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VDAC3

  • Official Full Name

    voltage-dependent anion channel 3

  • Overview

    This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are;small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small;metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in;translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition;pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript;variants encoding different isoforms have been described for this gene.
  • Synonyms

    VDAC3; voltage-dependent anion channel 3; voltage-dependent anion-selective channel protein 3; hVDAC3; mVDAC3; Outer mitochondrial membrane protein porin 3; voltage dependent anion channel 3; VDAC-3; voltage-dependent anion channel 5, pseudogene; voltage-dependent anion channel 1 pseudogene 5; VDAC5P; VDAC1P5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VDAC3-965H Recombinant Human VDAC3 Mammalian Cell His
Human VDAC3-155H Recombinant Human VDAC3 Protein, GST/His-tagged E.coli GST/His
Human VDAC3-417HCL Recombinant Human VDAC3 293 Cell Lysate HEK293 N/A
Human VDAC3-4286H Recombinant Human VDAC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human VDAC3-3182H Recombinant Human VDAC3 protein, His-tagged E.coli His 1-283 aa
Human VDAC3-4286H-B Recombinant Human VDAC3 Protein Pre-coupled Magnetic Beads HEK293
Rat VDAC3-6512R Recombinant Rat VDAC3 Protein Mammalian Cell His
Rat VDAC3-6168R Recombinant Rat VDAC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat VDAC3-6168R-B Recombinant Rat VDAC3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish VDAC3-12447Z Recombinant Zebrafish VDAC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • VDAC3 Related Articles

VDAC3 involved in several pathways and played different roles in them. We selected most pathways VDAC3 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayATP2A3;PRKACBB;P2RX8;GNA15.4;CALM2;TNNC1;PRKCG;GRM1;CHRNA7
cGMP-PKG signaling pathwayVDAC3;ATP1A2;PDE5A;NPPB;KCNJ8;GUCY1A3;MYH7;PIK3CD;ATP2B4
Parkinsons diseaseCOX7B;ATP5D;PINK1;ATP5J;UQCRQ;ATP5F1;NDUFB11;ATP5A1;PARK2
Huntingtons diseaseSDHD;COX7C;COX6B2;NDUFS4;HIP1;NDUFC2;DCTN1;SLC25A5;NDUFA10
Hepatitis BSTAT5B;VDAC3;IKBKE;CREB3L3;CREB3L2;OSTN;FOS;RELA;PRKCG
HTLV-I infectionPRKACB;TNFRSF13C;GM-CSF;MYBL1;HLA-E;HLA-DRA;TRP53INP1;PDGFA;DVL1
Viral carcinogenesisYWHAH;TP53;MAD1L1;HIST1H4E;CDC20;HIST1H2BD;PMAIP1;KAT2A;ATF4

VDAC3 has several biochemical functions, for example, nucleotide binding, porin activity, voltage-gated anion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC3 itself. We selected most functions VDAC3 had, and list some proteins which have the same functions with VDAC3. You can find most of the proteins on our site.

Function Related Protein
nucleotide bindingHSP104;RHOBTB2A;EGFRA;RAVER1;CNOT4B;MOV10B.2;HIPK2;RPS6KB1B;PRKCDA
porin activityTOMM40;TOMM40L;VDAC2;VDAC1;AQP9;VDAC3
voltage-gated anion channel activityVDAC3;VDAC1;VDAC2;GPR89;SLC17A3

VDAC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC3.

env; HLA-B; MAGEA6; CASP4; ACTB; Tubb4b; DHRS2; SERINC3; IKBKE; GSTK1; DDX24; ATF2; HTT; ICT1; Rmdn3; SLC38A1; ACAD9

Messina, A; Reina, S; et al. Live cell interactome of the human voltage dependent anion channel 3 (VDAC3) revealed in HeLa cells by affinity purification tag technique. MOLECULAR BIOSYSTEMS 10:2134-2145(2014).
Narendra, DP; Kane, LA; et al. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. AUTOPHAGY 6:1090-1106(2010).
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