vps45
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  • Official Full Name
  • vacuolar protein sorting 45 homolog (S. cerevisiae)
  • Background
  • Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.
  • Synonyms
  • VPS45; vacuolar protein sorting 45 homolog (S. cerevisiae); vacuolar protein sorting 45A (yeast homolog) , vacuolar protein sorting 45A (yeast) , VPS45A, VPS45B; vacuolar protein sorting-associated protein 45; h vps45; H1; h-VPS45; H1VPS45; HGNC:14579; hlVps45; Leucocyte vacuolar protein sorting 45; OTTHUMP00000014482; Vacuolar protein sorting 45A (yeast homolog); Vacuolar protein sorting 45A; Vacuolar protein sorting 45B (yeast); VPS45_HUMAN; VPS45A; VPS45B; VPS54A; VSP45; VSP45A
Cat.#:VPS45-18379MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse VPS45 Protein
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Cat.#:VPS45-6544RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat VPS45 Protein
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Cat.#:VPS45-3233CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken VPS45
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Cat.#:VPS45-8184ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish VPS45
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Cat.#:VPS45-384HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human VPS45 293 Cell Lysate
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Involved Pathway

VPS45 involved in several pathways and played different roles in them. We selected most pathways VPS45 participated on our site, such as Endocytosis, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS45 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
PRKCZ; RNF41; EPN1; PIP5K1AA; CYTH4B; ERBB4; RHOAB; CXCR2; IL2RA; FOLR2
Factors involved in megakaryocyte development and platelet production
KIF4; BA2; GATA2A; ITPK1; HBBE3; MAFGA; KIF4A; KIF5A; ZFPM1; DOCK1
Hemostasis
RACGAP1; APOER2; ZFPM1; KIF9; GATA2A; CLU; F9A; DOCK2; CFD; SIRPA

Protein Function

VPS45 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS45 itself. We selected most functions VPS45 had, and list some proteins which have the same functions with VPS45. You can find most of the proteins on our site.
Function
Related Protein
Function molecular_function
Related Protein MFHAS1; UCMAB; IFI27L2A; DCAF12; TNKS1BP1; FAM115E; CRP4; KHNYN; PRL5A1; MFSD6B
Function protein binding
Related Protein COPS3; PEX26; Fert2; DAZAP2; IRF3; PICALM; DYM; NUP205; C6orf226; ATRIP

Interacting Protein

VPS45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS45 here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS45.
RBSN; BCAR3; IGF1R; PTPN1; PAX2; CASP8; RB1CC1; gtp; pi3p; ere_dna