vdac1
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  • Official Full Name
  • voltage-dependent anion channel 1
  • Background
  • This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
  • Synonyms
  • VDAC1; voltage-dependent anion channel 1; PORIN; VDAC-1; voltage-dependent anion-selective channel protein 1; porin 31HL; porin 31HM; plasmalemmal porin; outer mitochondrial membrane protein porin 1;
Cat.#:VDAC1-595HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VDAC1 Protein, His/GST-tagged
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Cat.#:VDAC1-16HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Voltage-Dependent Anion Channel-1
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Cat.#:VDAC1-17HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human VDAC1, GST-tagged
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Cat.#:VDAC1-18HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VDAC1, GST-tagged
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Cat.#:VDAC1-19HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VDAC1, His-tagged
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Cat.#:VDAC1-21HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant human full length VDAC1, GST-tagged
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Cat.#:VDAC1-18000MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse VDAC1 Protein
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Cat.#:VDAC1-6510RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat VDAC1 Protein
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Cat.#:VDAC1-5150RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey VDAC1 Protein, His-tagged
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Cat.#:VDAC1-3268CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken VDAC1
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Cat.#:VDAC1-209ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish VDAC1
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Cat.#:VDAC1-732HCLTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human VDAC1 lysate, Flag-tagged
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Involved Pathway

VDAC1 involved in several pathways and played different roles in them. We selected most pathways VDAC1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
CHRM2; SLC8A1A; HTR5A; PHKG1A; PLCB1; GRIN1B; PHKB; ADRB2; CAMK2G1; P2RX3
cGMP-PKG signaling pathway
MEF2B; PPP3R1; ITPR3; PPP1CB; PIK3CD; GTF2IRD1; VDAC2; NPPB; NFATC4; GNAI2
Parkinsons disease
NDUFS7; NDUFA4; PARK7; ATP5E; NDUFS3; mt-Atp8; ATP5D; MT-ND1; NDUFB1; NDUFA8
Huntingtons disease
DNALC4; VDAC1; NDUFA6; ATP5A1; COX6A2; SLC25A31; mt-Atp8; SDHA; GNAQ; SIN3A
Influenza A
BLB1; IFNB; IRF9; IL-8; MAP2K1; EIF2AK2; HLA-DQA1; IFNA12; NFKBIA; MAP2K4
HTLV-I infection
EGR1; PPP3CB; SLC25A5; FOSL1; ANAPC7; FZD7; AKT2; WNT10B; GM-CSF; CCND2

Protein Function

VDAC1 has several biochemical functions, for example, ion channel binding, porin activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC1 itself. We selected most functions VDAC1 had, and list some proteins which have the same functions with VDAC1. You can find most of the proteins on our site.
Function
Related Protein
Function ion channel binding
Related Protein NOS1; AASS; HOMER1; FKBP1A; ACTN3; ABCC9; KCNB1; CTNNB1; SNTA1; GRINA
Function porin activity
Related Protein VDAC2; VDAC1; TOMM40; VDAC3; AQP9; TOMM40L
Function protein binding
Related Protein SLC39A13; CD70; THAP7; TMEM173; FAM115A; RAET1D; RAB3IP; ESRP1; SYNE1; L3MBTL1
Function protein complex binding
Related Protein PLK2; OTOF; EPHB1; TRADD; GIT2; NDUFA8; KAT6B; RAP1A; ITPR1; SLC27A5
Function protein kinase binding
Related Protein CASP9; FBXW5; TICAM1; CDK5RAP1; PPP1CC; CD8A; IRS2; AP2A2; XBP1; PEBP1
Function voltage-gated anion channel activity
Related Protein VDAC2; GPR89; VDAC1; VDAC3; SLC17A3

Interacting Protein

VDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC1.
ATF2; Bax; BAK1; VCAM1; env; HSPA9; ITPR1; cholesterol; nadh

VDAC1 Related Articles

Li, L; Yao, YC; et al. Plasminogen Kringle 5 Induces Endothelial Cell Apoptosis by Triggering a Voltage-dependent Anion Channel 1 (VDAC1) Positive Feedback Loop. JOURNAL OF BIOLOGICAL CHEMISTRY 289:-(2014).
Nikiforova, AB; Saris, NEL; et al. External mitochondrial NADH-dependent reductase of redox cyclers: VDAC1 or Cyb5R3?. FREE RADICAL BIOLOGY AND MEDICINE 74:74-84(2014).