This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).
WDR36 involved in several pathways and played different roles in them. We selected most pathways WDR36 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
WDR36 has several biochemical functions, for example, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR36 itself. We selected most functions WDR36 had, and list some proteins which have the same functions with WDR36. You can find most of the proteins on our site.
Function poly(A) RNA binding
Related Protein SLTM; NHP2; HNRNPA2B1; ABCF1; SUB1; SECISBP2; RPL31; DDX31; DDX51; RPS13
WDR36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR36 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR36.
Takamoto, M; Araie, M; et al. Genetics of primary open angle glaucoma. JAPANESE JOURNAL OF OPHTHALMOLOGY 58:1-15(2014).
Li, XN; Ampleford, EJ; et al. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 130:861-+(2012).