WFDC5 Protein, WAP four-disulfide core domain 5


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Official Full Name WAP four-disulfide core domain 5
Background This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.
Synonyms WFDC5; WAP four-disulfide core domain 5; WAP four-disulfide core domain protein 5; dJ211D12.5; WAP1; p53 responsive gene 5; p53 responsive gene 5 protein; p53-responsive gene 5; p53-responsive gene 5 protein; PRG5; Protease inhibitor WAP1; Putative protease inhibitor WAP1; WAP four disulfide core domain 5
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WFDC5-319HCL Recombinant Human WFDC5 293 Cell Lysate HEK293 N/A
    Human WFDC5-3728H Recombinant Human WFDC5, GST-tagged E.coli GST
    Mouse Wfdc5-1224M Recombinant Mouse Wfdc5 protein, His & GST-tagged E.coli His/GST
    Rat Wfdc5-1225R Recombinant Rat Wfdc5 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque WFDC5-5214R Recombinant Rhesus monkey WFDC5 Protein, His-tagged Mammalian Cell His

    WFDC5 involved in several pathways and played different roles in them. We selected most pathways WFDC5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WFDC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    WFDC5 has several biochemical functions, for example, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WFDC5 itself. We selected most functions WFDC5 had, and list some proteins which have the same functions with WFDC5. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase inhibitor activity SERPINI2; SPINK8; TFPI; SERPINB9; SERPINB4; FURIN; WFDC8; SPINT4; WFDC6; SERPINA1E

    WFDC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WFDC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of WFDC5.

    Lindquist, JA; Mertens, PR; et al. Myofibroblasts, regeneration or renal fibrosisuis there a decisive hint?. NEPHROLOGY DIALYSIS TRANSPLANTATION 28:2678-2681(2013).
    Li, FM; Wang, LL; et al. A double WAP domain-containing protein from Chinese mitten crab Eriocheir sinensis with antimicrobial activities against Gram-negative bacteria and yeast. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 36:183-190(2012).

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