|Official Full Name||vacuolar protein sorting 18 homolog (S. cerevisiae)|
|Background||Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.|
|Synonyms||VPS18; vacuolar protein sorting 18 homolog (S. cerevisiae); vacuolar protein sorting protein 18; vacuolar protein sorting-associated protein 18 homolog; KIAA1475; PEP3; hVPS18; Vacuolar protein sorting 18; OTTHUMP00000160630|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
VPS18 involved in several pathways and played different roles in them. We selected most pathways VPS18 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
VPS18 has several biochemical functions, for example, actin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS18 itself. We selected most functions VPS18 had, and list some proteins which have the same functions with VPS18. You can find most of the proteins on our site.
|actin binding||ANG; ABLIM1A; GSNA; CALD1; SPTBN2; LCP1; CNN3; GMFB; EZRA; SYNE1|
|metal ion binding||BRCC3; GMPR; ETFDH; ZFP326; ZNF707; ATF2; ITGA8; ZNF37A; DOHH; GTF3AA|
|protein binding||PTPN13; RFX4; CRHBP; SCHIP1; WDR77; CYLD; PLEKHB2; PSMD14; DEFA6; SLIT2|
|protein binding, bridging||TRIM5; SYNM; TRIM17; PPP4R2; WWC1; CAV2; ANXA1; CUX1; ST13; FSCN2|
|syntaxin binding||CPLX2L; PLDN; SNAP23.1; TXLNBB; SYT17; CPLX4C; RPH3AL; SYT5; STX6; STXBP5L|
VPS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS18.