wdr35
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  • Official Full Name
  • WD repeat domain 35
  • Background
  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.
  • Synonyms
  • WDR35; WD repeat domain 35; WD repeat-containing protein 35; KIAA1336; MGC33196; naofen; intraflagellar transport protein 121 homolog; CED2
Cat.#:WDR35-18467MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WDR35 Protein
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Cat.#:WDR35-7338ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WDR35
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Involved Pathway

WDR35 involved in several pathways and played different roles in them. We selected most pathways WDR35 participated on our site, such as Assembly of the primary cilium, Hedgehog off state, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR35 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
HDAC6; CCT3; KIF3C; TTC26; IQCB1; IFT20; CSNK1D; TRIP11; RPGRIP1L; ARF4
Hedgehog off state
IFT172; MKS1; KIF7; GPR161; BBS13; IFT88; IFT122; IFT52; RPGRIP1L; OFD1
Intraflagellar transport
TNPO1; TTC30A; KIF3C; IFT122; DYNLL2B; TCTEX1D1; KIFAP3; IFT22; DYNLL2; IFT81
Organelle biogenesis and maintenance
MRPL53; NPHP3; CNGA2; ARF4; MKKS; MRPS23; AURKAIP1; MRRF; MRPS36; CCDC123
Signal Transduction
KDM4C; RNF146; CSHL1; ARHGAP25; C; ARHGEF1A; LIN7B; CXCL11.8; BCO2; ALDH8A1
Signaling by Hedgehog
EVC; CDC73; DISP2; SCUBE2; IQCE; GPR161; IFT122; BOC; NOTUM1A; TULP3

Protein Function

WDR35 has several biochemical functions, for example, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR35 itself. We selected most functions WDR35 had, and list some proteins which have the same functions with WDR35. You can find most of the proteins on our site.
Function
Related Protein
Function phosphatidylinositol binding
Related Protein SNX6; RPS6KC1; CCDC88A; NCF1; ITPR3; RAG2; SNX7; SNX33; SNX18A; SNX32