGAL;ACTN2
Regulation of actin cytoskeleton	ARHGEF1;INS2;ARPC5L;ENAH;ACTN3A;CYFIP1;MYL5;DIAPH3;TMSB

VAV3 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV3 itself. We selected most functions VAV3 had, and list some proteins which have the same functions with VAV3. You can find most of the proteins on our site.

Function	Related Protein
Rac guanyl-nucleotide exchange factor activity	VAV3;FARP2;DOCK2;SPATA13;ARHGEF2;PREX2;VAV1;ARHGEF4;ALS2
Rho guanyl-nucleotide exchange factor activity	PLEKHG5;DOCK10;ARHGEF39;FLJ20184;C9orf100;ARHGEF37;PLEKHG3;ARHGEF7;ARHGEF10
epidermal growth factor receptor binding	TNK2;LINGO1B;CBLC;EFEMP1;ATXN2;SHC1;RNF126;YES1;PLSCR1
guanyl-nucleotide exchange factor activity	TRIOA;DOCK4B;SH2D3C;GAPVD1;ARHGEF3L;RALGPS1;PCP2;DOCK11;DOCK5
metal ion binding	TGM5;CDK5RAP1;NUDT1;PM20D1.2;TIMM8B;ANKMY2;SCD5;HBBE2;ZNF688
protein binding	PSMB9;ARL4C;COA3;IKZF3;EIF3A;CASP7;KRIT1;IRS4;KTN1

VAV3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV3 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV3.

Kwak, SH; Park, YJ; et al. A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans. HUMAN MOLECULAR GENETICS 23:4433-4442(2014).

Qi, HY; Wei, L; et al. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. INTERNATIONAL JOURNAL OF ONCOLOGY 36:725-735(2010).